MLRR1_PLAF7
ID MLRR1_PLAF7 Reviewed; 10061 AA.
AC Q8I3Z1;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 23-FEB-2022, entry version 94.
DE RecName: Full=MATH and LRR domain-containing protein PFE0570w;
GN ORFNames=PFE0570w;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2] {ECO:0000312|EMBL:CAD51479.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [3] {ECO:0000305}
RP SYNTHESIS OF 1920-1946, DEVELOPMENTAL STAGE, AND POSSIBLE CANDIDATE MALARIA
RP EPITOPE.
RX PubMed=17653272; DOI=10.1371/journal.pone.0000645;
RA Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nebie I.,
RA Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S., Heitz F.,
RA Baecker V., Druilhe P., Kajava A.V., Corradin G.;
RT "Rapid identification of malaria vaccine candidates based on alpha-helical
RT coiled coil protein motif.";
RL PLoS ONE 2:E645-E645(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed during the asexual cell-cycle on the
CC cell surface of the host erythrocytes. {ECO:0000269|PubMed:17653272}.
CC -!- BIOTECHNOLOGY: Possible candidate for an effective malaria vaccine as
CC determined by epitope response in sera. {ECO:0000269|PubMed:17653272}.
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DR EMBL; AL844504; CAD51479.1; -; Genomic_DNA.
DR RefSeq; XP_001351672.1; XM_001351636.1.
DR BioGRID; 1208256; 13.
DR IntAct; Q8I3Z1; 10.
DR STRING; 5833.PFE0570w; -.
DR PRIDE; Q8I3Z1; -.
DR EnsemblProtists; CAD51479; CAD51479; PF3D7_0511500.
DR GeneID; 812939; -.
DR KEGG; pfa:PF3D7_0511500; -.
DR VEuPathDB; PlasmoDB:PF3D7_0511500; -.
DR HOGENOM; CLU_000013_0_0_1; -.
DR InParanoid; Q8I3Z1; -.
DR OMA; LQRIFIC; -.
DR PhylomeDB; Q8I3Z1; -.
DR Proteomes; UP000001450; Chromosome 5.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR CDD; cd00121; MATH; 1.
DR CDD; cd02869; PseudoU_synth_RluA_like; 2.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF55120; SSF55120; 2.
DR PROSITE; PS50144; MATH; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Membrane; Merozoite; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..10061
FT /note="MATH and LRR domain-containing protein PFE0570w"
FT /id="PRO_0000356830"
FT TRANSMEM 3398..3418
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 1328..1458
FT /note="MATH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
FT REGION 166..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 244..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1004..1170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1651..1698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1973..1998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2155..2245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2427..2566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3120..3139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3802..3826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3847..3890
