ID   MLRA_SALTS              Reviewed;         243 AA.
AC   E1WH94; P58398;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=HTH-type transcriptional regulator MlrA {ECO:0000305};
DE   AltName: Full=MerR-like regulator A {ECO:0000303|PubMed:11489123};
GN   Name=mlrA {ECO:0000303|PubMed:11489123}; OrderedLocusNames=SL1344_2138;
OS   Salmonella typhimurium (strain SL1344).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=216597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=SL1344;
RX   PubMed=11489123; DOI=10.1046/j.1365-2958.2001.02529.x;
RA   Brown P.K., Dozois C.M., Nickerson C.A., Zuppardo A., Terlonge J.,
RA   Curtiss R. III;
RT   "MlrA, a novel regulator of curli (AgF) and extracellular matrix synthesis
RT   by Escherichia coli and Salmonella enterica serovar Typhimurium.";
RL   Mol. Microbiol. 41:349-363(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SL1344;
RX   PubMed=22538806; DOI=10.1073/pnas.1201061109;
RA   Kroger C., Dillon S.C., Cameron A.D., Papenfort K., Sivasankaran S.K.,
RA   Hokamp K., Chao Y., Sittka A., Hebrard M., Handler K., Colgan A.,
RA   Leekitcharoenphon P., Langridge G.C., Lohan A.J., Loftus B., Lucchini S.,
RA   Ussery D.W., Dorman C.J., Thomson N.R., Vogel J., Hinton J.C.;
RT   "The transcriptional landscape and small RNAs of Salmonella enterica
RT   serovar Typhimurium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:E1277-E1286(2012).
CC   -!- FUNCTION: Transcriptional activator of csgD, which is required for
CC       production of the curli (AgF). {ECO:0000269|PubMed:11489123}.
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DR   EMBL; AF288175; AAK84660.1; -; Genomic_DNA.
DR   EMBL; FQ312003; CBW18234.1; -; Genomic_DNA.
DR   RefSeq; WP_001240418.1; NZ_QASL01000003.1.
DR   AlphaFoldDB; E1WH94; -.
DR   SMR; E1WH94; -.
DR   EnsemblBacteria; CBW18234; CBW18234; SL1344_2138.
DR   KEGG; sey:SL1344_2138; -.
DR   PATRIC; fig|216597.6.peg.2374; -.
DR   HOGENOM; CLU_045945_0_1_6; -.
DR   OMA; EQGWRVD; -.
DR   BioCyc; SENT216597:SL1344_RS11105-MON; -.
DR   Proteomes; UP000008962; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR000551; MerR-type_HTH_dom.
DR   Pfam; PF13411; MerR_1; 1.
DR   SMART; SM00422; HTH_MERR; 1.
DR   SUPFAM; SSF46955; SSF46955; 1.
DR   PROSITE; PS00552; HTH_MERR_1; 1.
DR   PROSITE; PS50937; HTH_MERR_2; 1.
PE   4: Predicted;
KW   Activator; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..243
FT                   /note="HTH-type transcriptional regulator MlrA"
FT                   /id="PRO_0000405423"
FT   DOMAIN          3..72
FT                   /note="HTH merR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT   DNA_BIND        6..25
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
SQ   SEQUENCE   243 AA;  27902 MW;  9DD9A896A50BA2A3 CRC64;
     MALYTIGEVA LLCDINPVTL RAWQRRYGLL KPQRTDGGHR LFNDADIDRI REIKRWIDNG
     VQVSKVKVLL SSDSSEQPNG WREQQEILLH YLQSSNLHSL RLWVKERGQD YPAQTLTTNL
     FVPLRRRLQC QQPALQALLG ILDGILINYI ALCLASARKK QGKDALVIGW NIHDTTRLWL
     EGWVASQQGW RIDVLAHSLS QFRPELFDGK TLLVWCGENQ TLAQQQQLLA WRAQGRDIHP
     LGV