MLC1_DROSI
ID MLC1_DROSI Reviewed; 155 AA.
AC Q24654; B4QY26; Q24653; Q24657; Q24659; Q27299; Q27429;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 3.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Myosin light chain alkali;
GN Name=Mlc1; ORFNames=GD18066;
OS Drosophila simulans (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC TISSUE=Flight muscle, Head, and Larva;
RX PubMed=8355600; DOI=10.1093/oxfordjournals.molbev.a040043;
RA Leicht B.G., Lyckegaard E.M.S., Benedict C.M., Clark A.G.;
RT "Conservation of alternative splicing and genomic organization of the
RT myosin alkali light-chain (Mlc1) gene among Drosophila species.";
RL Mol. Biol. Evol. 10:769-790(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 67-155.
RC STRAIN=3a, 4a, 5a, 6, 6a, 7, 7', and 9;
RX PubMed=8742636; DOI=10.1093/oxfordjournals.molbev.a025608;
RA Clark A.G., Leicht B.G., Muse S.V.;
RT "Length variation and secondary structure of introns in the Mlc1 gene in
RT six species of Drosophila.";
RL Mol. Biol. Evol. 13:471-482(1996).
CC -!- SUBUNIT: Myosin is a hexamer of 2 heavy chains and 4 light chains.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Larval-adult; Synonyms=Larval-non-IFM;
CC IsoId=Q24654-1; Sequence=Displayed;
CC Name=Indirect flight muscle; Synonyms=Pupa, Adult flight muscle;
CC IsoId=Q24654-2; Sequence=VSP_003370;
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DR EMBL; L08051; AAA28689.1; -; Genomic_DNA.
DR EMBL; L08051; AAA28688.1; -; Genomic_DNA.
DR EMBL; CM000364; EDX14674.1; -; Genomic_DNA.
DR EMBL; L49010; AAC37276.1; -; Genomic_DNA.
DR EMBL; L49010; AAC37277.1; -; Genomic_DNA.
DR EMBL; L49011; AAC37278.1; -; Genomic_DNA.
DR EMBL; L49011; AAC37279.1; -; Genomic_DNA.
DR EMBL; L49012; AAC37280.1; -; Genomic_DNA.
DR EMBL; L49012; AAC37281.1; -; Genomic_DNA.
DR EMBL; L49013; AAC37282.1; -; Genomic_DNA.
DR EMBL; L49013; AAC37283.1; -; Genomic_DNA.
DR EMBL; L49014; AAC37284.1; -; Genomic_DNA.
DR EMBL; L49014; AAC37285.1; -; Genomic_DNA.
DR EMBL; L49015; AAC37286.1; -; Genomic_DNA.
DR EMBL; L49016; AAC37287.1; -; Genomic_DNA.
DR EMBL; L49016; AAC37288.1; -; Genomic_DNA.
DR EMBL; L49017; AAC37290.1; -; Genomic_DNA.
DR RefSeq; XP_016036617.1; XM_016174552.1. [Q24654-1]
DR RefSeq; XP_016036618.1; XM_016174553.1. [Q24654-2]
DR AlphaFoldDB; Q24654; -.
DR SMR; Q24654; -.
DR STRING; 7240.Q24654; -.
DR EnsemblMetazoa; FBtr0217976; FBpp0216468; FBgn0012844. [Q24654-1]
DR EnsemblMetazoa; FBtr0348085; FBpp0313054; FBgn0012844. [Q24654-2]
DR GeneID; 6729868; -.
DR HOGENOM; CLU_061288_13_3_1; -.
DR OMA; PIFSQCK; -.
DR PhylomeDB; Q24654; -.
DR ChiTaRS; Mlc1; fly.
DR Proteomes; UP000000304; Chromosome 3r.
DR Bgee; FBgn0012844; Expressed in adult organism and 3 other tissues.
DR GO; GO:0005859; C:muscle myosin complex; ISS:UniProtKB.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007498; P:mesoderm development; IEA:EnsemblMetazoa.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR029655; Mlc1.
DR PANTHER; PTHR23048:SF33; PTHR23048:SF33; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 4: Predicted;
KW Alternative splicing; Motor protein; Muscle protein; Myosin;
KW Reference proteome; Repeat.
FT CHAIN 1..155
FT /note="Myosin light chain alkali"
FT /id="PRO_0000198712"
FT DOMAIN 7..41
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 80..115
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT VAR_SEQ 142..155
FT /note="QFVQRLMSDPVVFD -> PFLARMCDRPDQLK (in isoform
FT Indirect flight muscle)"
FT /evidence="ECO:0000305"
FT /id="VSP_003370"
SQ SEQUENCE 155 AA; 17542 MW; C5C82DD17995ED33 CRC64;
MADVPKREVE NVEFVFEVMG SPGEGIDAVD LGDALRALNL NPTLALIEKL GGTKKRNEKK
IKLDEFLPIY SQVKKEKEQG CYEDFIECLK LYDKEENGTM MLAELQHALL ALGESLDDEQ
VETLFADCMD PEDDEGFIPY SQFVQRLMSD PVVFD
