MLRP2_ACRMI
ID MLRP2_ACRMI Reviewed; 7311 AA.
AC B3EWZ6;
DT 09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT 09-JUL-2014, sequence version 1.
DT 23-FEB-2022, entry version 20.
DE RecName: Full=MAM and LDL-receptor class A domain-containing protein 2;
DE AltName: Full=Skeletal organic matrix MAM and LDL-receptor 2 {ECO:0000303|PubMed:23765379};
DE Short=SOM MAM and LDL-receptor 2 {ECO:0000303|PubMed:23765379};
DE Flags: Fragment;
OS Acropora millepora (Staghorn coral) (Heteropora millepora).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia;
OC Astrocoeniina; Acroporidae; Acropora.
OX NCBI_TaxID=45264;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=22490231; DOI=10.1111/j.1365-294x.2012.05554.x;
RA Moya A., Huisman L., Ball E.E., Hayward D.C., Grasso L.C., Chua C.M.,
RA Woo H.N., Gattuso J.P., Foret S., Miller D.J.;
RT "Whole transcriptome analysis of the coral Acropora millepora reveals
RT complex responses to CO(2)-driven acidification during the initiation of
RT calcification.";
RL Mol. Ecol. 21:2440-2454(2012).
RN [2] {ECO:0000305}
RP PROTEIN SEQUENCE OF 390-413; 429-444; 495-509; 660-674; 781-804; 1537-1566;
RP 1689-1699; 2070-2080; 2222-2233; 2395-2416; 2698-2709; 2906-2929;
RP 3006-3027; 3185-3193; 3526-3534 AND 3762-3774, TISSUE SPECIFICITY, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=23765379; DOI=10.1093/molbev/mst109;
RA Ramos-Silva P., Kaandorp J., Huisman L., Marie B., Zanella-Cleon I.,
RA Guichard N., Miller D.J., Marin F.;
RT "The skeletal proteome of the coral Acropora millepora: the evolution of
RT calcification by co-option and domain shuffling.";
RL Mol. Biol. Evol. 30:2099-2112(2013).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:23765379}.
CC -!- TISSUE SPECIFICITY: Component of the acid-insoluble and acid-soluble
CC organic matrix of the aragonitic skeleton (at protein level).
CC {ECO:0000269|PubMed:23765379}.
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DR EMBL; JR994474; -; NOT_ANNOTATED_CDS; mRNA.
DR SMR; B3EWZ6; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR CDD; cd00112; LDLa; 15.
DR CDD; cd06263; MAM; 37.
DR CDD; cd00111; Trefoil; 2.
DR Gene3D; 4.10.110.10; -; 2.
DR Gene3D; 4.10.400.10; -; 15.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR017957; P_trefoil_CS.
DR InterPro; IPR000519; P_trefoil_dom.
DR InterPro; IPR044913; P_trefoil_dom_sf.
DR Pfam; PF00057; Ldl_recept_a; 8.
DR Pfam; PF00629; MAM; 37.
DR Pfam; PF00088; Trefoil; 2.
DR PRINTS; PR00261; LDLRECEPTOR.
DR PRINTS; PR00020; MAMDOMAIN.
DR SMART; SM00192; LDLa; 15.
DR SMART; SM00137; MAM; 37.
DR SMART; SM00018; PD; 2.
DR SUPFAM; SSF49899; SSF49899; 37.
DR SUPFAM; SSF57424; SSF57424; 14.
DR SUPFAM; SSF57492; SSF57492; 2.
DR PROSITE; PS01209; LDLRA_1; 12.
DR PROSITE; PS50068; LDLRA_2; 14.
DR PROSITE; PS00740; MAM_1; 1.
DR PROSITE; PS50060; MAM_2; 37.
DR PROSITE; PS00025; P_TREFOIL_1; 1.
DR PROSITE; PS51448; P_TREFOIL_2; 2.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Repeat; Secreted.
