ID   MLRA_SALTY              Reviewed;         243 AA.
AC   P0CL12; P58398;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=HTH-type transcriptional regulator MlrA {ECO:0000250|UniProtKB:E1WH94};
DE   AltName: Full=MerR-like regulator A {ECO:0000250|UniProtKB:E1WH94};
GN   Name=mlrA {ECO:0000250|UniProtKB:E1WH94}; OrderedLocusNames=STM2160;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Transcriptional activator of csgD, which is required for
CC       production of the curli (AgF). {ECO:0000250|UniProtKB:E1WH94}.
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DR   EMBL; AE006468; AAL21064.1; -; Genomic_DNA.
DR   RefSeq; NP_461105.1; NC_003197.2.
DR   RefSeq; WP_001240418.1; NC_003197.2.
DR   AlphaFoldDB; P0CL12; -.
DR   SMR; P0CL12; -.
DR   STRING; 99287.STM2160; -.
DR   PaxDb; P0CL12; -.
DR   EnsemblBacteria; AAL21064; AAL21064; STM2160.
DR   GeneID; 1253682; -.
DR   KEGG; stm:STM2160; -.
DR   PATRIC; fig|99287.12.peg.2286; -.
DR   HOGENOM; CLU_045945_0_1_6; -.
DR   OMA; EQGWRVD; -.
DR   PhylomeDB; P0CL12; -.
DR   BioCyc; SENT99287:STM2160-MON; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR000551; MerR-type_HTH_dom.
DR   Pfam; PF13411; MerR_1; 1.
DR   SMART; SM00422; HTH_MERR; 1.
DR   SUPFAM; SSF46955; SSF46955; 1.
DR   PROSITE; PS00552; HTH_MERR_1; 1.
DR   PROSITE; PS50937; HTH_MERR_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..243
FT                   /note="HTH-type transcriptional regulator MlrA"
FT                   /id="PRO_0000098145"
FT   DOMAIN          3..72
FT                   /note="HTH merR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
FT   DNA_BIND        6..25
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00254"
SQ   SEQUENCE   243 AA;  27902 MW;  9DD9A896A50BA2A3 CRC64;
     MALYTIGEVA LLCDINPVTL RAWQRRYGLL KPQRTDGGHR LFNDADIDRI REIKRWIDNG
     VQVSKVKVLL SSDSSEQPNG WREQQEILLH YLQSSNLHSL RLWVKERGQD YPAQTLTTNL
     FVPLRRRLQC QQPALQALLG ILDGILINYI ALCLASARKK QGKDALVIGW NIHDTTRLWL
     EGWVASQQGW RIDVLAHSLS QFRPELFDGK TLLVWCGENQ TLAQQQQLLA WRAQGRDIHP
     LGV