MLO14_ARATH
ID MLO14_ARATH Reviewed; 554 AA.
AC Q94KB1; Q9LQY2;
DT 19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=MLO-like protein 14;
DE Short=AtMlo14;
GN Name=MLO14; OrderedLocusNames=At1g26700; ORFNames=T24P13.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12569425; DOI=10.1007/s00239-002-2382-5;
RA Devoto A., Hartmann H.A., Piffanelli P., Elliott C., Simmons C.,
RA Taramino G., Goh C.-S., Cohen F.E., Emerson B.C., Schulze-Lefert P.,
RA Panstruga R.;
RT "Molecular phylogeny and evolution of the plant-specific seven-
RT transmembrane MLO family.";
RL J. Mol. Evol. 56:77-88(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: May be involved in modulation of pathogen defense and leaf
CC cell death. Activity seems to be regulated by Ca(2+)-dependent
CC calmodulin binding and seems not to require heterotrimeric G proteins
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- DOMAIN: The C-terminus contains a calmodulin-binding domain, which
CC binds calmodulin in a calcium-dependent fashion. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MLO family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF87028.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF369575; AAK53807.1; -; mRNA.
DR EMBL; AC006535; AAF87028.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE30722.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM57918.1; -; Genomic_DNA.
DR PIR; H86393; H86393.
DR RefSeq; NP_001319086.1; NM_001332726.1.
DR RefSeq; NP_564257.1; NM_102433.1.
DR AlphaFoldDB; Q94KB1; -.
DR BioGRID; 24447; 8.
DR IntAct; Q94KB1; 8.
DR STRING; 3702.AT1G26700.1; -.
DR PaxDb; Q94KB1; -.
DR PRIDE; Q94KB1; -.
DR EnsemblPlants; AT1G26700.1; AT1G26700.1; AT1G26700.
DR EnsemblPlants; AT1G26700.2; AT1G26700.2; AT1G26700.
DR GeneID; 839211; -.
DR Gramene; AT1G26700.1; AT1G26700.1; AT1G26700.
DR Gramene; AT1G26700.2; AT1G26700.2; AT1G26700.
DR KEGG; ath:AT1G26700; -.
DR Araport; AT1G26700; -.
DR TAIR; locus:2200640; AT1G26700.
DR eggNOG; KOG0017; Eukaryota.
DR HOGENOM; CLU_024720_2_1_1; -.
DR InParanoid; Q94KB1; -.
DR OMA; IWEDEVH; -.
DR OrthoDB; 448417at2759; -.
DR PhylomeDB; Q94KB1; -.
DR PRO; PR:Q94KB1; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q94KB1; baseline and differential.
DR Genevisible; Q94KB1; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR InterPro; IPR004326; Mlo.
DR PANTHER; PTHR31942; PTHR31942; 1.
DR Pfam; PF03094; Mlo; 1.
PE 2: Evidence at transcript level;
KW Calmodulin-binding; Membrane; Pathogenesis-related protein; Plant defense;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..554
FT /note="MLO-like protein 14"
FT /id="PRO_0000209944"
FT TOPO_DOM 1..13
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 14..34
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..63
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 85..158
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..281
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 303
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 304..324
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 325..366
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 367..387
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 388..406
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 407..427
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 428..554
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 441..462
FT /note="Calmodulin-binding"
SQ SEQUENCE 554 AA; 63923 MW; 2CA658B8EA6EF3D2 CRC64;
MREETEPSER TLGLTPTWSV ATVLTIFVFV SLIVERSIHR LSNWLQKTKR KPLFAALEKM
KEELMLLGFI SLLLTATSST IANICVSSSF HNDRFVPCTP SEINEELEST ISTVKRTQLT
RSLFLHTLRR RLSGIGEDTC SEGHEPFLSY EGMEQLHRFI FIMAVTHVTY SCLTMLLAIV
KIHRWRIWED EVHMDRNDCL TVVAREKIFR RQTTFVQYHT SAPLVKNRLL IWVICFFRQF
GHSVVRSDYL TLRKGFIMNH HLTLTYDFHS YMIRSMEEEF QKIVGVSGPL WGFVVGFMLF
NIKGSNLYFW LAIIPITLVL LVGAKLQHVI ATLALENASI TEYASGIKLR PRDELFWFKK
PELLLSLIHF IQFQNAFELA SFFWFWWQFG YNSCFLRNHL LVYLRLILGF SGQFLCSYST
LPLYALVTQM GTNYKAALLP QRVRETINGW GKATRRKRRH GLYGDDSTIR TETSTIASVD
EYNDQVLDVS ETSPVQDNEL ELQLIRGACG NSSSVETPIL RPCASISSTT FSRLQTETTD
SLSRSSSLPM RREC