FT CHAIN <1..>7311
FT /note="MAM and LDL-receptor class A domain-containing
FT protein 2"
FT /id="PRO_0000429551"
FT DOMAIN 4..171
FT /note="MAM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 199..361
FT /note="MAM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 363..530
FT /note="MAM 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 532..695
FT /note="MAM 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 727..887
FT /note="MAM 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 889..1050
FT /note="MAM 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 1052..1220
FT /note="MAM 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 1228..1392
FT /note="MAM 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 1394..1557
FT /note="MAM 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 1559..1722
FT /note="MAM 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 1755..1918
FT /note="MAM 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 1920..2087
FT /note="MAM 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 2089..2254
FT /note="MAM 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 2274..2437
FT /note="MAM 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 2439..2601
FT /note="MAM 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 2603..2771
FT /note="MAM 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 2771..2817
FT /note="P-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DOMAIN 2818..2862
FT /note="P-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT DOMAIN 2883..3048
FT /note="MAM 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 3050..3214
FT /note="MAM 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 3216..3384
FT /note="MAM 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 3429..3587
FT /note="MAM 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 3593..3628
FT /note="LDL-receptor class A 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3632..3794
FT /note="MAM 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 3814..3850
FT /note="LDL-receptor class A 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 3850..4011
FT /note="MAM 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 4016..4054
FT /note="LDL-receptor class A 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 4058..4221
FT /note="MAM 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 4239..4276
FT /note="LDL-receptor class A 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 4277..4438
FT /note="MAM 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 4444..4483