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3919..3953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4039..4074
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4155..4180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4352..4414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4919..4943
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4991..5030
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5179..5207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5716..5816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5892..6009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6123..6142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6299..6338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6722..6760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7585..7730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7744..7787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8189..8252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8293..8380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 8474..8497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9759..9779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9891..9926
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 9985..10061
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 338..366
FT /evidence="ECO:0000255"
FT COILED 431..469
FT /evidence="ECO:0000255"
FT COILED 1916..1948
FT /evidence="ECO:0000255"
FT COILED 2555..2580
FT /evidence="ECO:0000255"
FT COILED 3977..4001
FT /evidence="ECO:0000255"
FT COILED 4399..4424
FT /evidence="ECO:0000255"
FT COILED 5006..5046
FT /evidence="ECO:0000255"
FT COILED 5486..5563
FT /evidence="ECO:0000255"
FT COILED 5728..5810
FT /evidence="ECO:0000255"
FT COILED 5900..6022
FT /evidence="ECO:0000255"
FT COILED 6719..6743
FT /evidence="ECO:0000255"
FT COILED 7601..7637
FT /evidence="ECO:0000255"
FT COILED 7710..7813
FT /evidence="ECO:0000255"
FT COILED 7934..7961
FT /evidence="ECO:0000255"
FT COILED 8217..8241
FT /evidence="ECO:0000255"
FT COILED 8644..8697
FT /evidence="ECO:0000255"
FT COILED 8882..8907
FT /evidence="ECO:0000255"
FT COILED 9219..9247
FT /evidence="ECO:0000255"
FT COMPBIAS 169..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..284
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..369
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..393
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1011..1027
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1055..1133
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1134..1163
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1656..1678
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2155..2173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2194..2216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2231..2245
