MLC1_DROPS
ID MLC1_DROPS Reviewed; 155 AA.
AC Q24621; Q24620; Q29BG8;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Myosin light chain alkali;
GN Name=Mlc1; ORFNames=GA18996;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC TISSUE=Flight muscle, Head, and Larva;
RX PubMed=8355600; DOI=10.1093/oxfordjournals.molbev.a040043;
RA Leicht B.G., Lyckegaard E.M.S., Benedict C.M., Clark A.G.;
RT "Conservation of alternative splicing and genomic organization of the
RT myosin alkali light-chain (Mlc1) gene among Drosophila species.";
RL Mol. Biol. Evol. 10:769-790(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- SUBUNIT: Myosin is a hexamer of 2 heavy chains and 4 light chains.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Larval-adult; Synonyms=Larval-non-IFM;
CC IsoId=Q24621-1; Sequence=Displayed;
CC Name=Indirect flight muscle; Synonyms=Pupa, Adult flight muscle;
CC IsoId=Q24621-2; Sequence=VSP_003368;
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DR EMBL; L08052; AAA28691.1; -; Genomic_DNA.
DR EMBL; L08052; AAA28690.1; -; Genomic_DNA.
DR EMBL; CM000070; EAL27030.2; -; Genomic_DNA.
DR RefSeq; XP_001357894.2; XM_001357857.3.
DR RefSeq; XP_003736281.1; XM_003736233.2.
DR AlphaFoldDB; Q24621; -.
DR SMR; Q24621; -.
DR STRING; 7237.FBpp0282721; -.
DR EnsemblMetazoa; FBtr0284283; FBpp0282721; FBgn0012706. [Q24621-1]
DR EnsemblMetazoa; FBtr0303349; FBpp0292412; FBgn0012706. [Q24621-2]
DR GeneID; 4800662; -.
DR KEGG; dpo:Dpse_GA18996; -.
DR eggNOG; KOG0030; Eukaryota.
DR HOGENOM; CLU_061288_13_3_1; -.
DR InParanoid; Q24621; -.
DR OMA; PIFSQCK; -.
DR ChiTaRS; Mlc1; fly.
DR Proteomes; UP000001819; Chromosome 2.
DR Bgee; FBgn0012706; Expressed in adult organism and 3 other tissues.
DR GO; GO:0005859; C:muscle myosin complex; ISS:UniProtKB.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007498; P:mesoderm development; IEA:EnsemblMetazoa.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR029655; Mlc1.
DR PANTHER; PTHR23048:SF33; PTHR23048:SF33; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 4: Predicted;
KW Alternative splicing; Motor protein; Muscle protein; Myosin;
KW Reference proteome; Repeat.
FT CHAIN 1..155
FT /note="Myosin light chain alkali"
FT /id="PRO_0000198710"
FT DOMAIN 7..41
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 80..115
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT VAR_SEQ 142..155
FT /note="QFIQRLMSDPVVFD -> PFLARMCERPDMLK (in isoform
FT Indirect flight muscle)"
FT /evidence="ECO:0000305"
FT /id="VSP_003368"
SQ SEQUENCE 155 AA; 17546 MW; 28F93D88D6A28D69 CRC64;
MADVPKREIE NVEFVFEVMG SAGEGIDAVD LGDALRALNL NPTLALIEKM GGTKKRNEKK
IKMDEFLPIY SQVKKEKEQG CYEDFIECLK LYDKEENGTM MLAELQHALL ALGESLDDEQ
VETLFADCMD PEDDEGLIPY SQFIQRLMSD PVVFD