FT /note="LDL-receptor class A 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 4486..4646
FT /note="MAM 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 4660..4699
FT /note="LDL-receptor class A 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 4700..4862
FT /note="MAM 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 4859..4899
FT /note="LDL-receptor class A 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 4903..5063
FT /note="MAM 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 5085..5122
FT /note="LDL-receptor class A 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 5123..5281
FT /note="MAM 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 5287..5322
FT /note="LDL-receptor class A 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 5326..5489
FT /note="MAM 29"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 5513..5552
FT /note="LDL-receptor class A 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 5554..5719
FT /note="MAM 30"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 5725..5763
FT /note="LDL-receptor class A 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 5768..5935
FT /note="MAM 31"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 5957..5993
FT /note="LDL-receptor class A 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 5994..6156
FT /note="MAM 32"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 6161..6200
FT /note="LDL-receptor class A 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 6204..6365
FT /note="MAM 33"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 6377..6414
FT /note="LDL-receptor class A 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DOMAIN 6430..6590
FT /note="MAM 34"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 6606..6779
FT /note="MAM 35"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 6808..6965
FT /note="MAM 36"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT DOMAIN 7173..>7311
FT /note="MAM 37"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT REGION 2461..2481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6014..6034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 2773..2802
FT /evidence="ECO:0000255"
FT DISULFID 2784..2801
FT /evidence="ECO:0000255"
FT DISULFID 2795..2813
FT /evidence="ECO:0000255"
FT DISULFID 2820..2847
FT /evidence="ECO:0000255"
FT DISULFID 2831..2846
FT /evidence="ECO:0000255"
FT DISULFID 2841..2858
FT /evidence="ECO:0000255"
FT DISULFID 3594..3605
FT /evidence="ECO:0000255"
FT DISULFID 3600..3618
