ID   MLEC_CHICK              Reviewed;         194 AA.
AC   P02606;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Myosin light chain 1, cardiac muscle;
DE   AltName: Full=Myosin light chain alkali 1;
DE            Short=Myosin light chain A1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   TISSUE=Heart ventricle;
RX   PubMed=3210243; DOI=10.1016/0022-2836(88)90115-5;
RA   Nakamura S., Nabeshima Y., Kobayashi H., Nabeshima Y., Nonomura Y.,
RA   Fujii-Kuriyama Y.;
RT   "Single chicken cardiac myosin alkali light-chain gene generates two
RT   different mRNAs by alternative splicing of a complex exon.";
RL   J. Mol. Biol. 203:895-904(1988).
RN   [2]
RP   PROTEIN SEQUENCE OF 3-194.
RX   PubMed=6772448; DOI=10.1111/j.1432-1033.1980.tb06064.x;
RA   Maita T., Umegane T., Kato Y., Matsuda G.;
RT   "Amino-acid sequence of the L-1 light chain of chicken cardiac-muscle
RT   myosin.";
RL   Eur. J. Biochem. 107:565-575(1980).
CC   -!- SUBUNIT: Myosin is a hexamer of 2 heavy chains and 4 light chains.
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DR   EMBL; X13861; CAA32072.1; -; mRNA.
DR   EMBL; X13862; CAA32073.1; -; mRNA.
DR   EMBL; X13863; CAA32074.1; -; Genomic_DNA.
DR   EMBL; X13864; CAA32075.1; -; Genomic_DNA.
DR   EMBL; X13865; CAA32075.1; JOINED; Genomic_DNA.
DR   EMBL; X13866; CAA32075.1; JOINED; Genomic_DNA.
DR   EMBL; X13867; CAA32075.1; JOINED; Genomic_DNA.
DR   PIR; S01843; MOCHLC.
DR   RefSeq; NP_990490.1; NM_205159.1.
DR   AlphaFoldDB; P02606; -.
DR   SMR; P02606; -.
DR   STRING; 9031.ENSGALP00000043277; -.
DR   PaxDb; P02606; -.
DR   GeneID; 396067; -.
DR   KEGG; gga:396067; -.
DR   CTD; 4634; -.
DR   VEuPathDB; HostDB:geneid_396067; -.
DR   eggNOG; KOG0030; Eukaryota.
DR   OrthoDB; 1470794at2759; -.
DR   PhylomeDB; P02606; -.
DR   PRO; PR:P02606; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0031672; C:A band; IBA:GO_Central.
DR   GO; GO:0016460; C:myosin II complex; IBA:GO_Central.
DR   GO; GO:0003785; F:actin monomer binding; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0060048; P:cardiac muscle contraction; IBA:GO_Central.
DR   GO; GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IBA:GO_Central.
DR   CDD; cd00051; EFh; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Motor protein; Muscle protein; Myosin;
KW   Reference proteome; Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT   CHAIN           2..194
FT                   /note="Myosin light chain 1, cardiac muscle"
FT                   /id="PRO_0000198703"
FT   DOMAIN          48..85
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          127..162
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          162..194
FT                   /note="EF-hand 3"
FT                   /evidence="ECO:0000305"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..38
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="Blocked amino end (Pro)"
FT   CONFLICT        144
FT                   /note="N -> D (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        157
FT                   /note="R -> A (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   194 AA;  21996 MW;  F6502D56DE2A5CB5 CRC64;
     MPPKKPEPKK APEPKKEEPK PAPKPAEPEP KKEVEFNPAS IKVEFTPDQI EEFKEAFSLF
     DRTPKSEMKI TYAQCGDVLR ALGQNPTQAE VMKVLGRPKQ EEMNSKMIDF ETFLPMLQHI
     SKTKDTGTYE DFVEGLRVFD KEGNGTVMGA ELRHVLRTLG ERLTEEEVDK LMAGQEDANG
     CINYEAFVKH IMAN