MLAA_HAEIN
ID MLAA_HAEIN Reviewed; 250 AA.
AC P44042;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Intermembrane phospholipid transport system lipoprotein MlaA {ECO:0000250|UniProtKB:P76506};
DE Flags: Precursor;
GN Name=mlaA {ECO:0000250|UniProtKB:P76506}; OrderedLocusNames=HI_0718;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Involved in a phospholipid transport pathway that maintains
CC lipid asymmetry in the outer membrane by retrograde trafficking of
CC phospholipids from the outer membrane to the inner membrane.
CC {ECO:0000250|UniProtKB:P76506}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000250|UniProtKB:P76506}; Lipid-anchor
CC {ECO:0000250|UniProtKB:P76506, ECO:0000255|PROSITE-ProRule:PRU00303}.
CC -!- SIMILARITY: Belongs to the MlaA family. {ECO:0000305}.
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DR EMBL; L42023; AAC22375.1; -; Genomic_DNA.
DR PIR; F64012; F64012.
DR RefSeq; NP_438876.1; NC_000907.1.
DR RefSeq; WP_005694634.1; NC_000907.1.
DR AlphaFoldDB; P44042; -.
DR SMR; P44042; -.
DR STRING; 71421.HI_0718; -.
DR DNASU; 949738; -.
DR EnsemblBacteria; AAC22375; AAC22375; HI_0718.
DR KEGG; hin:HI_0718; -.
DR PATRIC; fig|71421.8.peg.750; -.
DR eggNOG; COG2853; Bacteria.
DR HOGENOM; CLU_059326_3_2_6; -.
DR OMA; PYRYIDH; -.
DR PhylomeDB; P44042; -.
DR BioCyc; HINF71421:G1GJ1-752-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0120010; P:intermembrane phospholipid transfer; IBA:GO_Central.
DR InterPro; IPR007428; MlaA.
DR PANTHER; PTHR30035; PTHR30035; 1.
DR Pfam; PF04333; MlaA; 1.
DR PRINTS; PR01805; VACJLIPOPROT.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell outer membrane; Lipoprotein; Membrane; Palmitate; Reference proteome;
KW Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT CHAIN 19..250
FT /note="Intermembrane phospholipid transport system
FT lipoprotein MlaA"
FT /id="PRO_0000018212"
FT LIPID 19
FT /note="N-palmitoyl cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT LIPID 19
FT /note="S-diacylglycerol cysteine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ SEQUENCE 250 AA; 28110 MW; 7DDEC4FC587091BB CRC64;
MKTKTILTAL LSAIALTGCA NNNDTKQVSE RNDSLEDFNR TMWKFNYNVI DRYVLEPAAK
GWNNYVPKPI SSGLAGIANN LDEPVSFINR LIEGEPKKAF VHFNRFWINT VFGLGGFIDF
ASASKELRID NQRGFGETLG SYGVDAGTYI VLPIYNATTP RQLTGAVVDA AYMYPFWQWV
GGPWALVKYG VQAVDARAKN LNNAELLRQA QDPYITFREA YYQNLQFKVN DGKLVESKES
LPDDILKEID
