MLAC_HAEIN
ID MLAC_HAEIN Reviewed; 214 AA.
AC P45028;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Intermembrane phospholipid transport system binding protein MlaC {ECO:0000250|UniProtKB:P0ADV7};
DE Flags: Precursor;
GN Name=mlaC {ECO:0000250|UniProtKB:P0ADV7}; OrderedLocusNames=HI_1084;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=10675023;
RX DOI=10.1002/(sici)1522-2683(20000101)21:2<411::aid-elps411>3.0.co;2-4;
RA Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C.,
RA Fountoulakis M.;
RT "Two-dimensional map of the proteome of Haemophilus influenzae.";
RL Electrophoresis 21:411-429(2000).
CC -!- FUNCTION: Involved in a phospholipid transport pathway that maintains
CC lipid asymmetry in the outer membrane by retrograde trafficking of
CC phospholipids from the outer membrane to the inner membrane. May
CC transfer phospholipid across the periplasmic space and deliver it to
CC the MlaFEDB complex at the inner membrane.
CC {ECO:0000250|UniProtKB:P0ADV7}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250|UniProtKB:P0ADV7}.
CC -!- SIMILARITY: Belongs to the MlaC/ttg2D family. {ECO:0000305}.
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DR EMBL; L42023; AAC22740.1; -; Genomic_DNA.
DR PIR; B64166; B64166.
DR RefSeq; NP_439241.1; NC_000907.1.
DR RefSeq; WP_005693408.1; NC_000907.1.
DR AlphaFoldDB; P45028; -.
DR SMR; P45028; -.
DR STRING; 71421.HI_1084; -.
DR PRIDE; P45028; -.
DR EnsemblBacteria; AAC22740; AAC22740; HI_1084.
DR KEGG; hin:HI_1084; -.
DR PATRIC; fig|71421.8.peg.1129; -.
DR eggNOG; COG2854; Bacteria.
DR HOGENOM; CLU_094502_3_0_6; -.
DR OMA; ISKSIMT; -.
DR PhylomeDB; P45028; -.
DR BioCyc; HINF71421:G1GJ1-1119-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR Gene3D; 3.10.450.710; -; 1.
DR InterPro; IPR008869; MlaC/ttg2D.
DR InterPro; IPR042245; Tgt2/MlaC_sf.
DR PANTHER; PTHR36573; PTHR36573; 1.
DR Pfam; PF05494; MlaC; 1.
DR PIRSF; PIRSF004649; MlaC; 1.
PE 1: Evidence at protein level;
KW Periplasm; Reference proteome; Signal.
FT SIGNAL 1..28
FT /evidence="ECO:0000255"
FT CHAIN 29..214
FT /note="Intermembrane phospholipid transport system binding
FT protein MlaC"
FT /id="PRO_0000013917"
SQ SEQUENCE 214 AA; 24510 MW; 5D209A3646FBEE75 CRC64;
MNLIQLKKWF TILTFVLTAF LVTRTAIAET SPYVLMQQAA DKLFSDIQAN QSKIKQDPNY
LRTIVRNDLL PYVNLEYAGS KVLGSYYKST SAEQREKFFK TFGELIEQKY AQALTNYSNQ
KIQIESEKEL GDNNFINIRV NIIQANGVAP ILLYFKWRKG NKSGEWKVYD MVGAGVSMLE
DTIKNWVGIL NKQGIDTLIT KMQQSASQPI IFNQ