MLR1_CAEEL
ID MLR1_CAEEL Reviewed; 170 AA.
AC P19625; Q9BL98;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Myosin regulatory light chain 1;
GN Name=mlc-1; ORFNames=C36E6.3;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=3244358; DOI=10.1128/mcb.8.12.5339-5349.1988;
RA Cummins C., Anderson P.;
RT "Regulatory myosin light-chain genes of Caenorhabditis elegans.";
RL Mol. Cell. Biol. 8:5339-5349(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBUNIT: Myosin is a hexamer of 2 heavy chains and 4 light chains (two
CC regulatory light chains and two essential light chains).
CC -!- MISCELLANEOUS: This chain binds calcium.
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DR EMBL; M23365; AAA28113.1; -; Genomic_DNA.
DR EMBL; FO080802; CCD66901.1; -; Genomic_DNA.
DR PIR; A31377; A31377.
DR RefSeq; NP_510829.2; NM_078428.6.
DR AlphaFoldDB; P19625; -.
DR SMR; P19625; -.
DR BioGRID; 46651; 7.
DR STRING; 6239.C36E6.3; -.
DR iPTMnet; P19625; -.
DR EPD; P19625; -.
DR PaxDb; P19625; -.
DR PeptideAtlas; P19625; -.
DR EnsemblMetazoa; C36E6.3.1; C36E6.3.1; WBGene00003369.
DR GeneID; 181776; -.
DR KEGG; cel:CELE_C36E6.3; -.
DR UCSC; C36E6.3; c. elegans.
DR CTD; 181776; -.
DR WormBase; C36E6.3; CE34269; WBGene00003369; mlc-1.
DR eggNOG; KOG0031; Eukaryota.
DR GeneTree; ENSGT00970000196646; -.
DR HOGENOM; CLU_061288_9_3_1; -.
DR InParanoid; P19625; -.
DR OMA; KRDCGKI; -.
DR OrthoDB; 1435392at2759; -.
DR PhylomeDB; P19625; -.
DR Reactome; R-CEL-5627123; RHO GTPases activate PAKs.
DR PRO; PR:P19625; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00003369; Expressed in larva and 10 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005859; C:muscle myosin complex; IDA:WormBase.
DR GO; GO:0016460; C:myosin II complex; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0032036; F:myosin heavy chain binding; IBA:GO_Central.
DR GO; GO:0040011; P:locomotion; IGI:WormBase.
DR GO; GO:0007517; P:muscle organ development; IGI:WormBase.
DR GO; GO:0002119; P:nematode larval development; IGI:WormBase.
DR GO; GO:0009791; P:post-embryonic development; IBA:GO_Central.
DR GO; GO:0006937; P:regulation of muscle contraction; IGI:WormBase.
DR CDD; cd00051; EFh; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR Pfam; PF13405; EF-hand_6; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 4: Predicted;
KW Calcium; Metal-binding; Motor protein; Muscle protein; Myosin;
KW Reference proteome; Repeat.
FT CHAIN 1..170
FT /note="Myosin regulatory light chain 1"
FT /id="PRO_0000198760"
FT DOMAIN 24..59
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 93..128
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 37
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 39
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 41
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 48
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 170 AA; 18617 MW; BD70E67D2560DF2A CRC64;
MSKAAKKKSS KKRSGSEAAQ FDQKTIQEFK EAFGIMDQNK DGIIDKSDLK DLYASMGQIA
PDSQIDAMIK EASGPINFTV FLTLFGERLT GTDPEATIIG AFAMFDKKDC GKIKEDDLIK
ILQNKRGEPL DEDEVKAMYK GKPPIEGGEV DYKAFAHLIT TGAQDELASA
