MLRP1_ACRMI
ID MLRP1_ACRMI Reviewed; 5145 AA.
AC B3EWZ5;
DT 09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT 09-JUL-2014, sequence version 1.
DT 03-AUG-2022, entry version 22.
DE RecName: Full=MAM and LDL-receptor class A domain-containing protein 1;
DE AltName: Full=Skeletal organic matrix MAM and LDL-receptor 1 {ECO:0000303|PubMed:23765379};
DE Short=SOM MAM and LDL-receptor 1 {ECO:0000303|PubMed:23765379};
DE Flags: Fragment;
OS Acropora millepora (Staghorn coral) (Heteropora millepora).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC Astrocoeniina; Acroporidae; Acropora.
OX NCBI_TaxID=45264;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=22490231; DOI=10.1111/j.1365-294x.2012.05554.x;
RA Moya A., Huisman L., Ball E.E., Hayward D.C., Grasso L.C., Chua C.M.,
RA Woo H.N., Gattuso J.P., Foret S., Miller D.J.;
RT "Whole transcriptome analysis of the coral Acropora millepora reveals
RT complex responses to CO(2)-driven acidification during the initiation of
RT calcification.";
RL Mol. Ecol. 21:2440-2454(2012).
RN [2] {ECO:0000305}
RP PROTEIN SEQUENCE OF 326-339; 719-737; 779-788; 1311-1334; 1350-1365;
RP 1416-1430; 1581-1595; 1712-1725; 1788-1817; 1940-1950; 2321-2331;
RP 2473-2484; 2646-2667; 2949-2960; 3157-3180; 3257-3278; 3436-3444; 3777-3785
RP AND 4005-4025, TISSUE SPECIFICITY, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=23765379; DOI=10.1093/molbev/mst109;
RA Ramos-Silva P., Kaandorp J., Huisman L., Marie B., Zanella-Cleon I.,
RA Guichard N., Miller D.J., Marin F.;
RT "The skeletal proteome of the coral Acropora millepora: the evolution of
RT calcification by co-option and domain shuffling.";
RL Mol. Biol. Evol. 30:2099-2112(2013).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:23765379}.
CC -!- TISSUE SPECIFICITY: Component of the acid-insoluble and acid-soluble
CC organic matrix of the aragonitic skeleton (at protein level).
CC {ECO:0000269|PubMed:23765379}.
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DR EMBL; JT011118; -; NOT_ANNOTATED_CDS; mRNA.
DR SMR; B3EWZ5; -.
DR PRIDE; B3EWZ5; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR CDD; cd00112; LDLa; 8.
DR CDD; cd06263; MAM; 27.
DR CDD; cd00111; Trefoil; 2.
DR Gene3D; 4.10.110.10; -; 2.
DR Gene3D; 4.10.400.10; -; 8.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR017994; P_trefoil_chordata.
DR InterPro; IPR017957; P_trefoil_CS.
DR InterPro; IPR000519; P_trefoil_dom.
DR InterPro; IPR044913; P_trefoil_dom_sf.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR Pfam; PF00057; Ldl_recept_a; 4.
DR Pfam; PF00629; MAM; 27.
DR Pfam; PF00088; Trefoil; 2.
DR PRINTS; PR00261; LDLRECEPTOR.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00680; PTREFOIL.
DR SMART; SM00192; LDLa; 8.
DR SMART; SM00137; MAM; 26.
DR SMART; SM00018; PD; 2.
DR SUPFAM; SSF49899; SSF49899; 28.
DR SUPFAM; SSF50370; SSF50370; 1.
DR SUPFAM; SSF57424; SSF57424; 7.
DR SUPFAM; SSF57492; SSF57492; 2.
DR PROSITE; PS01209; LDLRA_1; 6.
DR PROSITE; PS50068; LDLRA_2; 7.
DR PROSITE; PS00740; MAM_1; 2.
DR PROSITE; PS50060; MAM_2; 27.
DR PROSITE; PS00025; P_TREFOIL_1; 1.
DR PROSITE; PS51448; P_TREFOIL_2; 2.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Repeat; Secreted.
