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MLOH1_HORVU
ID   MLOH1_HORVU             Reviewed;         544 AA.
AC   O49873;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=MLO protein homolog 1;
GN   Name=MLO-H1;
OS   Hordeum vulgare (Barley).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Hordeinae; Hordeum.
OX   NCBI_TaxID=4513;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cv. Igri;
RA   Panstruga R.;
RL   Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in modulation of pathogen defense and leaf
CC       cell death. Activity seems to be regulated by Ca(2+)-dependent
CC       calmodulin binding and seems not to require heterotrimeric G proteins
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- DOMAIN: The C-terminus contains a calmodulin-binding domain, which
CC       binds calmodulin in a calcium-dependent fashion. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MLO family. {ECO:0000305}.
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DR   EMBL; Z95496; CAB08860.1; -; Genomic_DNA.
DR   PIR; T05952; T05952.
DR   AlphaFoldDB; O49873; -.
DR   ExpressionAtlas; O49873; differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR   InterPro; IPR004326; Mlo.
DR   PANTHER; PTHR31942; PTHR31942; 1.
DR   Pfam; PF03094; Mlo; 1.
PE   3: Inferred from homology;
KW   Calmodulin-binding; Membrane; Pathogenesis-related protein; Plant defense;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..544
FT                   /note="MLO protein homolog 1"
FT                   /id="PRO_0000209929"
FT   TOPO_DOM        1..15
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        16..36
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        37..59
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        81..154
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        176..284
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        285..305
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        306..326
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        327..359
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        360..380
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        381..402
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        403..423
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        424..544
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          437..458
FT                   /note="Calmodulin-binding"
FT   REGION          485..544
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   544 AA;  60875 MW;  D4FBCDD2A2A87796 CRC64;
     MAGPAGGREL SDTPTWAVAV VCAVMILVSV AMEHALHKLG HWFHKWRKKA LGEALEKMKA
     ELMLVGFISL LLIVTQDPVS RICISKEAGE KMLPCKPYDG AGGGKGKDNH RRLLWLQGES
     ETHRRFLAAP AGVDVCAKQG KVALMSAGSM HQLHIFIFVL AVFHVLYSVV TMTLSRLKMK
     QWKKWESETA SLEYQFANDP SRCRFTHQTT LVRRHLGLSS TPGVRWVVAF FRQFFTSVTK
     VDYLTLRQGF INAHLSQGNR FDFHKYIKRS LEDDFKVVVR ISLKLWFVAV LILFLDFDGI
     GTLLWMSVVP LVILLWVGTK LEMVIMEMAQ EIHDRESVVK GAPAVEPSNK YFWFNRPDWV
     LFLMHLTLFQ NAFQMAHFVW TVATPGLKKC YHEKMAMSIA KVVLGVAAQI LCSYITFPLY
     ALVTQMGSHM KRSIFDEQTA KALTNWRKMA KEKKKARDAA MLMAQMGGGA TPSVGSSPVH
     LLHKAGARSD DPQSVPASPR AEKEGGGVQH PARKVPPCDG WRSASSPALD AHIPGADFGF
     STQR
 
 
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