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2427..2443
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2450..2471
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2472..2487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2488..2531
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2532..2566
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3804..3826
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3921..3940
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4039..4066
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4157..4180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4991..5019
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5716..5814
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5908..5930
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5931..5971
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5973..6009
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7599..7682
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7704..7725
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7762..7787
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8217..8245
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8314..8363
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8476..8491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9760..9779
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 10061 AA; 1187585 MW; F13CE7E4FE86F3DD CRC64;
MDCNFFEEDG SSSMNQTNGI SKENVSEKVY SEDDKNTSCY VSYSSHSDDS YLDVEYENVH
KSRDIENHIN DNNKNMDNYN LGYCNFNDVM IDKNIECINK KELNCLKLKK NILNRSENYN
NDIVSTEYSD NHTLYKNCSG TDDKNYSNNK DDKISDDHKC DKFVDDMDNN PNNHVSNNGD
PKKCENLSPD NDTSNSIHKN NNTNINEKKN GEKKFIEGHF LSVINKFKRS LKENVIGKKI
WNNNNSDITT IEPHTLQNED SITDNNKSNK KSDNNNDKKN DDDNNNNNNN NNNNNNNNNN
NDNHVCTSNN QPNTINKQNN LPSHKINDQN GRTKITPQNV NQKEKEIKNV VKEKNNFNRE
EKDITNSDDY DENSTDESCS YNPNITSSEN SEEDCYEPSS DDKPSNNTSD HININDIRND
VPSNDNASSL NVKSAENCNK EKKKKKKKKK KELNNDNKDN TLNNETMNDI NMNNKNDNTC
FTIQESNKNC KNENFLILGN ENEMKTSRIN VPKIEIIKDE EPNRFFDNND LKNKNINDHD
NDNDDIDFIK MIKDKMKKSI YNNKDNKCIS KKSNINKIEN PVNNNNNNNN NNNNDINIFS
NLSEQNILKK ESNVCESYEG RKESNNTIHK IHCSKGKKNI MNLNNSSNTS SNFLSQHTLD
DINKKYNVLS DVNLLKLIAH CSKSKNGEFP SMDDKIIEDF INMKKNSIKN EIKKHIIYIC
AKCRLEMKLS NNPYLCFECF INEMNAHTGK TVRMANGTDF NIKDVKVINS YISKFFVEVD
KLKNKFEMDD EEIMLMFSEM RKSTLWNSEK NMCKLFFDIF KNYDIIDNNS IFSSNNKTRT
DFLKQNYDIK IEEWNQNEDE KRLINNIINN EILSPGYIKE LLKFYNFSKM KMKPKTNEQI
EEIYLKPKSK KVNHYKNIRK KKYTVHKDIC KIRTVCNSTC RINSCNYCSC IFDSIKCRFI
LISKMKNTKK LVYEKRINNS TISVEKMHEV KEIKIEQKDI FIHDDQKNSK DVPPSYNFGN
SPIPNEEKPN VNKEGNIRIR NAINIFNKNK NNNNNNNDKN DKNDKNDKND KNDKNDGKNN
NKGNDKNNNR GNDKNNDKKN NRDNDKNNDK NNDKKNNKDN NNKKKKNGKE QNEDSTESDD
ESSVIDDNYI DDDSCDCDSE SDSIDYDTSF NSESNYDDNS FIDMSDNDNT LNYIKNYETT
YNALDIFMKD IDKINKNREE LNNILPIKKS LDNYVLPNII TQKVLPPVIL PLNKQMTNLF
YELRYRDFFH IEKIDYYKLF TMQKGISNIY MKKFLMNNED MSFNSITNGI ETYNYTNENI