FT CHAIN <1..>5145
FT /note="MAM and LDL-receptor class A domain-containing
FT protein 1"
FT /id="PRO_0000429550"
FT DOMAIN <1..94
FT /note="MAM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 97..259
FT /note="MAM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 261..428
FT /note="MAM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 458..758
FT /note="MAM 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 760..923
FT /note="MAM 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 925..1092
FT /note="MAM 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 1120..1282
FT /note="MAM 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 1284..1451
FT /note="MAM 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 1453..1616
FT /note="MAM 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 1648..1808
FT /note="MAM 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 1810..1973
FT /note="MAM 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 2006..2169
FT /note="MAM 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 2171..2338
FT /note="MAM 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 2340..2505
FT /note="MAM 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 2525..2688
FT /note="MAM 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 2690..2852
FT /note="MAM 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 2854..3022
FT /note="MAM 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 3022..3068
FT /note="P-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DOMAIN 3069..3113
FT /note="P-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DOMAIN 3134..3299
FT /note="MAM 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 3301..3465
FT /note="MAM 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 3467..3635
FT /note="MAM 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 3680..3838
FT /note="MAM 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 3844..3879
FT /note="LDL-receptor class A 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3883..4045
FT /note="MAM 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 4065..4101
FT /note="LDL-receptor class A 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 4101..4262
FT /note="MAM 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 4267..4305
FT /note="LDL-receptor class A 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 4309..4472
FT /note="MAM 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 4490..4527
FT /note="LDL-receptor class A 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 4528..4689
