ID   ML67_NEUCR              Reviewed;         292 AA.
AC   Q7RYM5;
DT   02-DEC-2020, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Mitochondrial large ribosomal subunit protein mL67 {ECO:0000303|PubMed:16451194};
GN   Name=mL67; ORFNames=NCU00103;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
RN   [2]
RP   IDENTIFICATION, SUBUNIT, SUBCELLULAR LOCATION, AND FUNCTION.
RX   PubMed=16451194; DOI=10.1111/j.1574-6968.2005.00024.x;
RA   Gan X., Arita K., Isono S., Kitakawa M., Yoshino K., Yonezawa K., Kato A.,
RA   Inoue H., Isono K.;
RT   "Identification and comparative analysis of the large subunit mitochondrial
RT   ribosomal proteins of Neurospora crassa.";
RL   FEMS Microbiol. Lett. 254:157-164(2006).
CC   -!- FUNCTION: Component of the mitochondrial ribosome (mitoribosome), a
CC       dedicated translation machinery responsible for the synthesis of
CC       mitochondrial genome-encoded proteins, including at least some of the
CC       essential transmembrane subunits of the mitochondrial respiratory chain
CC       (PubMed:16451194). Also has extraribosomal functions, being involved in
CC       regulation of mitochondrial DNA recombination, maintenance and repair,
CC       and generation of homoplasmic cells (By similarity). Acts as
CC       transcription factor involved in regulation of RNA polymerase II-
CC       dependent transcription (By similarity). {ECO:0000250|UniProtKB:Q06630,
CC       ECO:0000269|PubMed:16451194}.
CC   -!- SUBUNIT: Component of the mitochondrial large ribosomal subunit (mt-
CC       LSU). {ECO:0000269|PubMed:16451194}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q06630}.
CC       Mitochondrion {ECO:0000269|PubMed:16451194}.
CC   -!- SIMILARITY: Belongs to the mitochondrion-specific ribosomal protein
CC       mL67 family. {ECO:0000305}.
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DR   EMBL; CM002238; EAA27991.1; -; Genomic_DNA.
DR   RefSeq; XP_957227.1; XM_952134.2.
DR   PDB; 6YWS; EM; 2.74 A; d=1-292.
DR   PDB; 6YWV; EM; 3.03 A; d=1-292.
DR   PDB; 6YWX; EM; 3.10 A; d=1-292.
DR   PDBsum; 6YWS; -.
DR   PDBsum; 6YWV; -.
DR   PDBsum; 6YWX; -.
DR   AlphaFoldDB; Q7RYM5; -.
DR   SMR; Q7RYM5; -.
DR   STRING; 5141.EFNCRP00000000457; -.
DR   EnsemblFungi; EAA27991; EAA27991; NCU00103.
DR   GeneID; 3873390; -.
DR   KEGG; ncr:NCU00103; -.
DR   VEuPathDB; FungiDB:NCU00103; -.
DR   HOGENOM; CLU_052835_1_0_1; -.
DR   InParanoid; Q7RYM5; -.
DR   Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0000150; F:DNA strand exchange activity; IEA:InterPro.
DR   GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; IEA:InterPro.
DR   InterPro; IPR024629; Mhr1.
DR   PANTHER; PTHR28184; PTHR28184; 1.
DR   Pfam; PF12829; Mhr1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Mitochondrion; Nucleus; Reference proteome;
KW   Ribonucleoprotein; Ribosomal protein; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..292
FT                   /note="Mitochondrial large ribosomal subunit protein mL67"
FT                   /id="PRO_0000451731"
FT   REGION          59..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   292 AA;  32457 MW;  C2E527E9F79C1FF5 CRC64;
     MNSVTTSTIG RLAFGVSRLS AVTNVAGAVR HASTHPTTAI PKPTTAVLKT SPLAEETAVE
     LKSPSRLQLK SEPGNKGNPK GHGDRIWAFH HIEQGQVIYS TKPVISHQHL IRQQPFTGKN
     LVPRKIRKDY WRPLAMIELA GKDQGAVGRS VYQKLREFKK RHELDWANEA EEGRKLMHKS
     KRERGQELND QKPNSVADMA AVLAGAGKGN LMWQVSRLGS SSELVGEIKK ASGAVEKGAV
     VDVKRQLRRA TVYWTNEQDK FHAREWSDNV SHEVGIPGEA EKKRMPIRMS SE