MKX_MOUSE
ID MKX_MOUSE Reviewed; 353 AA.
AC Q8BIA3;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 25-MAY-2022, entry version 128.
DE RecName: Full=Homeobox protein Mohawk;
GN Name=Mkx;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=16408284; DOI=10.1002/dvdy.20671;
RA Anderson D.M., Arredondo J., Hahn K., Valente G., Martin J.F.,
RA Wilson-Rawls J., Rawls A.;
RT "Mohawk is a novel homeobox gene expressed in the developing mouse
RT embryo.";
RL Dev. Dyn. 235:792-801(2006).
CC -!- FUNCTION: May act as a morphogenetic regulator of cell adhesion.
CC Participates in the early events that lead to differentiation.
CC {ECO:0000269|PubMed:16408284}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Transcribed in developmentally important regions
CC that give rise to skeletal muscle, tendons, cartilage, male gonads, and
CC the ureteric buds of the kidney. Expressed in discrete premyogenic cell
CC populations of the somite, in the condensing prechondrogenic
CC mesenchymal cells of the axial skeleton, in the pretendenous cells of
CC the tail and limbs, the testis cords of the developing male gonad, and
CC in the metanephric kidney. {ECO:0000269|PubMed:16408284}.
CC -!- SIMILARITY: Belongs to the TALE/IRO homeobox family. {ECO:0000305}.
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DR EMBL; AK034675; BAC28793.1; -; mRNA.
DR RefSeq; NP_808263.2; NM_177595.4.
DR AlphaFoldDB; Q8BIA3; -.
DR SMR; Q8BIA3; -.
DR BioGRID; 229176; 2.
DR STRING; 10090.ENSMUSP00000078718; -.
DR iPTMnet; Q8BIA3; -.
DR PhosphoSitePlus; Q8BIA3; -.
DR PaxDb; Q8BIA3; -.
DR PRIDE; Q8BIA3; -.
DR ProteomicsDB; 295678; -.
DR DNASU; 210719; -.
DR GeneID; 210719; -.
DR KEGG; mmu:210719; -.
DR CTD; 283078; -.
DR MGI; MGI:2687286; Mkx.
DR eggNOG; KOG0773; Eukaryota.
DR InParanoid; Q8BIA3; -.
DR OrthoDB; 631777at2759; -.
DR PhylomeDB; Q8BIA3; -.
DR BioGRID-ORCS; 210719; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Mkx; mouse.
DR PRO; PR:Q8BIA3; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8BIA3; protein.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IC:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:MGI.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IPI:MGI.
DR GO; GO:0048468; P:cell development; IBA:GO_Central.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; ISO:MGI.
DR GO; GO:0030199; P:collagen fibril organization; IMP:MGI.
DR GO; GO:0036077; P:intratendonous ossification; ISO:MGI.
DR GO; GO:0007517; P:muscle organ development; IEP:HGNC-UCL.
DR GO; GO:0032331; P:negative regulation of chondrocyte differentiation; ISO:MGI.
DR GO; GO:0045599; P:negative regulation of fat cell differentiation; ISO:MGI.
DR GO; GO:0045662; P:negative regulation of myoblast differentiation; IDA:MGI.
DR GO; GO:0030279; P:negative regulation of ossification; ISO:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0032967; P:positive regulation of collagen biosynthetic process; IMP:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:NTNU_SB.
DR GO; GO:0010468; P:regulation of gene expression; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0035990; P:tendon cell differentiation; IMP:MGI.
DR GO; GO:0035992; P:tendon formation; IMP:MGI.
DR GO; GO:0002932; P:tendon sheath development; IMP:MGI.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR008422; Homeobox_KN_domain.
DR Pfam; PF05920; Homeobox_KN; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT CHAIN 1..353
FT /note="Homeobox protein Mohawk"
FT /id="PRO_0000268857"
FT DNA_BIND 71..132
FT /note="Homeobox; TALE-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 18..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..289
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 353 AA; 39401 MW; C0301988D7DBAFA8 CRC64;
MNTIVFNKLG GAVLFEDRGT PDRERGSRTF SGFLDNPHTG PEVGIPDGPP LKDNLSLRHR
RTGARQNGGK VRHKRQALQD MARPLKQWLY KHRDNPYPTK TEKILLALGS QMTLVQVSNW
FANARRRLKN TVRQPDLSWA LRIKLYNKYV QGNAERLSVS SDGDSCSEDG ENPPRNHMNE
EGYSTPAHHT VIKGESSAIK AGGRPESRAA EDYVSPPKYK SSLLNRYLND SLRHVMATST
AMMGKTRRRN HSGSFSSNEF EEELVSPSSS ETEGTFVYRT DTPDIGSTKG DSAANRRGPS
KDDTYWKEIN AAMALTNLAQ GKDEVQGTTS CIIQKSSHIA EVKTVKLPLV QRF