FT /evidence="ECO:0000255"
FT DISULFID 3612..3627
FT /evidence="ECO:0000255"
FT DISULFID 3815..3827
FT /evidence="ECO:0000255"
FT DISULFID 3822..3840
FT /evidence="ECO:0000255"
FT DISULFID 3834..3849
FT /evidence="ECO:0000255"
FT DISULFID 4017..4029
FT /evidence="ECO:0000255"
FT DISULFID 4024..4042
FT /evidence="ECO:0000255"
FT DISULFID 4036..4053
FT /evidence="ECO:0000255"
FT DISULFID 4240..4253
FT /evidence="ECO:0000255"
FT DISULFID 4247..4266
FT /evidence="ECO:0000255"
FT DISULFID 4260..4275
FT /evidence="ECO:0000255"
FT DISULFID 4445..4458
FT /evidence="ECO:0000255"
FT DISULFID 4453..4471
FT /evidence="ECO:0000255"
FT DISULFID 4465..4482
FT /evidence="ECO:0000255"
FT DISULFID 4668..4687
FT /evidence="ECO:0000255"
FT DISULFID 4681..4698
FT /evidence="ECO:0000255"
FT DISULFID 4860..4876
FT /evidence="ECO:0000255"
FT DISULFID 4871..4889
FT /evidence="ECO:0000255"
FT DISULFID 4883..4898
FT /evidence="ECO:0000255"
FT DISULFID 5086..5099
FT /evidence="ECO:0000255"
FT DISULFID 5093..5112
FT /evidence="ECO:0000255"
FT DISULFID 5106..5121
FT /evidence="ECO:0000255"
FT DISULFID 5288..5299
FT /evidence="ECO:0000255"
FT DISULFID 5294..5312
FT /evidence="ECO:0000255"
FT DISULFID 5306..5321
FT /evidence="ECO:0000255"
FT DISULFID 5514..5529
FT /evidence="ECO:0000255"
FT DISULFID 5521..5542
FT /evidence="ECO:0000255"
FT DISULFID 5536..5551
FT /evidence="ECO:0000255"
FT DISULFID 5726..5738
FT /evidence="ECO:0000255"
FT DISULFID 5733..5751
FT /evidence="ECO:0000255"
FT DISULFID 5745..5762
FT /evidence="ECO:0000255"
FT DISULFID 5958..5970
FT /evidence="ECO:0000255"
FT DISULFID 5965..5983
FT /evidence="ECO:0000255"
FT DISULFID 5977..5992
FT /evidence="ECO:0000255"
FT DISULFID 6162..6175
FT /evidence="ECO:0000255"
FT DISULFID 6169..6188
FT /evidence="ECO:0000255"
FT DISULFID 6182..6199
FT /evidence="ECO:0000255"
FT DISULFID 6378..6391
FT /evidence="ECO:0000255"
FT DISULFID 6385..6404
FT /evidence="ECO:0000255"
FT DISULFID 6398..6413
FT /evidence="ECO:0000255"
FT NON_TER 1
FT /evidence="ECO:0000305"
FT NON_TER 7311
FT /evidence="ECO:0000305"
SQ SEQUENCE 7311 AA; 810540 MW; CF50CDFD66E6F1C5 CRC64;
NQPAYCDFEK DNWCTWTNSD KEDDFDWLLG SGSTPSVYTG PSNDHTTGLG IGKYMFIETS
SPRKSGDKAR FYSERLSPTS LRGRCVKFWY HMYGSSIGTL KVFVKTGAGN RSESLVWSLS
GNQRNRWNFG QVTIASYRSA YQIVFEGIRG NSYRGDIAID DITYTVGSCV TLPRGAVPTT
PPTTVRPTTS PTVPPKGALD CDFERGFCSW VQDSSDKFNW TRQSRGTASS NTGPSADHTL
KNATGYYAYI EASFPRRAND TARLISPLIP ANSRPGMCIS FWYHMYGPHI DTLNVYTKVG
SSLGSAIWKK TGNQGNKWRY GQVFVRMVLN FQIVFEGVRG RSYQGDIAID DVTVRNGFCS
