MLO4_ARATH
ID MLO4_ARATH Reviewed; 573 AA.
AC O23693; Q94KB8;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2003, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=MLO-like protein 4;
DE Short=AtMlo4;
GN Name=MLO4; OrderedLocusNames=At1g11000; ORFNames=T19D16.26;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12569425; DOI=10.1007/s00239-002-2382-5;
RA Devoto A., Hartmann H.A., Piffanelli P., Elliott C., Simmons C.,
RA Taramino G., Goh C.-S., Cohen F.E., Emerson B.C., Schulze-Lefert P.,
RA Panstruga R.;
RT "Molecular phylogeny and evolution of the plant-specific seven-
RT transmembrane MLO family.";
RL J. Mol. Evol. 56:77-88(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: May be involved in modulation of pathogen defense and leaf
CC cell death. Activity seems to be regulated by Ca(2+)-dependent
CC calmodulin binding and seems not to require heterotrimeric G proteins
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- DOMAIN: The C-terminus contains a calmodulin-binding domain, which
CC binds calmodulin in a calcium-dependent fashion. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MLO family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB65495.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF369565; AAK53797.1; -; mRNA.
DR EMBL; U95973; AAB65495.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28674.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM58486.1; -; Genomic_DNA.
DR PIR; A86244; A86244.
DR RefSeq; NP_001320916.1; NM_001331948.1.
DR RefSeq; NP_563882.1; NM_100975.3.
DR AlphaFoldDB; O23693; -.
DR BioGRID; 22883; 26.
DR IntAct; O23693; 23.
DR STRING; 3702.AT1G11000.1; -.
DR PaxDb; O23693; -.
DR PRIDE; O23693; -.
DR ProteomicsDB; 238342; -.
DR EnsemblPlants; AT1G11000.1; AT1G11000.1; AT1G11000.
DR EnsemblPlants; AT1G11000.3; AT1G11000.3; AT1G11000.
DR GeneID; 837643; -.
DR Gramene; AT1G11000.1; AT1G11000.1; AT1G11000.
DR Gramene; AT1G11000.3; AT1G11000.3; AT1G11000.
DR KEGG; ath:AT1G11000; -.
DR Araport; AT1G11000; -.
DR TAIR; locus:2197439; AT1G11000.
DR eggNOG; ENOG502QQK2; Eukaryota.
DR HOGENOM; CLU_024720_2_1_1; -.
DR InParanoid; O23693; -.
DR OrthoDB; 448417at2759; -.
DR PhylomeDB; O23693; -.
DR PRO; PR:O23693; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; O23693; baseline and differential.
DR Genevisible; O23693; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR InterPro; IPR004326; Mlo.
DR PANTHER; PTHR31942; PTHR31942; 1.
DR Pfam; PF03094; Mlo; 1.
PE 2: Evidence at transcript level;
KW Calmodulin-binding; Membrane; Pathogenesis-related protein; Plant defense;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..573
FT /note="MLO-like protein 4"
FT /id="PRO_0000209934"
FT TOPO_DOM 1..13
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 14..34
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..62
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 63..83
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 84..151
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 173..271
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 315..359
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 360..380
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 381..399
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 400..420
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 421..573
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 434..455
FT /note="Calmodulin-binding"
FT REGION 542..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 573 AA; 65466 MW; 38BA74C1DB7BD1B6 CRC64;
MEHMMKEGRS LAETPTYSVA SVVTVLVFVC FLVERAIYRF GKWLKKTRRK ALFTSLEKMK
EELMLLGLIS LLLSQSARWI SEICVNSSLF NSKFYICSEE DYGIHKKVLL EHTSSTNQSS
LPHHGIHEAS HQCGHGREPF VSYEGLEQLL RFLFVLGITH VLYSGIAIGL AMSKIYSWRK
WEAQAIIMAE SDIHAKKTKV MKRQSTFVFH HASHPWSNNR FLIWMLCFLR QFRGSIRKSD
YFALRLGFLT KHNLPFTYNF HMYMVRTMED EFHGIVGISW PLWVYAIVCI CINVHGLNMY
FWISFVPAIL VMLVGTKLEH VVSKLALEVK EQQTGTSNGA QVKPRDGLFW FGKPEILLRL
IQFIIFQNAF EMATFIWFLW GIKERSCFMK NHVMISSRLI SGVLVQFWCS YGTVPLNVIV
TQMGSRHKKA VIAESVRDSL HSWCKRVKER SKHTRSVCSL DTATIDERDE MTVGTLSRSS
SMTSLNQITI NSIDQAESIF GAAASSSSPQ DGYTSRVEEY LSETYNNIGS IPPLNDEIEI
EIEGEEDNGG RGSGSDENNG DAGETLLELF RRT
