ID   MLPG_BORBU              Reviewed;         140 AA.
AC   Q9S083;
DT   13-FEB-2019, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Lipoprotein MlpG {ECO:0000303|PubMed:10948116};
DE   Flags: Precursor;
GN   Name=mlpG {ECO:0000303|PubMed:10948116}; OrderedLocusNames=BB_O28;
OS   Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)
OS   (Borrelia burgdorferi).
OG   Plasmid cp32-7.
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX   NCBI_TaxID=224326;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX   PubMed=9403685; DOI=10.1038/37551;
RA   Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA   Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L.,
RA   Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L.,
RA   Peterson J.D., Kerlavage A.R., Quackenbush J., Salzberg S.L., Hanson M.,
RA   van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F.,
RA   Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C.,
RA   Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B.,
RA   Smith H.O., Venter J.C.;
RT   "Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.";
RL   Nature 390:580-586(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX   PubMed=10672174; DOI=10.1046/j.1365-2958.2000.01698.x;
RA   Casjens S., Palmer N., van Vugt R., Huang W.M., Stevenson B., Rosa P.,
RA   Lathigra R., Sutton G.G., Peterson J.D., Dodson R.J., Haft D.H.,
RA   Hickey E.K., Gwinn M.L., White O., Fraser C.M.;
RT   "A bacterial genome in flux: the twelve linear and nine circular
RT   extrachromosomal DNAs in an infectious isolate of the Lyme disease
RT   spirochete Borrelia burgdorferi.";
RL   Mol. Microbiol. 35:490-516(2000).
RN   [3]
RP   FUNCTION, ANTIGENICITY, SUBCELLULAR LOCATION, AND INDUCTION AT 35 DEGREES
RP   CELSIUS.
RC   STRAIN=B31-4A; PLASMID=cp32-7;
RX   PubMed=10948116; DOI=10.1128/iai.68.9.4992-5001.2000;
RA   Porcella S.F., Fitzpatrick C.A., Bono J.L.;
RT   "Expression and immunological analysis of the plasmid-borne mlp genes of
RT   Borrelia burgdorferi strain B31.";
RL   Infect. Immun. 68:4992-5001(2000).
CC   -!- FUNCTION: An outer membrane protein that may participate in
CC       pathogenesis. Some human Lyme disease patients have antibodies against
CC       this protein (PubMed:10948116). The Mlp proteins probably undergo
CC       intragenic recombination, generating new alleles (Probable).
CC       {ECO:0000269|PubMed:10948116, ECO:0000305|PubMed:10948116}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane
CC       {ECO:0000305|PubMed:10948116}; Lipid-anchor
CC       {ECO:0000305|PubMed:10948116}.
CC   -!- INDUCTION: Weakly induced when grown at 35 degrees Celsius.
CC       {ECO:0000269|PubMed:10948116}.
CC   -!- SIMILARITY: Belongs to the Multicopy lipoprotein (Mlp) family.
CC       {ECO:0000305}.
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DR   EMBL; AE001579; AAF07597.1; -; Genomic_DNA.
DR   RefSeq; NP_051361.1; NC_000952.1.
DR   RefSeq; WP_010883847.1; NC_000952.1.
DR   AlphaFoldDB; Q9S083; -.
DR   SMR; Q9S083; -.
DR   EnsemblBacteria; AAF07597; AAF07597; BB_O28.
DR   KEGG; bbu:BB_O28; -.
DR   PATRIC; fig|224326.49.peg.198; -.
DR   HOGENOM; CLU_134260_0_0_12; -.
DR   OMA; EITPCAN; -.
DR   Proteomes; UP000001807; Plasmid cp32-7.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004983; Mlp.
DR   Pfam; PF03304; Mlp; 1.
PE   2: Evidence at transcript level;
KW   Cell outer membrane; Lipoprotein; Membrane; Palmitate; Plasmid;
KW   Reference proteome; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000305"
FT   CHAIN           18..140
FT                   /note="Lipoprotein MlpG"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_5004333248"
FT   REGION          22..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        27..57
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           18
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000305"
FT   LIPID           18
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   140 AA;  15800 MW;  E8BBB1A09F6DA848 CRC64;
     MKIINILFCL FLLMLNGCNS NDTNTKQTKS RQKRDLTQKE ATQEKPKSKS KEDLLREKLS
     DDQKTQLDWL KTALTGVGKF DKFLENDEGK IKSALEHIKT ELDKCNGNDE GKNTFKTTVQ
     GFFSGGNIDN FADQATATCN