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MKCE_DICDI
ID   MKCE_DICDI              Reviewed;         715 AA.
AC   Q54TN4;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Probable serine/threonine-protein kinase mkcE {ECO:0000312|EMBL:EAL66586.1};
DE            EC=2.7.11.1;
DE   AltName: Full=MAP kinase cascade E {ECO:0000312|dictyBase:DDB_G0281649};
GN   Name=mkcE {ECO:0000312|EMBL:EAL66586.1}; ORFNames=DDB_G0281649;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1] {ECO:0000312|EMBL:EAL66586.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4 {ECO:0000312|EMBL:EAL66586.1};
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000250|UniProtKB:Q869N2};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1; Evidence={ECO:0000250|UniProtKB:Q869N2};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000250|UniProtKB:Q869N2};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. STE20 subfamily. {ECO:0000305}.
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DR   EMBL; AAFI02000042; EAL66586.1; -; Genomic_DNA.
DR   RefSeq; XP_640557.1; XM_635465.1.
DR   AlphaFoldDB; Q54TN4; -.
DR   SMR; Q54TN4; -.
DR   STRING; 44689.DDB0230009; -.
DR   PaxDb; Q54TN4; -.
DR   EnsemblProtists; EAL66586; EAL66586; DDB_G0281649.
DR   GeneID; 8623167; -.
DR   KEGG; ddi:DDB_G0281649; -.
DR   dictyBase; DDB_G0281649; mkcE.
DR   eggNOG; KOG0578; Eukaryota.
DR   HOGENOM; CLU_386588_0_0_1; -.
DR   InParanoid; Q54TN4; -.
DR   OMA; KNDEEIW; -.
DR   PRO; PR:Q54TN4; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF00069; Pkinase; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Kinase; Magnesium; Metal-binding;
KW   Nucleotide-binding; Reference proteome; Repeat;
KW   Serine/threonine-protein kinase; Transferase.
FT   CHAIN           1..715
FT                   /note="Probable serine/threonine-protein kinase mkcE"
FT                   /id="PRO_0000381743"
FT   DOMAIN          427..683
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   REGION          1..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          228..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          366..385
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          207..241
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..31
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..125
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        550
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:P28523,
FT                   ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-
FT                   ProRule:PRU10027"
FT   BINDING         433..441
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:P28523,
FT                   ECO:0000255|PROSITE-ProRule:PRU00159"
FT   BINDING         459
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250|UniProtKB:P28523,
FT                   ECO:0000255|PROSITE-ProRule:PRU00159"
SQ   SEQUENCE   715 AA;  79470 MW;  F8FA4548C2DFC9C6 CRC64;
     MQKIVSFLKK KKEPNSWSNF DRSDDKSKSL SKKGSLYANG NYDGGGSGSG SGGSSSNSSG
     SSRKINTGGN NRNGGGMVHS PSNSSISSTS SNNSNSTTAS SSSKLKGNKN RNSSGKQKNS
     SSQHQQYGNT YYLDDECDSD DFIPGEVRSI SKTIDFSKSE RKWLTSLNIP QELLDGNINV
     LLNVLNFLSK KEGILYIQTP TNIINNTGKK NFQQQQLQQL QQQQQQQQLQ QQQHQQHNHQ
     IYGNGNNNNL NVNVNVNGNN NNSNNNNGNY TSYVNSRSNS IASNNSSITP STSCSNLNND
     NNNNNNNNCT DNNSNNNNNN NNNNSTTTTT TITNTNVNMI GASNINSSKS NLNSLLLSGG
     SNGNGGVDNL SSTTTSLSQN PPIQPMRRSD YNRIFIEPGK FYIFPESESF ALARLVVEEE
     DPSKLFRIGE NAEVKGAFGT VYQVFYVNGQ YNNVDVALKK MDHKSEKKRR NNLNEISILR
     YLKHPNIVTY INSYEKNDEE IWMVMEYMDG GTIRDAISNF TFTEKYVAYI TKEILHSLEY
     LASLNIAHRD LKSSNIMINS KAEVKLIDFG FSIDLTHLKQ DINMCGSPFY MSPEQIQDKA
     HGLAVDIWSL GIVVAEMVRG RVPHHKSKIK AMFLAGTVGV KFSKEKKYSC HWSPELFDFL
     NVCLQMDPTK RPTPTQLLQH PFIATAATKA ETLDLLPLLF MSKTLSKLSR GRDNQ
 
 
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