ID   MLPD_BORBU              Reviewed;         140 AA.
AC   Q9S0E8;
DT   13-FEB-2019, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Lipoprotein MlpD {ECO:0000303|PubMed:10948116};
DE   Flags: Precursor;
GN   Name=mlpD {ECO:0000303|PubMed:10948116}; OrderedLocusNames=BB_R28;
OS   Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)
OS   (Borrelia burgdorferi).
OG   Plasmid cp32-4.
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX   NCBI_TaxID=224326;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX   PubMed=9403685; DOI=10.1038/37551;
RA   Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA   Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L.,
RA   Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L.,
RA   Peterson J.D., Kerlavage A.R., Quackenbush J., Salzberg S.L., Hanson M.,
RA   van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F.,
RA   Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C.,
RA   Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B.,
RA   Smith H.O., Venter J.C.;
RT   "Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.";
RL   Nature 390:580-586(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX   PubMed=10672174; DOI=10.1046/j.1365-2958.2000.01698.x;
RA   Casjens S., Palmer N., van Vugt R., Huang W.M., Stevenson B., Rosa P.,
RA   Lathigra R., Sutton G.G., Peterson J.D., Dodson R.J., Haft D.H.,
RA   Hickey E.K., Gwinn M.L., White O., Fraser C.M.;
RT   "A bacterial genome in flux: the twelve linear and nine circular
RT   extrachromosomal DNAs in an infectious isolate of the Lyme disease
RT   spirochete Borrelia burgdorferi.";
RL   Mol. Microbiol. 35:490-516(2000).
RN   [3]
RP   FUNCTION, ANTIGENICITY, SUBCELLULAR LOCATION, AND INDUCTION AT 35 DEGREES
RP   CELSIUS.
RC   STRAIN=B31-4A; PLASMID=cp32-4;
RX   PubMed=10948116; DOI=10.1128/iai.68.9.4992-5001.2000;
RA   Porcella S.F., Fitzpatrick C.A., Bono J.L.;
RT   "Expression and immunological analysis of the plasmid-borne mlp genes of
RT   Borrelia burgdorferi strain B31.";
RL   Infect. Immun. 68:4992-5001(2000).
CC   -!- FUNCTION: An outer membrane protein that may participate in
CC       pathogenesis. Some human Lyme disease patients have antibodies against
CC       this protein (PubMed:10948116). The Mlp proteins probably undergo
CC       intragenic recombination, generating new alleles (Probable).
CC       {ECO:0000269|PubMed:10948116, ECO:0000305|PubMed:10948116}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000305|PubMed:10948116}; Lipid-anchor
CC       {ECO:0000305|PubMed:10948116}.
CC   -!- INDUCTION: Weakly induced when grown at 35 degrees Celsius.
CC       {ECO:0000269|PubMed:10948116}.
CC   -!- SIMILARITY: Belongs to the Multicopy lipoprotein (Mlp) family.
CC       {ECO:0000305}.
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DR   EMBL; AE001577; AAF07504.1; -; Genomic_DNA.
DR   RefSeq; NP_051275.1; NC_000950.1.
DR   RefSeq; WP_010883780.1; NC_000950.1.
DR   AlphaFoldDB; Q9S0E8; -.
DR   SMR; Q9S0E8; -.
DR   EnsemblBacteria; AAF07504; AAF07504; BB_R28.
DR   KEGG; bbu:BB_R28; -.
DR   PATRIC; fig|224326.49.peg.115; -.
DR   HOGENOM; CLU_134260_0_0_12; -.
DR   OMA; ASSTCKN; -.
DR   Proteomes; UP000001807; Plasmid cp32-4.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004983; Mlp.
DR   Pfam; PF03304; Mlp; 1.
PE   2: Evidence at transcript level;
KW   Cell outer membrane; Lipoprotein; Membrane; Palmitate; Plasmid;
KW   Reference proteome; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000305"
FT   CHAIN           18..140
FT                   /note="Lipoprotein MlpD"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_5004336869"
FT   REGION          22..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..53
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           18
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000305"
FT   LIPID           18
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   140 AA;  15862 MW;  D45478F6595D9391 CRC64;
     MKIINILFCL FLLMLNGCNS NDTNNSQTKS RQKRDLTQKE ATQEKPKSKE ELLREKLNDN
     QKTHLDWLKE ALGNDGEFNK FLGYDESKIK SALDHIKSEL DSCTGDKVEN KNTFKQVVQE
     ALKGGIDGFE NTASSTCKNS