MKX_HUMAN
ID MKX_HUMAN Reviewed; 352 AA.
AC Q8IYA7; B3KWM5;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Homeobox protein Mohawk;
GN Name=MKX; Synonyms=C10orf48, IRXL1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May act as a morphogenetic regulator of cell adhesion.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TALE/IRO homeobox family. {ECO:0000305}.
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DR EMBL; AK125339; BAG54187.1; -; mRNA.
DR EMBL; AC024606; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471072; EAW86052.1; -; Genomic_DNA.
DR EMBL; CH471072; EAW86053.1; -; Genomic_DNA.
DR EMBL; BC036207; AAH36207.1; -; mRNA.
DR CCDS; CCDS7156.1; -.
DR RefSeq; NP_001229631.1; NM_001242702.1.
DR RefSeq; NP_775847.2; NM_173576.2.
DR RefSeq; XP_016871594.1; XM_017016105.1.
DR RefSeq; XP_016871595.1; XM_017016106.1.
DR AlphaFoldDB; Q8IYA7; -.
DR SMR; Q8IYA7; -.
DR BioGRID; 129453; 16.
DR IntAct; Q8IYA7; 4.
DR STRING; 9606.ENSP00000364946; -.
DR iPTMnet; Q8IYA7; -.
DR PhosphoSitePlus; Q8IYA7; -.
DR BioMuta; MKX; -.
DR DMDM; 296437371; -.
DR MassIVE; Q8IYA7; -.
DR PaxDb; Q8IYA7; -.
DR PeptideAtlas; Q8IYA7; -.
DR PRIDE; Q8IYA7; -.
DR ProteomicsDB; 71134; -.
DR Antibodypedia; 1800; 235 antibodies from 26 providers.
DR DNASU; 283078; -.
DR Ensembl; ENST00000375790.9; ENSP00000364946.4; ENSG00000150051.14.
DR Ensembl; ENST00000419761.6; ENSP00000400896.1; ENSG00000150051.14.
DR GeneID; 283078; -.
DR KEGG; hsa:283078; -.
DR MANE-Select; ENST00000419761.6; ENSP00000400896.1; NM_173576.3; NP_775847.2.
DR UCSC; uc001itx.5; human.
DR CTD; 283078; -.
DR DisGeNET; 283078; -.
DR GeneCards; MKX; -.
DR HGNC; HGNC:23729; MKX.
DR HPA; ENSG00000150051; Tissue enhanced (ovary, prostate).
DR neXtProt; NX_Q8IYA7; -.
DR OpenTargets; ENSG00000150051; -.
DR PharmGKB; PA134964449; -.
DR VEuPathDB; HostDB:ENSG00000150051; -.
DR eggNOG; KOG0773; Eukaryota.
DR GeneTree; ENSGT00940000156227; -.
DR HOGENOM; CLU_049743_0_0_1; -.
DR InParanoid; Q8IYA7; -.
DR OMA; KCDSAAN; -.
DR OrthoDB; 631777at2759; -.
DR PhylomeDB; Q8IYA7; -.
DR TreeFam; TF319371; -.
DR PathwayCommons; Q8IYA7; -.
DR SignaLink; Q8IYA7; -.
DR SIGNOR; Q8IYA7; -.
DR BioGRID-ORCS; 283078; 8 hits in 1070 CRISPR screens.
DR ChiTaRS; MKX; human.
DR GeneWiki; MKX; -.
DR GenomeRNAi; 283078; -.
DR Pharos; Q8IYA7; Tbio.
DR PRO; PR:Q8IYA7; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q8IYA7; protein.
DR Bgee; ENSG00000150051; Expressed in calcaneal tendon and 125 other tissues.
DR ExpressionAtlas; Q8IYA7; baseline and differential.
DR Genevisible; Q8IYA7; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048468; P:cell development; IBA:GO_Central.
DR GO; GO:0007517; P:muscle organ development; ISS:HGNC-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR Pfam; PF05920; Homeobox_KN; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..352
FT /note="Homeobox protein Mohawk"
FT /id="PRO_0000268856"
FT DNA_BIND 71..132
FT /note="Homeobox; TALE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 19..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 159..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 245..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 40
FT /note="R -> H (in dbSNP:rs34439626)"
FT /id="VAR_033875"
FT CONFLICT 11
FT /note="G -> S (in Ref. 4; AAH36207)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 352 AA; 39331 MW; 6450BDEF5BCCEDE9 CRC64;
MNTIVFNKLS GAVLFEDGGA SERERGGRPY SGVLDSPHAR PEVGIPDGPP LKDNLGLRHR
RTGARQNGGK VRHKRQALQD MARPLKQWLY KHRDNPYPTK TEKILLALGS QMTLVQVSNW
FANARRRLKN TVRQPDLSWA LRIKLYNKYV QGNAERLSVS SDDSCSEDGE NPPRTHMNEG
GYNTPVHHPV IKSENSVIKA GVRPESRASE DYVAPPKYKS SLLNRYLNDS LRHVMATNTT
MMGKTRQRNH SGSFSSNEFE EELVSPSSSE TEGNFVYRTD TLENGSNKGE SAANRKGPSK
DDTYWKEINA AMALTNLAQG KDKLQGTTSC IIQKSSHIAE VKTVKVPLVQ QF
