ID   MKX_PONAB               Reviewed;         352 AA.
AC   Q5R6P2;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Homeobox protein Mohawk;
GN   Name=MKX;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a morphogenetic regulator of cell adhesion.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TALE/IRO homeobox family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR860444; CAH92568.1; -; mRNA.
DR   RefSeq; NP_001126505.1; NM_001133033.1.
DR   AlphaFoldDB; Q5R6P2; -.
DR   SMR; Q5R6P2; -.
DR   STRING; 9601.ENSPPYP00000002530; -.
DR   PRIDE; Q5R6P2; -.
DR   GeneID; 100173493; -.
DR   KEGG; pon:100173493; -.
DR   CTD; 283078; -.
DR   eggNOG; KOG0773; Eukaryota.
DR   InParanoid; Q5R6P2; -.
DR   OrthoDB; 631777at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR008422; Homeobox_KN_domain.
DR   Pfam; PF05920; Homeobox_KN; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..352
FT                   /note="Homeobox protein Mohawk"
FT                   /id="PRO_0000268858"
FT   DNA_BIND        71..132
FT                   /note="Homeobox; TALE-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          19..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          157..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          245..272
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   352 AA;  39312 MW;  C59E9DC903201EFC CRC64;
     MNTIVFNKLS GAVLFEDGGA SERERGGRPY SGVLDSPHAR PEVGIADGPP LKDNLGLRHR
     RTGARQNGGK VRHKRQALQD MARPLKQWLY KHRDNPYPTK TEKILLALGP QMTLVQVSNW
     FANARRRLKN TVRQPDLSWA LRIKLYNKYV QGNAERLSVS SDDSCSEGGE NPPRTHMNEG
     GYNTPVHHPV IKSENSVIKA GVRPESRASE DYVAPPKYKS SLLNRYLNDS LRHVMATNTT
     MMGKTRQRNH SGSFSSNEFE EELVSPSSSE TEGNFVYRTD TLENGFNKGD SAANRKGPSK
     DDTYWKEINA AMALTNLAQG KDKLQGTTSC IIQKSSHIAE VKTVKVPLVQ HF