MLO6_ARATH
ID MLO6_ARATH Reviewed; 583 AA.
AC Q94KB7; Q9SY94;
DT 19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 2.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=MLO-like protein 6;
DE Short=AtMlo6;
GN Name=MLO6; OrderedLocusNames=At1g61560; ORFNames=T25B24.9;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12569425; DOI=10.1007/s00239-002-2382-5;
RA Devoto A., Hartmann H.A., Piffanelli P., Elliott C., Simmons C.,
RA Taramino G., Goh C.-S., Cohen F.E., Emerson B.C., Schulze-Lefert P.,
RA Panstruga R.;
RT "Molecular phylogeny and evolution of the plant-specific seven-
RT transmembrane MLO family.";
RL J. Mol. Evol. 56:77-88(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: May be involved in modulation of pathogen defense and leaf
CC cell death. Activity seems to be regulated by Ca(2+)-dependent
CC calmodulin binding and seems not to require heterotrimeric G proteins
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q94KB7-1; Sequence=Displayed;
CC -!- DOMAIN: The C-terminus contains a calmodulin-binding domain, which
CC binds calmodulin in a calcium-dependent fashion. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MLO family. {ECO:0000305}.
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DR EMBL; AF369567; AAK53799.2; -; mRNA.
DR EMBL; AC005850; AAD25552.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33851.1; -; Genomic_DNA.
DR PIR; H96640; H96640.
DR RefSeq; NP_176350.1; NM_104836.2. [Q94KB7-1]
DR AlphaFoldDB; Q94KB7; -.
DR SMR; Q94KB7; -.
DR BioGRID; 27673; 13.
DR IntAct; Q94KB7; 11.
DR STRING; 3702.AT1G61560.1; -.
DR iPTMnet; Q94KB7; -.
DR PaxDb; Q94KB7; -.
DR PRIDE; Q94KB7; -.
DR ProteomicsDB; 250934; -. [Q94KB7-1]
DR EnsemblPlants; AT1G61560.1; AT1G61560.1; AT1G61560. [Q94KB7-1]
DR GeneID; 842450; -.
DR Gramene; AT1G61560.1; AT1G61560.1; AT1G61560. [Q94KB7-1]
DR KEGG; ath:AT1G61560; -.
DR Araport; AT1G61560; -.
DR TAIR; locus:2200883; AT1G61560.
DR eggNOG; ENOG502QVKX; Eukaryota.
DR HOGENOM; CLU_024720_1_0_1; -.
DR InParanoid; Q94KB7; -.
DR OrthoDB; 387177at2759; -.
DR PhylomeDB; Q94KB7; -.
DR PRO; PR:Q94KB7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q94KB7; baseline and differential.
DR Genevisible; Q94KB7; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:TAIR.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IMP:TAIR.
DR InterPro; IPR004326; Mlo.
DR PANTHER; PTHR31942; PTHR31942; 1.
DR Pfam; PF03094; Mlo; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calmodulin-binding; Membrane;
KW Pathogenesis-related protein; Plant defense; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..583
FT /note="MLO-like protein 6"
FT /id="PRO_0000209936"
FT TOPO_DOM 1..15
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 16..36
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..61
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 83..161
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 183..284
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 306..314
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 336..368
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 369..389
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 390..411
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 412..432
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 433..583
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 447..468
FT /note="Calmodulin-binding"
FT REGION 461..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 469..489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..520
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..552
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 583 AA; 67226 MW; E6A3683CA8BB9150 CRC64;
MADQVKEKTL EETSTWAVAV VCFVLLLISI VIEKLIHKIG SWFKKKNKKA LYEALEKVKA
ELMLMGFISL LLTIGQGYIS NICIPKNIAA SMHPCSASEE ARKYGKKDVP KEDEEENLRR
KLLQLVDSLI PRRSLATKGY DKCAEKGKVA FVSAYGMHQL HIFIFVLAVC HVIYCIVTYA
LGKTKMRRWK KWEEETKTIE YQYSHDPERF RFARDTSFGR RHLSFWSKST ITLWIVCFFR
QFFRSVTKVD YLTLRHGFIM AHLAPGSDAR FDFRKYIQRS LEEDFKTIVE INPVIWFIAV
LFLLTNTNGL NSYLWLPFIP FIVILIVGTK LQVIITKLGL RIQEKGDVVK GTPLVQPGDH
FFWFGRPRFI LFLIHLVLFT NAFQLAFFVW STYEFGLKNC FHESRVDVII RISIGLLVQI
LCSYVTLPLY ALVTQMGSKM KPTVFNERVA TALKSWHHTA KKNIKHGRTS ESTTPFSSRP
TTPTHGSSPI HLLRNAPHKR SRSVDESFAN SFSPRNSDFD SWDPESQHET AETSNSNHRS
RFGEEESEKK FVSSSVELPP GPGQIRTQHE ISTISLRDFS FKR