VINHKNNNGK IELYIPNFWR SIKSVNEIKS LTGNYYDFYY KVLVHPRGNS NDDNYMSAYL
EVIKQDFYPS EWVFPNVHFQ LTVHNFKNRK NSISSASCWS FTNNSLSRGW QKMISHSKIN
KVSGFLDESG GLLIKGKVEI TFKQLWSKSV QYSPKYIWSY MPEKLYAHFQ QEDPLLNFLF
KKSYFKNILH KNEKHNNYNS SINDLKKNDN NKSNNYYINK NSNCDKNKNI DRMKKMSYYN
MNYLYNRYTL DIYNYSLYWS PQLVKSYFGN VDHKKKCNKS LANNTNNVIQ NDMNKEEKVL
DIISDSYSNM HVYDLLIKRK NLNELKKFSK GGNLQNEQKG DEDVKKEDVK KENVNKEEIK
NGNNNNNNDE NENEVDDNTV STTDYLTLDD RKHVLTLTNY IVPIVESFHD NDNLTILVNT
LYNIDLFKII VLKYNGNLYN RILMKYIKKK RKEKRYKLEY VMKKYGIEKH FTKNEVIQKI
KEYNENKIDN YDDCIKWKNT LIQKLQIISE RIKYLYTYMN DKINNMNNIN YKSYFQLCNS
NEIPNIQFIN VIDIQKEEII INGITRINNY INYLNVWIQN VNDCINYVTN CGYNFNYLSN
LNKVKININD LNNNIVDVNN SIHNIEKEDI FKSLSYPKDH STTFEGIHNN MSHKETSSIQ
NKGKEKSNNN IKSDDNNNNN DNYCVGDYLE FLEYDFIDNP DELKRIPYRY SSDFKSFHMF
EYFRKNNNNV IVSLQRIFIC MQLYSLVLCA KKKKDHFEKY TSDVNLNELY YNEKDNFHDN
MNKFKGKNNK YNKKQEYYNQ NNYDCGVKNS YSSSLSTAVE TLTANGIKEA KDDDLNKSSL
NKKKCHDKDN NDQPHYVSTN SSNSDDDDDD GDNNNNKNDN MDDDSYYERN SIFGDNNDDK
DDDDDDSYLD NFSDSDGKKN DPSYKYDIEN NEEMKFYKDL ELRKKNCLYY YRNALFYNGS
SMIPCEENKH FTIPLKGIDN NGANPENFDD GTENMCSFLN MFSKNDNYLN LFKPLIPNIK
ILLFSLNKIL FNKHRCNEPI RKIHEELFKR IVCDVARDKI KLNRKIKKLK KQNNKGDIIN
DLINDLKELR FFEKICYELF KLKSKNYSDD EDSNNRMEES EYSENSNDLS YDEFDSKISK
YPTKVGNEGK KSKDNNNNNN NNMMGDDDNK VNKNEEGNEQ NESAQIKEGK EKKLRDFIQK
EDIRNEDNES YEYYNDQGTE NLDDMNSDEY MNNNNNNNNN NNNNIKRLDD SYNKLLKNKN
INSLIYNLVS KLKMDFYKNY IICDKDIFKT IGRLCFSEIP YVLFLYMDCY KSLGRGDLVD
IPLYLDVFEE NEEMEDDSKG EKNLVYSIRR NNMRNKGDGS SKEKITYHLY ALVISQNKNP
NNNLFIPSYN KVNDMEFNIG NDCNLNSSSY LILKPQINGP WYQIYKNRIT QLKQATDFNE
WKCHRDFYCS CCIYVSDNYF EMQNHFFLQQ FNIKDINFPL YVHTLKEFEI EEEDIFEFDR
NNKNDDMYSS SVNNGLEENY VDELIYELRK FSLDKSEKKL NEQKDGNGVP KSSNDKLVSY
IEEEKYSSHF KKVFEKNNLY KLVDDINEKY NVKYYGSSKT KIFSKKKNVP MNIKEGTFPY
IKTEHDIIYN CLQAHHRLMI NVKEELIDDV IKVNNNNNIC YNFNNHHKSA VCIVLNNHNT
LREDKRRHFF DLKNIIKNYE KFDMNNLNIY NSNIKLMKFS DNFSTGLIIT KNMPLFYSNI
TLKNIINVRN NSIIDSDNER KHLIHKIGED HHHNNNSNNN VEGNISKVYC KKELKGIISS
NETNDTNHTN RTNRTNEMKE ENGLSDIRNY EQNDNITTTN TNDKKLDVVD NISETNDLNL
IRKNGDINKC IEKGNGGGKG RLNVMNNNIQ KCKNKYNTKK ECRNLNILHC NTNNIIINRN
DMNYVKYIMQ LENFLKGMNF NNKFFFNMNN VKDPIRDPFH LEINNVFYNF FEVKMNMNNI
KKNYINNQEK SELHSYYIKT CLNIFKSFFH EYFYLSFINK MEIKKKKKNA FKNFCIALSD
IFFTNLSFKS EEDDDNFEHL QGGIIIYEFY EKRFKKLKLI LKKIFMYLNI ICMIIKYIKL
KKWIFNENFD MHTCKMHDTF FFNFLYFFYN KYSKNCKNNY IKKLCQKSAV KKKQIINGIK
KNMNTVKDED FYFLEFYDKL FVKREPLMQE HLSNKLDKLL TYCTCIISTN ETQIINPKIY
KKKKALFFER TQHNIDCVFR YFSSSLHDEI LYLSKRRNDF NERKKYKEQD KIASEKEDQI
YSIHGNNMNN QDRMYLYIEE NFNSIEETNP KRMEYFLLNL LKNNEKKRKT CVLCYCVRRY
YMNFLNKLEK KLTHDFIEKQ INFIFDNNYL EITKLYRRTK NNLLDPNCNC PSLFNYINID
TVEACIIYLL QTMWKFYISY ILSIPNELEQ YYENLAKKHK RKKYKNSKDE KGWNFIKFLK
EEKTNNLINK YISFNDDSDV ISTNDEENVD RSDDSESNDD KKYSKKKQSN LLLSNFDFVD
ISSIEKLTSG NSSSKNSKKN SNNESIQMDN TNNSNSNNNN KNDNNNDNNN DNNNSFCYYC
