MLO11_ARATH
ID MLO11_ARATH Reviewed; 573 AA.
AC Q9FI00;
DT 19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=MLO-like protein 11;
DE Short=AtMlo11;
GN Name=MLO11; OrderedLocusNames=At5g53760; ORFNames=MGN6.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12569425; DOI=10.1007/s00239-002-2382-5;
RA Devoto A., Hartmann H.A., Piffanelli P., Elliott C., Simmons C.,
RA Taramino G., Goh C.-S., Cohen F.E., Emerson B.C., Schulze-Lefert P.,
RA Panstruga R.;
RT "Molecular phylogeny and evolution of the plant-specific seven-
RT transmembrane MLO family.";
RL J. Mol. Evol. 56:77-88(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10470850; DOI=10.1093/dnares/6.3.183;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Kotani H.,
RA Miyajima N., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. IX. Sequence
RT features of the regions of 1,011,550 bp covered by seventeen P1 and TAC
RT clones.";
RL DNA Res. 6:183-195(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- FUNCTION: May be involved in modulation of pathogen defense and leaf
CC cell death. Activity seems to be regulated by Ca(2+)-dependent
CC calmodulin binding and seems not to require heterotrimeric G proteins
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- DOMAIN: The C-terminus contains a calmodulin-binding domain, which
CC binds calmodulin in a calcium-dependent fashion. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MLO family. {ECO:0000305}.
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DR EMBL; AF369572; AAK53804.1; -; mRNA.
DR EMBL; AB017066; BAB09548.1; -; Genomic_DNA.
DR EMBL; CP002688; AED96403.1; -; Genomic_DNA.
DR EMBL; CP002688; AED96404.1; -; Genomic_DNA.
DR EMBL; AY057502; AAL09743.1; -; mRNA.
DR EMBL; BT000434; AAN17411.1; -; mRNA.
DR EMBL; BT002581; AAO00941.1; -; mRNA.
DR RefSeq; NP_001032070.1; NM_001036993.2.
DR RefSeq; NP_200187.1; NM_124755.3.
DR AlphaFoldDB; Q9FI00; -.
DR BioGRID; 20701; 3.
DR IntAct; Q9FI00; 2.
DR STRING; 3702.AT5G53760.1; -.
DR PaxDb; Q9FI00; -.
DR PRIDE; Q9FI00; -.
DR ProteomicsDB; 238376; -.
DR EnsemblPlants; AT5G53760.1; AT5G53760.1; AT5G53760.
DR EnsemblPlants; AT5G53760.2; AT5G53760.2; AT5G53760.
DR GeneID; 835457; -.
DR Gramene; AT5G53760.1; AT5G53760.1; AT5G53760.
DR Gramene; AT5G53760.2; AT5G53760.2; AT5G53760.
DR KEGG; ath:AT5G53760; -.
DR Araport; AT5G53760; -.
DR TAIR; locus:2164037; AT5G53760.
DR eggNOG; KOG0017; Eukaryota.
DR HOGENOM; CLU_024720_2_1_1; -.
DR InParanoid; Q9FI00; -.
DR OMA; RRMRMFP; -.
DR OrthoDB; 448417at2759; -.
DR PhylomeDB; Q9FI00; -.
DR PRO; PR:Q9FI00; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FI00; baseline and differential.
DR Genevisible; Q9FI00; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR InterPro; IPR004326; Mlo.
DR PANTHER; PTHR31942; PTHR31942; 1.
DR Pfam; PF03094; Mlo; 1.
PE 2: Evidence at transcript level;
KW Calmodulin-binding; Membrane; Pathogenesis-related protein; Plant defense;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..573
FT /note="MLO-like protein 11"
FT /id="PRO_0000209941"
FT TOPO_DOM 1..19
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..40
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..163
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 185..287
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..329
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 330..371
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 372..392
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 393..411
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 412..432
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 433..573
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 446..467
FT /note="Calmodulin-binding"
FT REGION 500..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 554..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 573 AA; 66350 MW; B02CCB8E0CA6BEFE CRC64;
MGEGEENGNE ADSNERSLAL SPTWSVAIVL TVFVVVSLIV ERSIYRLSTW LRKTKRKPMF
AALEKMKEEL MLLGFISLLL TATSSTIANI CVPSSFYNDR FLPCTRSEIQ EELESGSTVK
RNLLTKSLFF NIFRRRLDVI KRTTCSEGHE PFVSYEGLEQ LHRFIFIMAV THVTYSCLTM
LLAIVKIHSW RIWEDVARLD RHDCLTAVAR EKIFRRQTTF VQYHTSAPLA KNRILIWVTC
FFRQFGRSVD RSDYLTLRKG FIVNHHLTLK YDFHSYMIRS MEEEFQRIVG VSGPLWGFVV
AFMLFNIKGS NLYFWIAIIP VTLVLLVGAK LQHVIATLAL ENAGLTEYPS GVKLRPRDEL
FWFNKPELLL SLIHFILFQN SFELASFFWF WWQFGYSSCF LKNHYLVYFR LLLGFAGQFL
CSYSTLPLYA LVTQMGTNYK AALIPQRIRE TIRGWGKATR RKRRHGLYGD DSTVRTETST
IASLEEYDHQ VLDVTETSFE QQRKQQEQGT TELELQPIQP RNDCVPNDTS SRVGTPLLRP
WLSISSPTTT IELRSEPMET LSRSSSLPSE KRV