PLKQCTFEDA GMCGWRNEKS AGVDDFDWTR QSGATSSSGT GPTFDHTLGT ARGFYMYIET
SFPRKQGDKA QLLSPSYPST SGKCLRFWYH MYGNHIGTLN IRIKQMVLGR PTYFLQWSRS
GDHGNNWRVA QVTIRSGSQF QVVFEGIRGS GYQGDIAIDD VELKDNVCPP PGDCNFETGT
CNWVNVQNTD NFDWLRGRGS TPSSFTGPSV DHTTNSSSGY YMFIETSSPR RIGDKARFES
EEFQPTGSSG RCLKFWYHMY GSSVRGLNVW MSSNGSTGQI WTLSGNQRQD KWFYAQAPVR
SANVYQVIFE GVRGLSYAGD IAIDDVQFIV GNCPVLPSKA KPLNPWTPRP VPTVAPTNST
TPAPSIYDCT FEQSMCTWTQ ALDDSFNWTR TKGRTPSRFT GPVSDHTTGG SAGYYVYIET
SSPRKANETA RIESVTIPAT QQKCLQFWYH MYGPHVDTLN VYTKINNQLG VPVWTLNGTQ
GNKWRHAVVS LTVSSKFKVV FEGRRGVSWA GDIALDDISF QDGQCPVQMQ CSFENPNLCG
WSNVQGDNFD WTRSNGYTSS SGTGPSVDHT SGTSNGYYMY IETSSPRSRG HKAWFVSSPF
KATNGRCLQF WYHMYGATIG ALNVLLLQNR TRSAPIWNLS GNQGNLWRMA QVTLKSPTDF
KVIFEGVTGT SYTGDIAIDD VEIMDGACPL PGDCTFEKGT CTWVNSLNVV DDEFDWTRGS
GGTPSSFTGP STDHTTGTKN GNYMFIETSF PRKRGDRARL ESEVFPPTTS TGRCMSFWYH
MMGGHIGTLN VYMKIYGQSE TKLWSMTLDQ GNNWNSARVP IVSGNRYYQI ILEGVRGSSY
QGDIAIDDIS FVATARRCRL SPSNAVPFDC NFELGTCSWT QSFRDQFHWT RHQGSTGSFL
TGPSIDHTTA TNKGWYIYIE TSGPRRPNDT ARIVSPTIAG NGTVKVIRCV SFWYHMYGPH
VDELRLYKKE GFSLGKPQWV RQGDQGNKWI KGEYTVEHTN GIQIVFEGVR GVSYRGDIAL
DDISLKDGSC PSSGMCSFEA PDICGYTQDH DTDQFDWSRS NGPTASFSTG PAADHTYGTL
FGHFMYTEVS PSSITQGSKA RLLSPRYPAT RGSCLQFWYH MYGQTIGTLN VYTRRSSWSL
NKVWSKTGND TNIWNVAQVT IRSPFAYQIV FEGVKGRSYT GDIAIDDVKI MSGSCPAPGD
CSFEKGFCTW ANTRQVDTFD WIIGGGTTSS FGTGPSGDHT TGSGQYVFIE TSAPRQHGDN
AYLLSQPFDP APSGRCLKFW HHMRGASIGT LNVYLHTGNF SAMQLLWQRN GNKGSTWMIG
QTPITSSVKY QVVFEGIRGN SFTGDIALDD ISFTVGAANC IQRPYDSLPP GVTTSAPTLS
TSSSVAPTTI GNIGNDCNFD VGICKWTFAS YGQFNWTRHQ GSTASSGTGP KYDHTRGNSG
QGYYMYIETS VPRRPNDTAG LVSPKVQKVG SFACVIFWYH MFGPHINQLN VYFKDGSKAK
TLMWQKIGSQ ADEWRQGLLQ LSPSQGSYQV IFEGVRGTSY QGDISLDDIS FQNNKCPSST
DCTFEYFLGS ISNTCGWTQD GSDDFDWTRT SGGTPSHATG PSADHTYGTS QGYYMHIETS
YPRRRGDKAR LISPVYRPVR GGQCFQFWYH MYGSDIDRLN VYIKTGSNIS IPVWSRSGNR
GDLWKISQVP VTTTVNFNIV IEGIAGRSFR GDIAIDDLKL IKSPCPLPGD CDFESGMCTY
DNTQAEDQFD WLRNAGATPS WRTGPSVDHT LGTGFGHYMY IETSSPRRQG DKARLMSEDF
NPTTSSGRCV RFWYHLYGNA IGTLRVLVKT GPGNQSETAI WELSGNFGNQ WYSAQAPVSS
AKVYQVVFEG VRGRGVSGDI AIDDITFATT RCSVVPSLAV PPTPPPTTPP PVINNCTFEG
GFCSWKNLRG DNFDWTRSRG ATSSWRTGPT TDHTLGTRAG YYVYIETSFP RRSKDKAWLQ
SGLIQPTTVT NGRCLKFWYH MWGTHVDTLN VYRKVGSSPN VRIWFRRGTQ GNKWRFAQVN
LLSNQPFYVI FEGVRGLSYQ GDIALDDLDI ADGPCPPLTV CDFETDMCKW TNIAIGDQFD
WKRDSGGTPS AGTGPSRDHT TGTRNGMYMY IETSLPRRQG DKAYFISPRY DAAPNGKCFK
FWYHMYGRHI GKLNIYVKAG PALGAMVWNE TGNQGNFWLH GKAPVKISTQ FQIVIEGIRG
ASYAGDIALD DFSLDDSPCP PEGSCDFEEK SFCSWLNVPN GNKSLGLDDF DWTLGSGSTP
SWQTGPSTDH TTGSSLGTYA FIETSNPRRA GHIARIRSKT FSATNGKCMS WWFHMYGRSV
