MLAC_SHIFL
ID MLAC_SHIFL Reviewed; 211 AA.
AC P0ADV8; P45390;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Intermembrane phospholipid transport system binding protein MlaC {ECO:0000250|UniProtKB:P0ADV7};
DE Flags: Precursor;
GN Name=mlaC {ECO:0000250|UniProtKB:P0ADV7}; OrderedLocusNames=SF3232, S3450;
OS Shigella flexneri.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shigella.
OX NCBI_TaxID=623;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=SA100 / Serotype 2a;
RX PubMed=9746567; DOI=10.1128/iai.66.10.4700-4710.1998;
RA Hong M., Gleason Y., Wyckoff E.E., Payne S.M.;
RT "Identification of two Shigella flexneri chromosomal loci involved in
RT intercellular spreading.";
RL Infect. Immun. 66:4700-4710(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=301 / Serotype 2a;
RX PubMed=12384590; DOI=10.1093/nar/gkf566;
RA Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT through comparison with genomes of Escherichia coli K12 and O157.";
RL Nucleic Acids Res. 30:4432-4441(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT "Complete genome sequence and comparative genomics of Shigella flexneri
RT serotype 2a strain 2457T.";
RL Infect. Immun. 71:2775-2786(2003).
CC -!- FUNCTION: Involved in a phospholipid transport pathway that maintains
CC lipid asymmetry in the outer membrane by retrograde trafficking of
CC phospholipids from the outer membrane to the inner membrane. May
CC transfer phospholipid across the periplasmic space and deliver it to
CC the MlaFEDB complex at the inner membrane.
CC {ECO:0000250|UniProtKB:P0ADV7}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250|UniProtKB:P0ADV7}.
CC -!- SIMILARITY: Belongs to the MlaC/ttg2D family. {ECO:0000305}.
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DR EMBL; AF053073; AAF21249.1; -; Genomic_DNA.
DR EMBL; AE005674; AAN44698.1; -; Genomic_DNA.
DR EMBL; AE014073; AAP18512.1; -; Genomic_DNA.
DR RefSeq; NP_708991.1; NC_004337.2.
DR RefSeq; WP_000476487.1; NZ_WPGW01000004.1.
DR AlphaFoldDB; P0ADV8; -.
DR SMR; P0ADV8; -.
DR STRING; 198214.SF3232; -.
DR EnsemblBacteria; AAN44698; AAN44698; SF3232.
DR EnsemblBacteria; AAP18512; AAP18512; S3450.
DR GeneID; 1027122; -.
DR GeneID; 66672906; -.
DR KEGG; sfl:SF3232; -.
DR KEGG; sfx:S3450; -.
DR PATRIC; fig|198214.7.peg.3833; -.
DR HOGENOM; CLU_094502_3_0_6; -.
DR OMA; ISKSIMT; -.
DR OrthoDB; 1716096at2; -.
DR Proteomes; UP000001006; Chromosome.
DR Proteomes; UP000002673; Chromosome.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR Gene3D; 3.10.450.710; -; 1.
DR InterPro; IPR008869; MlaC/ttg2D.
DR InterPro; IPR042245; Tgt2/MlaC_sf.
DR PANTHER; PTHR36573; PTHR36573; 1.
DR Pfam; PF05494; MlaC; 1.
DR PIRSF; PIRSF004649; MlaC; 1.
PE 3: Inferred from homology;
KW Periplasm; Reference proteome; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..211
FT /note="Intermembrane phospholipid transport system binding
FT protein MlaC"
FT /id="PRO_0000043112"
SQ SEQUENCE 211 AA; 23963 MW; A8F22EDFB0830763 CRC64;
MFKRLMMVAL LVIAPLSAAT AADQTNPYKL MDEAAQKTFD RLKNEQPQIR ANPDYLRTIV
DQELLPYVQV KYAGALVLGQ YYKSATPAQR EAYFAAFREY LKQAYGQALA MYHGQTYQIA
PEQPLGDKTI VPIRVTIIDP NGRPPVRLDF QWRKNSQTGN WQAYDMIAEG VSMITTKQNE
WGTLLRTKGI DGLTAQLKSI SQQKITLEEK K