FT /note="MAM 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 4695..4734
FT /note="LDL-receptor class A 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 4737..4897
FT /note="MAM 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 4911..4950
FT /note="LDL-receptor class A 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 4951..5113
FT /note="MAM 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 5110..>5145
FT /note="LDL-receptor class A 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT REGION 484..511
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2712..2733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 3024..3053
FT /evidence="ECO:0000255"
FT DISULFID 3035..3052
FT /evidence="ECO:0000255"
FT DISULFID 3046..3064
FT /evidence="ECO:0000255"
FT DISULFID 3071..3098
FT /evidence="ECO:0000255"
FT DISULFID 3082..3097
FT /evidence="ECO:0000255"
FT DISULFID 3092..3109
FT /evidence="ECO:0000255"
FT DISULFID 3845..3856
FT /evidence="ECO:0000255"
FT DISULFID 3851..3869
FT /evidence="ECO:0000255"
FT DISULFID 3863..3878
FT /evidence="ECO:0000255"
FT DISULFID 4066..4078
FT /evidence="ECO:0000255"
FT DISULFID 4073..4091
FT /evidence="ECO:0000255"
FT DISULFID 4085..4100
FT /evidence="ECO:0000255"
FT DISULFID 4268..4280
FT /evidence="ECO:0000255"
FT DISULFID 4275..4293
FT /evidence="ECO:0000255"
FT DISULFID 4287..4304
FT /evidence="ECO:0000255"
FT DISULFID 4491..4504
FT /evidence="ECO:0000255"
FT DISULFID 4498..4517
FT /evidence="ECO:0000255"
FT DISULFID 4511..4526
FT /evidence="ECO:0000255"
FT DISULFID 4696..4709
FT /evidence="ECO:0000255"
FT DISULFID 4704..4722
FT /evidence="ECO:0000255"
FT DISULFID 4716..4733
FT /evidence="ECO:0000255"
FT DISULFID 4919..4938
FT /evidence="ECO:0000255"
FT DISULFID 4932..4949
FT /evidence="ECO:0000255"
FT DISULFID 5111..5127
FT /evidence="ECO:0000255"
FT DISULFID 5122..5140
FT /evidence="ECO:0000255"
FT NON_TER 1
FT /evidence="ECO:0000305"
FT NON_TER 5145
FT /evidence="ECO:0000305"
SQ SEQUENCE 5145 AA; 570249 MW; 9DD7A2727AB78AB7 CRC64;
QVPATTGSNG KCLSFWYHMY GADINTLSVY VRTGSHDTLL WSKSGTRGDK WIKALVSVTS
RSPFKIVMAA SVGRSYQGDI ALDDISMSSG ACKVSSTTCT FEESHMCGYT QDTKIDNFDW
RRGSGASITP NTGPSADHTL GSPAGFYMYI DSSSQRKGYF ARLLSPPMQR TRAKCLQFWY
HMYGSTVGSL SVYKLVTPTR GPRIWRMSGN LGDEWLVAQV SVWSPLRSYN IAFQARVGNG
GNGDIAIDDV VVFNGRCASP GNCDFERGTC TWRNTRKQDD FDWLQGKGNT LSITTGPSTD
HTTNSANGTY MFIEASSPRR LNDKARFTSQ QFSPVSVRGR CLKFWYHMLG ADIGTLNVIQ
KTGPGNRSEI LLWTLSGQQG NTWLNARVSL SKSPNTNYWI VFEGVRGNGY RGDIAIDDIQ
FTNADCRILP AKARPSKPTL PPPTTRFTLP PTIPPSLYNC DFENGFCNYT QEHITDVFNW
