MLO9_ARATH
ID MLO9_ARATH Reviewed; 460 AA.
AC Q94KB4; Q9C855; Q9C8E5;
DT 19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2003, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=MLO-like protein 9;
DE Short=AtMlo9;
GN Name=MLO9; OrderedLocusNames=At1g42560; ORFNames=F8D11.2, T8D8.5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE OF 122-460.
RX PubMed=12569425; DOI=10.1007/s00239-002-2382-5;
RA Devoto A., Hartmann H.A., Piffanelli P., Elliott C., Simmons C.,
RA Taramino G., Goh C.-S., Cohen F.E., Emerson B.C., Schulze-Lefert P.,
RA Panstruga R.;
RT "Molecular phylogeny and evolution of the plant-specific seven-
RT transmembrane MLO family.";
RL J. Mol. Evol. 56:77-88(2003).
CC -!- FUNCTION: May be involved in modulation of pathogen defense and leaf
CC cell death. Activity seems to be regulated by Ca(2+)-dependent
CC calmodulin binding and seems not to require heterotrimeric G proteins
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- DOMAIN: The C-terminus contains a calmodulin-binding domain, which
CC binds calmodulin in a calcium-dependent fashion. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MLO family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG51234.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAG51314.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC025815; AAG51314.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC035249; AAG51234.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE31927.1; -; Genomic_DNA.
DR EMBL; AF369570; AAK53802.1; -; mRNA.
DR PIR; E96495; E96495.
DR RefSeq; NP_174980.3; NM_103440.4.
DR AlphaFoldDB; Q94KB4; -.
DR BioGRID; 26089; 10.
DR IntAct; Q94KB4; 7.
DR STRING; 3702.AT1G42560.1; -.
DR TCDB; 9.B.197.1.3; the mildew resistance locus o (mlo) family.
DR PaxDb; Q94KB4; -.
DR PRIDE; Q94KB4; -.
DR ProteomicsDB; 238360; -.
DR EnsemblPlants; AT1G42560.1; AT1G42560.1; AT1G42560.
DR GeneID; 840861; -.
DR Gramene; AT1G42560.1; AT1G42560.1; AT1G42560.
DR KEGG; ath:AT1G42560; -.
DR Araport; AT1G42560; -.
DR TAIR; locus:2036650; AT1G42560.
DR eggNOG; ENOG502QPZ5; Eukaryota.
DR HOGENOM; CLU_024720_3_0_1; -.
DR InParanoid; Q94KB4; -.
DR OMA; VEGTHAM; -.
DR OrthoDB; 603362at2759; -.
DR PhylomeDB; Q94KB4; -.
DR PRO; PR:Q94KB4; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q94KB4; baseline and differential.
DR Genevisible; Q94KB4; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0043621; F:protein self-association; IPI:TAIR.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0010183; P:pollen tube guidance; IGI:TAIR.
DR GO; GO:0072659; P:protein localization to plasma membrane; IGI:TAIR.
DR GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR InterPro; IPR004326; Mlo.
DR PANTHER; PTHR31942; PTHR31942; 1.
DR Pfam; PF03094; Mlo; 1.
PE 2: Evidence at transcript level;
KW Calmodulin-binding; Membrane; Pathogenesis-related protein; Plant defense;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..460
FT /note="MLO-like protein 9"
FT /id="PRO_0000209939"
FT TOPO_DOM 1..21
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 22..42
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 43..67
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..158
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..289
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 311..315
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 337..366
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 367..387
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 388..398
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 399..419
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 420..460
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 441..460
FT /note="Calmodulin-binding"
SQ SEQUENCE 460 AA; 53210 MW; 739705B1DC08D34F CRC64;
MAGGGGGGGG EGPRQLDQTP TWAVSTVCGV IILISIILEL IIHKVGEVFE RKKKKALFEA
LEKIKNELMV LGFISLLLTF GQNYIASICV PSRYGHAMSF CGPYDGPSED DRKKLKKTDH
AMRILYSVQR RSLADAPPVN CKKDYVALIS LNALHQVHIF IFFLAVFHVI YSAITMMLGR
AKIRGWKVWE QEVIHEQEMM NDPSRFRLTH ETSFVREHVN SWASNKFFFY VMCFFRQILR
SVRKSDYLTM RHGFISVHLA PGMKFDFQKY IKRSLEDDFK VVVGIRPELW AFVMLFLLFD
VHGWYVTAVI TMIPPLLTLA IGTKLQAIIS YMALEIQERH AVIQGMPVVN VSDQHFWFEK
PDLVLHMIHF VLFQNAFEIT YFFWIWYEFG LRSCFHHHFG LIIIRVCLGV GVQFLCSYIT
LPLYALVTQM GSTMKRSVFD EQTSKALEQW HKKARKKNEK
