MLAE_HAEIN
ID MLAE_HAEIN Reviewed; 261 AA.
AC P45030;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Intermembrane phospholipid transport system permease protein MlaE {ECO:0000250|UniProtKB:P64606};
GN Name=mlaE {ECO:0000250|UniProtKB:P64606}; OrderedLocusNames=HI_1086;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Part of the ABC transporter complex MlaFEDB, which is
CC involved in a phospholipid transport pathway that maintains lipid
CC asymmetry in the outer membrane by retrograde trafficking of
CC phospholipids from the outer membrane to the inner membrane. Probably
CC responsible for the translocation of the substrate across the membrane.
CC {ECO:0000250|UniProtKB:P64606}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (MlaF),
CC two transmembrane proteins (MlaE), two cytoplasmic solute-binding
CC proteins (MlaB) and six periplasmic solute-binding proteins (MlaD).
CC {ECO:0000250|UniProtKB:P64606}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P64606}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the MlaE permease family. {ECO:0000305}.
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DR EMBL; L42023; AAC22742.1; -; Genomic_DNA.
DR PIR; D64166; D64166.
DR RefSeq; NP_439243.1; NC_000907.1.
DR RefSeq; WP_005693411.1; NC_000907.1.
DR AlphaFoldDB; P45030; -.
DR SMR; P45030; -.
DR STRING; 71421.HI_1086; -.
DR PRIDE; P45030; -.
DR EnsemblBacteria; AAC22742; AAC22742; HI_1086.
DR KEGG; hin:HI_1086; -.
DR PATRIC; fig|71421.8.peg.1131; -.
DR eggNOG; COG0767; Bacteria.
DR HOGENOM; CLU_045686_1_1_6; -.
DR OMA; NYLVFPK; -.
DR PhylomeDB; P45030; -.
DR BioCyc; HINF71421:G1GJ1-1121-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005548; F:phospholipid transporter activity; IBA:GO_Central.
DR GO; GO:0015914; P:phospholipid transport; IBA:GO_Central.
DR InterPro; IPR003453; ABC_MlaE_Proteobac.
DR InterPro; IPR030802; Permease_MalE.
DR PANTHER; PTHR30188; PTHR30188; 1.
DR Pfam; PF02405; MlaE; 1.
DR TIGRFAMs; TIGR00056; TIGR00056; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..261
FT /note="Intermembrane phospholipid transport system permease
FT protein MlaE"
FT /id="PRO_0000169469"
FT TOPO_DOM 1..12
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P64606"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 34..49
FT /note="Periplasmic"
FT /evidence="ECO:0000250|UniProtKB:P64606"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P64606"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..198
FT /note="Periplasmic"
FT /evidence="ECO:0000250|UniProtKB:P64606"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250|UniProtKB:P64606"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..261
FT /note="Periplasmic"
FT /evidence="ECO:0000250|UniProtKB:P64606"
SQ SEQUENCE 261 AA; 28015 MW; 4BC3695F247A6BF6 CRC64;
MIVNFISALG KQVIDFFRAL GRAGFMLFGA LIGKPQIRKH FPLLVKQMHV LGVQSLLIIL
LSGLFIGMVL GLQGYVVLID FSAETSLGQL VALSLLRELG PVVTALLFAG RAGSALTAEI
GLMKATEQLS SLEMMAVDPL RRVIAPRFWA GVISMPVLSI LFIAIGIWGG SLVGVDWKGV
DSGSFWSVMQ NSVSWSYDIL NGFIKAVFFA VAVTWIALFN GYDCMPTSEG ISQATTRTVV
HASLVVLGLD FILTAIMFGA G