TRRQGGTSSG GTGPVRDHTK QQGVVVGPNG PGSLQQLRTG RCVHVFLGGF RKPPAGRSVV
YYNGCGQGRL EFQLTSDGYM KFTKFNMCWR RRGGPGSNAD DVVLADSCTE KWRFTSAKSI
QHIGTAKCVA PHLGSAVNDR KLVLSSSCDQ RNQIFRWQPT LGWYIYIEAS WPRQPNDTAR
IHSPIITSAP SQQRCLSFWY HMYGRHIASL NVYTKVGNTF NGPVWSKSGT QGNKWWNGKV
PVSNLNAYQI VFEGVRGSSY QGDIALDDIE LLNSACPATM NCDFESPLSQ LKICGWTQRS
DDNFDWRLGR GATSSINTGP SNDHTLGNQK GHYLFIETSI VRQGSKAWLQ GPQISPQSGK
CFQFWYHMYG SSIGQLNVYI LRSQSVPSSP VWSRQRNQGN SWYIAQISIT QAGYLLFEGV
RGASFTGDIA IDDFKLMDGA CNQPAYCDFE KDNWCTWTNS DKEDDFDWLL GSGSTPSVYT
GPSNDHTTGL GIGKYMFIET SSPRKSGDKA RFYSERLSPT SLRGRCVKFW YHMYGSSIGT
LKVFVKTGAG NRSESLVWSL SGNQRNRWNF GQVTIASYRS AYQIVFEGIR GNSYRGDIAI
DDITYTVGSC VTLPRGAVPT TPPTTVRPTT SPTVPPKGAL DCDFERGFCS WVQDSSDKFN
WTRQSRGTAS SNTGPSADHT LKNATGYYAY IEASFPRRAN DTARLISPLI PANSRPGMCI
SFWYHMYGPH IDTLNVYTKV GSSLGSAIWK KTGNQGNKWR YGQVFVRMVL NFQIVFEGVR
GRSYQGDIAI DDVTVRNGFC SPLKQCTFED AGMCGWRNEK SAGVDDFDWT RQSGATSSSG
TGPTFDHTLG TARGFYMYIE TSFPRKQGDK AQLLSPSYPS TSGKCLRFWY HMYGNHIGTL
NIRIKQMVLG RPTYFLQWSR SGDHGNNWRV AQVTIRSGSQ FQVVFEGIRG SGYQGDIAID
DVELKDNVCP PPGDCNFETG TCNWVNVQNT DNFDWLRGRG STPSSFTGPS VDHTTNSSSG
YYMFIETSSP RRNRDKARFE SEEFQPTGSS GRCLKFWYHM YGSSVRGLNV WMSSNGSTGQ
IWTLSGNQRQ DKWFYAQAPV RSANVYQVIF EGVRGLSYAG DIAIDDVQFI VGNCPVLPSK
AKPLNPWTPR PVPTVAPTNS TTPAPSIYDC TFEQSMCTWT QALDDSFNWT RTKGRTPSRF
TGPVSDHTTG GSAGYYVYIE TSSPRKANET ARIESVTIPA TQQKCLQFWY HMYGQTIGTL
NVYTRRSSWS LNKVWSKTGN DTNIWNVAQV TIRSPFAYQI VFEGVKGRSY TGDIAIDDVK
IMSGSCPAPG DCSFEKGFCT WANTRQVDTF DWIIGGGTTS SFGTGPSGDH TTGSGQYVFI
ETSAPRQHGD NAYLLSQPFD PAPSGRCLKF WHHMRGASIG TLNVYLHTGN FSAMQLLWQR
NGNKGSTWMI GQTPITSSVK YQVVFEGIRG NSFTGDIALD DISFTVGAAN CIQRPYDSLP
PGVTTSAPTL STSSSVAPTT IGNIGNDCNF DVGICKWTFA SYGQFNWTRH QGSTASSGTG
PKYDHTRGNS GQGYYMYIET SVPRRPNDTA GLVSPKVQKV GSFACVIFWY HMFGPHINQL
NVYFKDGSKA KTLMWQKIGS QADEWRQGLL QLSPSQGSYQ VIFEGVRGTS YQGDISLDDI
SFQNNKCPSS TDCTFEYFLG SISNTCGWTQ DGSDDFDWTR TSGGTPSHAT GPSADHTYGT
SQGYYMHIET SYPRRRGDKA RLISPVYRPV RGGQCFQFWY HMYGSDIDRL NVYIKTGSNI
SIPVWSRSGN RGDLWKISQV PVTTTVNFNI VIEGIAGRSF RGDIAIDDLK LIKSPCPLPG
DCDFESGMCT YDNTQAEDQF DWLRNAGATP SWRTGPSVDH TLGTGFGHYM YIETSSPRRQ
GDKARLMSED FNPTTSSGRC VRFWYHLYGN AIGTLRVLVK TGPGNQSETA IWELSGNFGN
QWYSAQAPVS SAKVYQVVFE GVRGRGVSGD IAIDDITFAT TRCSVVPSLA VPPTPPPTTP
PPVINNCTFE GGFCSWKNLR GDNFDWTRSR GATSSWRTGP TTDHTLGTRA GYYVYIETSF
PRRSKDKAWL QSGLIQPTTV TNGRCLKFWY HMWGTHVDTL NVYRKVGSSP NVRIWFRRGT
QGNKWRFAQV NLLSNQPFYV IFEGVRGLSY QGDIALDDLD IADGPCPPLT VCDFETDMCK
WTNIAIGDQF DWKRDSGGTP SAGTGPSRDH TTGTRNGMYM YIETSLPRRQ GDKAYFISPR
YDAAPNGKCF KFWYHMYGRH IGKLNIYVKA GPALGAMVWN ETGNQGNFWL HGKAPVKIST
