MLP1_DROME
ID MLP1_DROME Reviewed; 92 AA.
AC P53777; Q1RKS4; Q9W1B4;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Muscle LIM protein 1;
GN Name=Mlp60A; Synonyms=LIM2, MLP1; ORFNames=CG3220;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=7954791; DOI=10.1016/0092-8674(94)90192-9;
RA Arber S., Halder G., Caroni P.;
RT "Muscle LIM protein, a novel essential regulator of myogenesis, promotes
RT myogenic differentiation.";
RL Cell 79:221-231(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8794860; DOI=10.1083/jcb.134.5.1179;
RA Stronach B.E., Siegrist S.E., Beckerle M.C.;
RT "Two muscle-specific LIM proteins in Drosophila.";
RL J. Cell Biol. 134:1179-1195(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo, and Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Positive regulator of myogenesis.
CC {ECO:0000269|PubMed:7954791}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC -!- TISSUE SPECIFICITY: In the embryo, expression is restricted to the
CC somatic, visceral, and pharyngeal muscles. Within the somatic
CC musculature, MLP60 is distributed throughout the muscle fibers. There
CC is no expression in cardiac mesoderm or in fat body.
CC {ECO:0000269|PubMed:7954791}.
CC -!- DEVELOPMENTAL STAGE: Expression is biphasic, peaking late in
CC embryogenesis (16-24 hours embryos) and during the larval to pupal
CC transition, when the musculature is differentiating. Found in
CC developing muscles of the visceral and somatic mesoderm subsequent to
CC the formation of the muscle precursor cells. Decreased levels are still
CC detectable in adults. {ECO:0000269|PubMed:7954791}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABE73307.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; X81192; CAA57064.1; -; mRNA.
DR EMBL; X91244; CAA62626.1; -; mRNA.
DR EMBL; AE013599; AAF47158.2; -; Genomic_DNA.
DR EMBL; AY071073; AAL48695.1; -; mRNA.
DR EMBL; AY113643; AAM29648.1; -; mRNA.
DR EMBL; BT025136; ABE73307.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001286820.1; NM_001299891.1.
DR RefSeq; NP_788435.1; NM_176255.3.
DR AlphaFoldDB; P53777; -.
DR STRING; 7227.FBpp0288975; -.
DR PaxDb; P53777; -.
DR PRIDE; P53777; -.
DR DNASU; 37853; -.
DR EnsemblMetazoa; FBtr0299696; FBpp0288974; FBgn0259209.
DR EnsemblMetazoa; FBtr0344996; FBpp0311250; FBgn0259209.
DR GeneID; 37853; -.
DR KEGG; dme:Dmel_CG42309; -.
DR CTD; 37853; -.
DR FlyBase; FBgn0259209; Mlp60A.
DR VEuPathDB; VectorBase:FBgn0259209; -.
DR eggNOG; KOG1700; Eukaryota.
DR GeneTree; ENSGT00940000171011; -.
DR HOGENOM; CLU_037060_0_0_1; -.
DR InParanoid; P53777; -.
DR OMA; CPRCGIY; -.
DR PhylomeDB; P53777; -.
DR BioGRID-ORCS; 37853; 0 hits in 3 CRISPR screens.
DR ChiTaRS; Mlp60A; fly.
DR GenomeRNAi; 37853; -.
DR PRO; PR:P53777; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0259209; Expressed in crop (Drosophila) and 29 other tissues.
DR ExpressionAtlas; P53777; baseline and differential.
DR Genevisible; P53777; DM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0030018; C:Z disc; IDA:FlyBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR GO; GO:0060537; P:muscle tissue development; IEP:FlyBase.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00412; LIM; 1.
DR SMART; SM00132; LIM; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Developmental protein; Differentiation; LIM domain;
KW Metal-binding; Myogenesis; Nucleus; Reference proteome; Repeat; Zinc.
FT CHAIN 1..92
FT /note="Muscle LIM protein 1"
FT /id="PRO_0000075851"
FT DOMAIN 11..62
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT MOTIF 65..70
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 92 AA; 9958 MW; FDDBDDA1A90065A8 CRC64;
MPFVPVETPK CPACGKSVYA AEERVAGGYK FHKTCFKCSM CNKALDSTNC TEHEKELFCK
NCHGRKYGPK GYGFGGGAGC LSTDTGAHLN RE
