ID   MKL_MYCLE               Reviewed;         347 AA.
AC   P30769; Q9CBK8;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 2.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Probable ribonucleotide transport ATP-binding protein mkl;
GN   Name=mkl; OrderedLocusNames=ML1892;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8446028; DOI=10.1111/j.1365-2958.1993.tb01112.x;
RA   Honore N.T., Bergh S., Chanteau S., Doucet-Populaire F., Eiglmeier K.,
RA   Garnier T., Georges C., Launois P., Limpaiboon T., Newton S., Niang K.,
RA   del Portillo P., Ramesh G.R., Reddi P., Ridel P.R., Sittisombut N.,
RA   Wu-Hunter S., Cole S.T.;
RT   "Nucleotide sequence of the first cosmid from the Mycobacterium leprae
RT   genome project: structure and function of the Rif-Str regions.";
RL   Mol. Microbiol. 7:207-214(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: Not known, could be involved in the transport of
CC       ribonucleotides.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAC30846.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; Z14314; CAA78667.1; -; Genomic_DNA.
DR   EMBL; AL583923; CAC30846.1; ALT_INIT; Genomic_DNA.
DR   PIR; F87145; F87145.
DR   PIR; S31144; S31144.
DR   AlphaFoldDB; P30769; -.
DR   SMR; P30769; -.
DR   STRING; 272631.ML1892; -.
DR   EnsemblBacteria; CAC30846; CAC30846; CAC30846.
DR   KEGG; mle:ML1892; -.
DR   Leproma; ML1892; -.
DR   eggNOG; COG1127; Bacteria.
DR   HOGENOM; CLU_000604_1_0_11; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR030296; MlaF/Mkl.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR43023:SF6; PTHR43023:SF6; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Nucleotide-binding; Reference proteome; Transport.
FT   CHAIN           1..347
FT                   /note="Probable ribonucleotide transport ATP-binding
FT                   protein mkl"
FT                   /id="PRO_0000092520"
FT   DOMAIN          16..252
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         48..55
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   CONFLICT        158..160
FT                   /note="KRA -> NVP (in Ref. 1; CAA78667)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   347 AA;  37628 MW;  3CAB8CCCCDA0EB5B CRC64;
     MAAIGGDGRM PMGVAIEVKG LTKSFGSSRI WEDVTLDIPA GEVSVLLGPS GTGKSVFLKS
     LIGLLRPERG SILIDGTDII ECSAKELYEI RTLFGVLFQD GALFGSMNLY DNTAFPLREH
     TKKKESEIRD IVMEKLQLVG LGGDEKKFPG EISGGMRKRA GLARALVLDP QIILCDEPDS
     GLDPVRTAYL SQLIMDINAQ IDATILIVTH NVNIARTVPD NMGMLFRKHL VMFGPREVLL
     TSDEPVVRQF LNGRRIGPIG MSEEKDESTM AEEAALLEAG HYAGGAEEVE GVPPQITVTP
     GMPKRKAVAR RQARVRAMLP TLPKGAQAAI LDDLEGAHNY QAHEFGD