QFQIVIEGIR GASYAGDIAL DDFSLDDSPC PPEGSCDFEE KSFCSWLNVP NGNKSLGLDD
FDWTLGSGST PSWQTGPSTD HTTGSSLGTY AFIETSNPRR AGHIARIRSK TFSATNGKCM
SWWLHMYGRS VGSLNVYIKK GGSPESLLWN TKGNQGNVWK KTEVTITSKS DFQIIFEGVS
GAGFQGDIAI DDIDFADKYC VGLCSSVNPQ QRVDCSGGLG ISKTTCVNLR RCCWDDSVPN
VPVCFYHPSA CASVIPANRR TCGFSGISSS QCRTRGCCWD NSLSNVPWCF HGPARPTDFP
TQPPPPTTLP PSKWDCTFES GFCNWNNSQE DDFNWSRQSG GSPSIGTGPT SDHTTGSLRG
YYVYIETSYG SANDTAVLES AMVPATIRKP SGMICLQFWY HMRGQHVDTL NVFVKPGNQL
PSSPTWTKSG TQGTQWRLGQ VAVSSRAPFQ FVFQGIRGKG YQGDIALDDI RVLDGTCPPS
RECDFESPNL CNFTQDTGDI FDWSRGSGNT ISVGTGPSYD HTYKTASGYY MYIETSAPRR
TGDYARIESI SYDQTVGNGR CLVFWHHMYG GGIGRLNVYI KRGNSLGTPV WRKNGNHGNK
WWRGMVTVRS PNQKWKVVFE GIRGRGGRGD IAIDDIIVKD QPCPPPGSCD FESGWCAYQN
DLTGDDFDWE RNTGHTSSIG TGPSVDHTTG SPQGHYVYIE SSYPRTKGDV ARLTSDLFEV
SKGYAWCLSF WYHMYGNSVG SLSVKITIYP FRKDKPYTRL LWTQQLNHGD VWLTDTVQIN
SPDDFEIVFE AVVGSSYDAD IAIDDIVVTA GFCPSPKPTV APNPCAVRCK SNNKCVSSTQ
LCDFVNDCGR GDNSDEKNCG ACTFEQDLCG WNDTSKGAFK WNKDRGGTPS SNTGPTIDHT
LGTALGYYMY VEASQGRIRD MAQLESPWLK QSASTCVVSF WYHMYGRGIG TLYGYIKVGL
TYTRLFQQSG NKGNNWLQGK LYVGRRFAPF KIIFEAERSY NVFGDVAVDD VSFVNCTLPP
IVSSCGQQHR CIRGSCIDRG RVCDYTDDCG DNSDEQNCYN FKYRCSFEKS LCQWTQLKDE
EFDWTRNQGV TASYNTGPMF DHTLGTAAGY YLYAEASYPR KKGDKARLAS GFITTPGDDS
CKLRLYFHMF GSGIGSLNVY TRPCNGCAET LVYTRSGNLG NFWERAEIAL MSRVPFQVII
ESVRGVSYLG DIAIDDLSMT SSCQSYRGPL PTAPPPTTAI PTPPPCPRFQ FKCSNGLCID
TWNVCNYRDD CGDGSDEVNC GSCSFEPGLC GYQDVSLTLY QWSRNRGTTV VPRTGPSVDH
TCGNASCFYA YVHSGAGSFF DDAILQSRNM TKTGPGCVVS FYYHMYSRLS AGFTGTLYLR
LKYKGTTSNL FEVYGNNGDK WKRAEVGLGS LDAGFSIQFV ASKFVTAADI AVDDVTFQGC
ALPPIRSCIS GEYRCTRGSC VLPSQLCDFS DDCGDMSDEN PSTCASYKER CNFEQDLCSW
TQDTDDDFDW TKDSGGTPSS WTGPGRDHTK GSSKGFYMYI ETSSPRKSNE SARMSSMTFR
PSSRNDSCYM RFWYHMFGKD VDTLSIKLRI SMIGPLIPLW NRTGEQGDMW RRAEIHLASN
VNFQVVIEGL SGPGFQGDIA IDDVSFTPNC RPDSTASIST TIPTGPPIPG CQPGKFKCAN
GGNCISVSKV CNFYSDCSGG SDEMNCPATC NFQNSFCKWQ NAKSVDHYDW VRNKGQTPSR
FTGPSVDHTT NSSAGYYIYT EVSNRTGFFA DAHLVSPLFR QAGKNCQFKF WYHMFGPNIG
FLQVFYRRNS RDQQLFSVFG NKGNKWNQGT VDIPKCANDF RIVIMAKHYS GGALGDIAVD
DVSFEHCAES PPSQTCSGLS VFRCQSGHCI AMSGKCDFEP DCCDGSEETN IVCAKYNRCN
FEAGLCDWTQ LANDTFNWRM QSGRTGSHRT GPSLDHTTRS RNGRYMYIEA SSPRKPGDSA
ILGSAVFKPT GSCKLRFFYH MYGSHIGHLN VSIRTSTNGP STVLWTKSGD QGDKWTRATV
SISVSKNFQV LIEGVVGSSY RGDIAIDDIS FTPDCVVGGT IPGLPPPPPT PTQPSCFNCR
DGSACVNISK TCDFHNDCTD KSDEDADLCG WPCDFQRGTC SWTNSNRDNF DWTRHKGCTA
SVSTGPCVDA DNRTSGYYMY IETSTGLIGN KAVLVSPRYQ QAYSTAQLSF WYHMYGRTIG
RLSVYLNDGI NRTRMWTLYG NQGDQWYQTF ISLGRRRTPF TIEFEALRGS SWSGDIAIDS
ISMNNYTLTY CSGQLPPTKW RCRNGACVDA NALCDFSDDC GDNSD