GSLNVYIKKG GSPESLLWNT KGNQGNVWKK TEVTITSKSD FQIIFEGVSG AGFQGDIAID
DIDFADKYCV GLCSSVNPQQ RVDCSGGLGI SKTTCVNLRR CCWDDSVPNV PVCFYHPSAC
ASVIPANRRT CGFSGISSSQ CRTRGCCWDN SLSNVPWCFH GPARPTDFPT QPPPPTTLPP
SKWDCTFESG FCNWNNSQED DFNWSRQSGG SPSIGTGPTS DHTTGSLRGY YVYIETSYGS
ANDTAVLESA MVPATIRKPS GMICLQFWYH MRGQHVDTLN VFVKPGNQLP SSPTWTKSGT
QGTQWRLGQV AVSSRAPFQF VFQGIRGKGY QGDIALDDIR VLDGTCPPSR ECDFESPNLC
NFTQDTGDIF DWSRGSGNTI SVGTGPSYDH TYKTASGYYM YIETSAPRRT GDYARIESIS
YDQTVGNGRC LVFWHHMYGG GIGRLNVYIK RGNSLGTPVW RKNGNHGNKW WRGMVTVRSP
NQKWKVVFEG IRGRGGRGDI AIDDIIVKDQ PCPPPGSCDF ESGWCAYQND LTGDDFDWER
NTGHTSSIGT GPSVDHTTGS PQGHYVYIES SYPRTKGDVA RLTSDLFEVS KGYAWCLSFW
YHMYGNSVGS LSVKITIYPF RKDKPYTRLL WTQQLNHGDV WLTDTVQINS PDDFEIVFEA
VVGSSYDADI AIDDIVVTAG FCPSPKPTVA PNPCAVRCKS NNKCVSSTQL CDFVNDCGRG
DNSDEKNCGA CTFEQDLCGW NDTSKGAFKW NKDRGGTPSS NTGPTIDHTL GTALGYYMYV
EASQGRIRDM AQLESPWLKQ SASTCVVSFW YHMYGRGIGR LYGYIKVGLT YTRLFQQSGN
KGNNWLQGKL YVGRRFAPFK IIFEAERSYN VFGDVAVDDV SFVNCTLPPI VSSCGQQHRC
IRGSCIDRGR VCDYTDDCGD NSDEQNCYNF KYRCSFEKSL CQWTQLKDEE FDWTRNQGVT
ASYNTGPMFD HTLGTAAGYY LYAEASYPRK KGDKARLASG FITTPGDDSC KLRLYFHMFG
SGIGSLNVYT RPCNGCAETL VYTRSGNLGN FWERAEVALM SRVPFQVIIE SVRGVSYLGD
IAIDDLSMTS SCQSYRGPLP TAPPPTTAIP TPPPCPRFQF KCSNGLCIDT WNVCNYRDDC
GDGSDEVNCG SCSFEPGLCG YQDVSLTLYQ WSRNRGTTVV PRTGPSVDHT CGNASCFYAY
VHSGAGSFFD DAILQSRNMT KTGPGCVVSF YYHMYSRLSA GFTGTLYLRL KYKGTTSNLF
EVYGNNGDKW KRAEVGLGSL DAGFSIQFVA SKFVTAADIA VDDVTFQGCA LPPIRSCISG
EYRCTRGSCV LPSQLCDFSD DCGDMSDENP STCASYKERC NFEQDLCSWT QDTDDDFDWT
KDSGGTPSSW TGPGRDHTKG SSKGFYMYIE TSSPRKSNES ARMSSMTFRP SSRNDSCYMR
FWYHMFGKDV DTLSIKLRIS MIGPLIPLWN RTGEQGDMWR RAEIHLASNV NFQVVIEGLS
GPGFQGDIAI DDVSFTPNCR PDSTASISTT IPTGPPIPGC QPGKFKCANG GNCISVSKVC
NFYSDCSGGS DEMNCPATCN FQNSFCKWQN AKSVDHYDWV RNKGQTPSRF TGPSVDHTTN
SSAGYYIYTE VSNRTGFFAD AHLVSPLFRQ AGKNCQFKFW YHMFGPNIGF LQVFYRRNSR
DQQLFSVFGN KGNKWNQGTV DIPKCANDFR IVIMAKHYSG GALGDIAVDD VSFEHCAESP
PSQTCSGLSV FRCQSGHCIA MSGKCDFEPD CCDGSEETNI VCAKYNRCNF EAGLCDWTQL
ANDTFNWRMQ SGRTGSHRTG PSLDHTTRSR NGRYMYIEAS SPRKPGDSAI LGSAVFKPTG
SCKLRFFYHM YGSHIGHLNV SIRTSTNGPS TVLWTKSGDQ GDKWTRATVS ISVSKNFQVL
IEGVVGSSYR GDIAIDDISF TPDCVVGGTI PGLPPPPPTP TQPSCFNCRD GSACVNISKT
CDFHNDCTDK SDEDADLCGW PCDFQRGTCS WTNSNRDNFD WTRHKGCTAS VSTGPCVDAD
NRTSGYYMYI ETSTGLIGNK AVLVSPRYQQ AYSTAQLSFW YHMYGRTIGR LSVYLNDGIN
RTRMWTLYGN QGDQWYQTFI SLGRRRTPFT IEFEALRGSS WSGDIAIDSI SMNNYTLTYC
SGQLPPTKWR CRNGACVDAN ALCDFSDDCG DNSDEQSCSN YFSRCTFENG LCDWFQGSGD
EIDWIRNKGP TPSFSTGPSR DHTLGTVEGY YLYMEATGQK FGDRARLASN NLMGKCNLRM
