ID   MLPC_BORBU              Reviewed;         148 AA.
AC   Q9S0H7;
DT   13-FEB-2019, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Lipoprotein MlpC {ECO:0000303|PubMed:10948116};
DE   Flags: Precursor;
GN   Name=mlpC {ECO:0000303|PubMed:10948116}; OrderedLocusNames=BB_S30;
OS   Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)
OS   (Borrelia burgdorferi).
OG   Plasmid cp32-3.
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX   NCBI_TaxID=224326;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX   PubMed=9403685; DOI=10.1038/37551;
RA   Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA   Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L.,
RA   Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L.,
RA   Peterson J.D., Kerlavage A.R., Quackenbush J., Salzberg S.L., Hanson M.,
RA   van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F.,
RA   Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C.,
RA   Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B.,
RA   Smith H.O., Venter J.C.;
RT   "Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.";
RL   Nature 390:580-586(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX   PubMed=10672174; DOI=10.1046/j.1365-2958.2000.01698.x;
RA   Casjens S., Palmer N., van Vugt R., Huang W.M., Stevenson B., Rosa P.,
RA   Lathigra R., Sutton G.G., Peterson J.D., Dodson R.J., Haft D.H.,
RA   Hickey E.K., Gwinn M.L., White O., Fraser C.M.;
RT   "A bacterial genome in flux: the twelve linear and nine circular
RT   extrachromosomal DNAs in an infectious isolate of the Lyme disease
RT   spirochete Borrelia burgdorferi.";
RL   Mol. Microbiol. 35:490-516(2000).
RN   [3]
RP   FUNCTION, ANTIGENICITY, SUBCELLULAR LOCATION, AND INDUCTION AT 35 DEGREES
RP   CELSIUS.
RC   STRAIN=B31-4A; PLASMID=cp32-3;
RX   PubMed=10948116; DOI=10.1128/iai.68.9.4992-5001.2000;
RA   Porcella S.F., Fitzpatrick C.A., Bono J.L.;
RT   "Expression and immunological analysis of the plasmid-borne mlp genes of
RT   Borrelia burgdorferi strain B31.";
RL   Infect. Immun. 68:4992-5001(2000).
CC   -!- FUNCTION: An outer membrane protein that may participate in
CC       pathogenesis. Some human Lyme disease patients have antibodies against
CC       this protein (PubMed:10948116). The Mlp proteins probably undergo
CC       intragenic recombination, generating new alleles (Probable).
CC       {ECO:0000269|PubMed:10948116, ECO:0000305|PubMed:10948116}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000305|PubMed:10948116}; Lipid-anchor
CC       {ECO:0000305|PubMed:10948116}.
CC   -!- INDUCTION: Induced when grown at 35 degrees Celsius.
CC       {ECO:0000269|PubMed:10948116}.
CC   -!- SIMILARITY: Belongs to the Multicopy lipoprotein (Mlp) family.
CC       {ECO:0000305}.
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DR   EMBL; AE001576; AAF07449.1; -; Genomic_DNA.
DR   RefSeq; NP_051233.1; NC_000949.1.
DR   RefSeq; WP_010883753.1; NC_000949.1.
DR   AlphaFoldDB; Q9S0H7; -.
DR   SMR; Q9S0H7; -.
DR   EnsemblBacteria; AAF07449; AAF07449; BB_S30.
DR   KEGG; bbu:BB_S30; -.
DR   PATRIC; fig|224326.49.peg.71; -.
DR   HOGENOM; CLU_134260_0_0_12; -.
DR   OMA; CDQEKNT; -.
DR   Proteomes; UP000001807; Plasmid cp32-3.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004983; Mlp.
DR   Pfam; PF03304; Mlp; 1.
PE   2: Evidence at transcript level;
KW   Cell outer membrane; Lipoprotein; Membrane; Palmitate; Plasmid;
KW   Reference proteome; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000305"
FT   CHAIN           18..148
FT                   /note="Lipoprotein MlpC"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_5004332389"
FT   REGION          26..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..61
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           18
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000305"
FT   LIPID           18
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   148 AA;  16731 MW;  1D406F6BC310895C CRC64;
     MKIINILFCL FLLMLNGCNS NDNDTLKNNA QQTKRRGKRD LTQKETTQEK PKSKEELLRE
     KLSDDQKTHL DWLKPALTGA GEFDKFLEND DDKIKSALDH IKTQLDSCNG DQAEQQKTTF
     KTVVTEFFKN GDIDNFATGA VSNCNNGG