位置:首页 > 蛋白库 > MLPA_BORBU
MLPA_BORBU
ID   MLPA_BORBU              Reviewed;         148 AA.
AC   H7C7P1;
DT   13-FEB-2019, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2012, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Lipoprotein MlpA {ECO:0000303|PubMed:10948116};
DE   Flags: Precursor;
GN   Name=mlpA; OrderedLocusNames=BB_P28;
OS   Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)
OS   (Borrelia burgdorferi).
OG   Plasmid cp32-1.
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX   NCBI_TaxID=224326;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX   PubMed=9403685; DOI=10.1038/37551;
RA   Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA   Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L.,
RA   Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L.,
RA   Peterson J.D., Kerlavage A.R., Quackenbush J., Salzberg S.L., Hanson M.,
RA   van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F.,
RA   Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C.,
RA   Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B.,
RA   Smith H.O., Venter J.C.;
RT   "Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.";
RL   Nature 390:580-586(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX   PubMed=10672174; DOI=10.1046/j.1365-2958.2000.01698.x;
RA   Casjens S., Palmer N., van Vugt R., Huang W.M., Stevenson B., Rosa P.,
RA   Lathigra R., Sutton G.G., Peterson J.D., Dodson R.J., Haft D.H.,
RA   Hickey E.K., Gwinn M.L., White O., Fraser C.M.;
RT   "A bacterial genome in flux: the twelve linear and nine circular
RT   extrachromosomal DNAs in an infectious isolate of the Lyme disease
RT   spirochete Borrelia burgdorferi.";
RL   Mol. Microbiol. 35:490-516(2000).
RN   [3]
RP   FUNCTION, ANTIGENICITY, SUBCELLULAR LOCATION, AND INDUCTION AT 35 DEGREES
RP   CELSIUS.
RC   STRAIN=B31-4A; PLASMID=cp32-1;
RX   PubMed=10948116; DOI=10.1128/iai.68.9.4992-5001.2000;
RA   Porcella S.F., Fitzpatrick C.A., Bono J.L.;
RT   "Expression and immunological analysis of the plasmid-borne mlp genes of
RT   Borrelia burgdorferi strain B31.";
RL   Infect. Immun. 68:4992-5001(2000).
CC   -!- FUNCTION: An outer membrane protein that may participate in
CC       pathogenesis. Some human Lyme disease patients have antibodies against
CC       this protein (PubMed:10948116). The Mlp proteins probably undergo
CC       intragenic recombination, generating new alleles (Probable).
CC       {ECO:0000269|PubMed:10948116, ECO:0000305|PubMed:10948116}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000305|PubMed:10948116}; Lipid-anchor
CC       {ECO:0000305|PubMed:10948116}.
CC   -!- INDUCTION: Strongly induced when grown at 35 degrees Celsius.
CC       {ECO:0000269|PubMed:10948116}.
CC   -!- SIMILARITY: Belongs to the Multicopy lipoprotein (Mlp) family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE001575; AAF07417.1; -; Genomic_DNA.
DR   RefSeq; NP_051189.1; NC_000948.1.
DR   RefSeq; WP_010883731.1; NC_000948.1.
DR   PDB; 6QBI; NMR; -; A=51-148.
DR   PDBsum; 6QBI; -.
DR   AlphaFoldDB; H7C7P1; -.
DR   BMRB; H7C7P1; -.
DR   SMR; H7C7P1; -.
DR   EnsemblBacteria; AAF07417; AAF07417; BB_P28.
DR   KEGG; bbu:BB_P28; -.
DR   PATRIC; fig|224326.49.peg.28; -.
DR   HOGENOM; CLU_134260_0_0_12; -.
DR   Proteomes; UP000001807; Plasmid cp32-1.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004983; Mlp.
DR   Pfam; PF03304; Mlp; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell outer membrane; Lipoprotein; Membrane; Palmitate;
KW   Plasmid; Reference proteome; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000305"
FT   CHAIN           18..148
FT                   /note="Lipoprotein MlpA"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_5003609303"
FT   REGION          26..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..58
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           18
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000305"
FT   LIPID           18
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000305"
FT   HELIX           54..61
FT                   /evidence="ECO:0007829|PDB:6QBI"
FT   HELIX           64..77
FT                   /evidence="ECO:0007829|PDB:6QBI"
FT   HELIX           80..87
FT                   /evidence="ECO:0007829|PDB:6QBI"
FT   HELIX           91..106
FT                   /evidence="ECO:0007829|PDB:6QBI"
FT   STRAND          110..112
FT                   /evidence="ECO:0007829|PDB:6QBI"
FT   HELIX           113..125
FT                   /evidence="ECO:0007829|PDB:6QBI"
FT   STRAND          128..130
FT                   /evidence="ECO:0007829|PDB:6QBI"
FT   TURN            137..139
FT                   /evidence="ECO:0007829|PDB:6QBI"
FT   TURN            143..145
FT                   /evidence="ECO:0007829|PDB:6QBI"
SQ   SEQUENCE   148 AA;  16413 MW;  97C9ACAA3026EAFF CRC64;
     MKIINILFCL FLLLLNSCNS NDNDTLKNNA QQTKSRGKRD LTQKEATPEK PKSKEELLRE
     KLSEDQKTHL DWLKEALGND GEFDKFLGYD ESKIKTALDH IKSELDKCNG NDADQQKTTF
     KQTVQGALSG GIDGFGSNNA VTTCGNGS
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024