FYHMHGIHVN SLAVYMRTKL NGPLRVVANM SGSVGDNWIR SEVNVTNGDQ PFQIVIEGVR
GRGYRGDIAI DDLSIAMKPS CQQFFGSLPW LGSTVKPITT VAPNNCVLPQ VPCVSDGKCV
SPSQVCDFNL DCADASDERS CPHMCTFESD QCGWVNTVKD NFDWSRKRGR TPSFGTGPSV
DHTTGTNQGY YMYIETSYGR IGDRARLISP QFKKSHSNCK MVFWYHMYGS SIGSLSVYLN
VSSNTKLWWR KYGYQGNQWY RGVVGIGKRS NAFQIIFLGI RGRSYSGDIA IDDIKFVDCA
LPPVARSCPS QFTCARNSCV SNDYVCDFND DCGDGSDETL CGAYTTRCDF SRGSCDWTQS
NEDDFNWLRR KGATSSFNTG PPSDHTSQTG YYMYIETSWP RRYGDKAWLV SRNFQEMTPG
SESCKLRFFY HMFGDSAESL NVYIRTYRNG SALQRVWGVK GSRGAIWNRA VITLSSRKNF
QVLIEGIRGD SYTGDIGIDD VSFTTGCKQF SGNLPVAPPI SPTSNPATTK PHQCTTAEFN
CFNQGSGACI PSTQVCNFQP NCNDGVDEQN CAKTKCSFDG GDFCNWYVNN PSRTRRALAY
TWLAQQGATG SSGTGPTKDH TTGTLSGWYI YAESSGGSND DRAPLTTPLI GQTGPECTLL
FWYHMFGVSV GTLSVKLSFL DGTQSVMWSK SGSQGNRWRQ SKLMIGSRQL FKVTFEARRS
YGYKGDIALD DIEFLNCVPL DLTKKCTADE FQCARGGCIP KTSVCDFKAD CMVGDVSDES
SCSAYRSGQC DFEHGLCLYS QSSDDKFDWT VKTGGTFSYN TGPTIDHTTK SKKGHYMYIE
TSWPRRNGDN ARLNSPILKS TSSNCYLRFF YHMKGNHIGN LSVFSRTGYS VGDLSGPLLN
ITGAQGDFWN RSMVKAPVSS NDFQFVIEGV RGNGYQGDIA IDDVSLTPGC QICTDCTLPG
QPTSTPFGFH TRPTGTPCSL QQYVCKNLRC VDKAQICNFK DDCGDNSDEL PCGSNCTFEG
DCYRGWRQST GSSNFHWRRR NGKTPSVGTG PTNDHTFGNQ NGYYMYIETS NGSPGDKAEL
ASYRYFASSP NCRMSLWYHM FGTGVGSLEV KLKKSDGTYE ILGNALTGSQ GNAWKKYTLN
IGANKNFEIL IVAARGINWQ GDIAIDDISF TDNCFVDLNR TCTPNEVKCR TSGHCVAEQR
VCDHVKDCND GTDEDALICS NRTASCDFDV NWCQWDNYWV DDFNWLRASA IGTPNTGPRA
DHTTGKGYFL YIDSSKPRQL FDKARLVHPN VFPSGRGVCT LRFYYNMYGS QNMGYLNVYL
VYSGYSQWTQ VWRTRGDPAN RLWVRAEIQL NSQSSFRVGF EGIVGGGDKT DIALDDISFS
AGCYKGGSPP LPTGSARCSK VQFYCKADDL CINIHWKCDG EKDCTDGADE MLCPSPTKQP
TPPPGLTHPA NCNFESGFCL WRSAFFADMN WLRNRGQTPS RQTGPDGDHT TGTGYYVYAE
ATGHYMNQFG ELLGPNMMPS STCKVYFCYL MHGKDMGTLN VYQRFPSDKK PDQTQKRKWS
QSLDFGKKWR CVYVPLPSTR QFSVVFEAIR GKGYRSDIAL DDIKFVNCAK LGPTQKPTPA
PRGTILDEDF EDCISCWMNE KNGHDQMDWV IGRGETSSLN TGPSYDHTRK TIYGRYLYID
VYSASHIQGW VHADLESRLM VVQRRCYMTF WYHMYGAGMG SLWIVAYVYD DPKNLNDWRE
VSLWYSYGNQ GNKWTSGKVN LFNHLTASKT SRVVISGIRG SDYTGDIAID DIKFHNCDFK
DDKTPCGEVF DRCNDRPIPK PTLGPASGDC TFESGLCHWN NTIVNDMPWF LRKGKTGSQY
TGPAVDHTLG TPDGYYVHIE ASWYTRGSVA ILEGPYTLPT QNCEMKFYYH MFGGDCGSLL
VYINSGDSVK LVFNKTGEQG KDWLGASVQL KSDYAFRIHI TATRGSSYKG DIAIDDISFK
GQCQFTSNAA LRYGDKLLTT GCADGGREGF FSHPSVAGCK GRWSRPESLR AKPTSGAKCG
DDIGLWGRSC SQPAELCATG WHICGSYGVR EIVNRTNGID CQEAGYGKFS AGINHCMQNN
AGGDGCKRVV TDIDYGCGKY YDSCSEPLCC GSNCQGPDIC DSGVFRAATR YSASSEHLEG
CSFISSDNAG GIMCCKDDAT TPTPAPTMPP VPGSCNFETG LCGWIVDSST ALSFGLGQGE
TVTRNTGPRY DNTKKDMTGT YLSMPAVNGK PNDIARVSHH FSNVTQSYCQ INFFYHMYGA
GMGSLRVFVE LDGGGKKKVW EKTGNQGDGW LRGAQNFSGA DQEDDCIYNN L
