MLOH1_ORYSI
ID MLOH1_ORYSI Reviewed; 540 AA.
AC A2YD22; O49914; Q67W42; Q84TU0;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 2.
DT 25-MAY-2022, entry version 49.
DE RecName: Full=MLO protein homolog 1;
DE AltName: Full=OsMLO1;
GN Name=MLO1; Synonyms=MLO-H1; ORFNames=OsI_022215;
OS Oryza sativa subsp. indica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39946;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=cv. IRBB21;
RX PubMed=12569425; DOI=10.1007/s00239-002-2382-5;
RA Devoto A., Hartmann H.A., Piffanelli P., Elliott C., Simmons C.,
RA Taramino G., Goh C.-S., Cohen F.E., Emerson B.C., Schulze-Lefert P.,
RA Panstruga R.;
RT "Molecular phylogeny and evolution of the plant-specific seven-
RT transmembrane MLO family.";
RL J. Mol. Evol. 56:77-88(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 93-11;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
CC -!- FUNCTION: May be involved in modulation of pathogen defense and leaf
CC cell death. Activity seems to be regulated by Ca(2+)-dependent
CC calmodulin binding and seems not to require heterotrimeric G proteins
CC (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- DOMAIN: The C-terminus contains a calmodulin-binding domain, which
CC binds calmodulin in a calcium-dependent fashion. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MLO family. {ECO:0000305}.
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DR EMBL; Z95353; CAB08606.2; -; Genomic_DNA.
DR EMBL; CM000131; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; T03797; T03797.
DR AlphaFoldDB; A2YD22; -.
DR SMR; A2YD22; -.
DR STRING; 39946.A2YD22; -.
DR Proteomes; UP000007015; Chromosome 6.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR InterPro; IPR004326; Mlo.
DR PANTHER; PTHR31942; PTHR31942; 1.
DR Pfam; PF03094; Mlo; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding; Membrane; Pathogenesis-related protein; Plant defense;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..540
FT /note="MLO protein homolog 1"
FT /id="PRO_0000300236"
FT TOPO_DOM 1..16
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..60
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..142
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 164..265
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 287
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..347
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 348..368
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 369..383
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..404
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 405..540
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 426..447
FT /note="Calmodulin-binding"
FT REGION 468..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 540 AA; 60707 MW; 7FB576B03A91ADBE CRC64;
MAGGRSGSRE LPETPTWAVA VVCAVLVLVS AAMEHGLHNL SHWFRRRQKK AMGDALDKIK
AELMLLGFIS LLLTVAQAPI SKICIPKSAA NILLPCKAGQ DAIEEEAASG RRSLAGAGGG
DYCSKFDGKV ALMSAKSMHQ LHIFIFVLAV FHVTYCIITM GLGRLKMKKW KKWESQTNSL
EYQFAIDPSR FRFTHQTSFV KRHLGSFSST PGLRWIVAFF RQFFGSVTKV DYLTMRQGFI
NAHLSQNSKF DFHKYIKRSL EDDFKVVVGI SLPLWFVGIL VLFLDIHGLG TLIWISFVPL
IIVLLVGTKL EMVIMEMAQE IQDRATVIQG APMVEPSNKY FWFNRPDWVL FFIHLTLFHN
AFQMAHFVWT MATPGLKKCF HENIWLSIVE VIVGISLQVL CSYITFPLYA LVTQMGSNMK
KTIFEEQTMK ALMNWRKKAM EKKKVRDADA FLAQMSVDFA TPASSRSASP VHLLQDHRAR
SDDPPSPITV ASPPAPEEDM YPVPAAAASR QLLDDPPDRR WMASSSADIA DSDFSFSAQR
