MLO10_ARATH
ID MLO10_ARATH Reviewed; 569 AA.
AC Q9FKY5;
DT 19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=MLO-like protein 10;
DE Short=AtMlo10;
GN Name=MLO10; OrderedLocusNames=At5g65970; ORFNames=K2A18.3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12569425; DOI=10.1007/s00239-002-2382-5;
RA Devoto A., Hartmann H.A., Piffanelli P., Elliott C., Simmons C.,
RA Taramino G., Goh C.-S., Cohen F.E., Emerson B.C., Schulze-Lefert P.,
RA Panstruga R.;
RT "Molecular phylogeny and evolution of the plant-specific seven-
RT transmembrane MLO family.";
RL J. Mol. Evol. 56:77-88(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT features of the regions of 1,381,565 bp covered by twenty one physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:131-145(1998).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: May be involved in modulation of pathogen defense and leaf
CC cell death. Activity seems to be regulated by Ca(2+)-dependent
CC calmodulin binding and seems not to require heterotrimeric G proteins
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- DOMAIN: The C-terminus contains a calmodulin-binding domain, which
CC binds calmodulin in a calcium-dependent fashion. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MLO family. {ECO:0000305}.
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DR EMBL; AF369571; AAK53803.1; -; mRNA.
DR EMBL; AB011474; BAB10402.1; -; Genomic_DNA.
DR EMBL; CP002688; AED98133.1; -; Genomic_DNA.
DR RefSeq; NP_201398.1; NM_125994.2.
DR AlphaFoldDB; Q9FKY5; -.
DR SMR; Q9FKY5; -.
DR BioGRID; 21969; 5.
DR IntAct; Q9FKY5; 1.
DR STRING; 3702.AT5G65970.1; -.
DR PaxDb; Q9FKY5; -.
DR PRIDE; Q9FKY5; -.
DR ProteomicsDB; 250933; -.
DR EnsemblPlants; AT5G65970.1; AT5G65970.1; AT5G65970.
DR GeneID; 836727; -.
DR Gramene; AT5G65970.1; AT5G65970.1; AT5G65970.
DR KEGG; ath:AT5G65970; -.
DR Araport; AT5G65970; -.
DR TAIR; locus:2156837; AT5G65970.
DR eggNOG; ENOG502QPZ5; Eukaryota.
DR HOGENOM; CLU_024720_1_0_1; -.
DR InParanoid; Q9FKY5; -.
DR OMA; TASYMSN; -.
DR OrthoDB; 603362at2759; -.
DR PhylomeDB; Q9FKY5; -.
DR PRO; PR:Q9FKY5; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FKY5; baseline and differential.
DR Genevisible; Q9FKY5; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR InterPro; IPR004326; Mlo.
DR PANTHER; PTHR31942; PTHR31942; 1.
DR Pfam; PF03094; Mlo; 1.
PE 2: Evidence at transcript level;
KW Calmodulin-binding; Membrane; Pathogenesis-related protein; Plant defense;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..569
FT /note="MLO-like protein 10"
FT /id="PRO_0000209940"
FT TOPO_DOM 1..41
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..163
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..286
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 308
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..329
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 330..372
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 373..393
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 394..413
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 414..434
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 435..569
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 447..468
FT /note="Calmodulin-binding"
SQ SEQUENCE 569 AA; 64483 MW; 82C026D55C2BF2A2 CRC64;
MATRCFWCWT TLLFCSQLLT GFARASSAGG AKEKGLSQTP TWAVALVCTF FILVSVLLEK
ALHRVATWLW EKHKNSLLEA LEKIKAELMI LGFISLLLTF GEQYILKICI PEKAAASMLP
CPAPSTHDQD KTHRRRLAAA TTSSRCDEGH EPLIPATGLH QLHILLFFMA AFHILYSFIT
MMLGRLKIRG WKKWEQETCS HDYEFSIDPS RFRLTHETSF VRQHSSFWTK IPFFFYAGCF
LQQFFRSVGR TDYLTLRHGF IAAHLAPGRK FDFQKYIKRS LEDDFKVVVG ISPLLWASFV
IFLLLNVNGW EALFWASILP VLIILAVSTK LQAILTRMAL GITERHAVVQ GIPLVHGSDK
YFWFNRPQLL LHLLHFALFQ NAFQLTYFFW VWYSFGLKSC FHTDFKLVIV KLSLGVGALI
LCSYITLPLY ALVTQMGSNM KKAVFDEQMA KALKKWHMTV KKKKGKARKP PTETLGVSDT
VSTSTSSFHA SGATLLRSKT TGHSTASYMS NFEDQSMSDL EAEPLSPEPI EGHTLVRVGD
QNTEIEYTGD ISPGNQFSFV KNVPANDID