ADELNVKNGK ILDTNKNIES NDKSYKNQNI QSNEQSVTPN RNIEENKDHE KKSNNSFYNI
NLDILKQDDL FYKCTNEHLG NATAVLNILQ KKLENEELKK LMKLFHFRGF TEKIPNEECS
KKKCIKNKNV HKNKDDVIVS AHKEKNVKTD SSDDKKKKED NENNNKNKNN IIHNSTNNNV
LKENIHNITQ NEYIKNDLKN ILSKDNLRNE DPSDILENNL ESVFNGTHVD QKFISNFYAN
LKIFKDCLDK NELTKGNNSK DNNNNNNNNN NNNNNKNNMG QENVLMSTIH KVNETMKKYN
INNINEIKSV LIKNGYDIRK CYNGIDLIFL FLSKIKGANV NFINGNNFES NKNMYEILLS
NFKSLNYEKI EKEYYSLDYI LGNFEYIDEN YIEERYASFF NYMDVIFTTQ NMIDDSDIIT
QDIFNPFIDI MNNLFCYGIG LIDNNNNMNS SSNNNNKINS NNSHSNNKNN NNKNKNNNNS
NNNNNNNNSN NNSNNNNSNN NNNNNNNNNN NNNNVNKEII KLNSLYSFLD NLHKCVGSLL
IIDKSYDCKK ELFSFIQYNS FFWYILYKQY NMFLTYYDMT NHCNFFNIFL FHFFNYTFNF
PMDNFFQLDN KLSFEKEQIV NHLFTKFPFL KEEEKSLFHI IMRFLLQEKN HFYNYYYSNE
LSLFIFNAIM SLNNFYLNMK EPNIFSKDYT KLNDYNFVLN MKEVYDIQPA VINKKSKCEE
SSNKIYNVCK SSNNNEEIKS VENDKNGGNS YFDNFILNKE NILDILEKKN EKEIYEIGKV
FDFHIKNESI YFKKRINMLD FVMNDYKKEN FVNYSNSDIN NKIFYVAYNY PIININNKNN
DLFSIYLRTI YKCNEHFRNL NHVFFIYSNY FYNFHNLFLF FNKDNDLFNS LFKLRFKIDQ
AKQMDNFYYD MEDKNNNTYM NKEYVQIKKK NENENNITFS NPIGNYKNYE YAIHNSKSDI
FYIFDDIVYD ITESVNMDYY FKGNRAYVNF VKNKMYGDDN KEDDYIQYDE ISINEANQNK
RKQQIDSSNN NNNVVVNNDD NDNDNMCSNN NYYYNNIYNN DNLCYNRNSI QFDDYMDETI
LSELINNKET DGLNADSSNL GPYNMNNVKN KNNNNNNSNN KRKKNEKNEK IDKIEQFLHE
SELEKDIMNI TFNEKEFLGK DLSFNFYFRS IMYYNKDIIA SNNLEYLMKD KNFITGNVGK
KYFFISLLFN IDYYNVRGMN IGNKVVSNRT MFINKILRDN KGKVLNLKVF HIYNIFSKII
ELYYERKRKG HNMMSLKNSK IASTNGNNNN NNNNNNNNNN NNSKSNLKDE DNTINLFDYK
TDEDFYYKVK MNPSYFFLLY AIKKDYDKRN KNKLIFMNVN SDLEAYIEDK KDNNIYNRFD
LNILLVPISS QIVLSKFNGN LNMFNDNDYP LITFKYLTST YELICIGIIL CSSKLLLQDY
ILNWFFPKLK ERRLVKDDVD LKIDDIYVYE ESELYCLEKI RKVSCNIKKL LKKYSNTIVI
QLKKTNMNNS NIDKINLKCV EYSKLNKYNF CSKCRNNYIC ICEKIEREQL RKKVSLIKQE
EQLYRYFKIY NNNMNMNNNN SNNNNNNNND DLLNMLNNDK EAKKILVLME KMKDLKKAQN
IKAQEKKINK NINSTNTQNV ENDNNKKLES KKEKEKLLFN IYETPNFVQE LEAIENSCRS
SNSSMLSLSS DNISSYSSDD NLFVDEIDSG SYTFNNIVIP NMVSVKDEEN ETQEKTNSSD
LKKSQKVNII KKGNGVKNDM EDIMLKEFHK LSKQRISNIY NLQQSVQLSQ ENVNNNNMVL
NFIKAQENMK NKNMIKDAKK DSKKIPVDVL KDKKGKTSNK EELEKEKEKE EHKLKEQQTV
QEDQKVKDNK KIKDNQKVKD NKKIKDNQKV KDNKKIKQDN IEKTKNDKEE PIQINENTKQ
SNIKIVSLTK SQESLTDNKK TNADNEKQLT VNKIVPKIEN KKTEPAVDVK GKVEKSKLSK
DKSVIVPEVK KEIINNSVIM NNDGSNNENK NKENKNKSSE KSKAKDNNNN KKDNNNNNNN
KKDNNNNNNK KDNNNSNNNN NNNNLSNNGE EDPNDSDSDK DKKKKNKKKD NKNINDDSDD
NNKNKKKLKN NIKNSDDIIN NYFSKNVIEY IEKNDKLENI ATYIYNELIE ITKKKIKKNV
IRLDNLSADN YLTIGEEFLN VMKEILLKIY YKYNEDDYRK HYLRMNNNEN DNNNNNKISL
KKKSETEASN KNVESNDNVD GKLENEYNED ETYMNKFNLC DDEHVIKFLN LIKRKLIYKI
LFPDIQIDTK SKGRNKKNVK KKKQVDIKYV YDIFKREYIF YDKILIMIQH ILDINIRTNI
FLFVYLFAGK LISFVDFDYI LNNTIFYNDY VYYNKVAFED TFFQEESLEE SNKKYYNMND
SINMPLPDSP TTTSNSNNNN NNNNSNNNNN NNNYDKGEVK GLRTSSEQLL NSLNNEGNNN
KLKEDNVMIN EENNVNEDIE KKKKKKSIEE EGSGDDVLIN VNMSKIIYIL ILISNKRIMK
ELIEEKYREE LNEYYYFEMN KKYYDILCNE YNKILNENYA KDLSEHYVKD ELFFESLNII
ELLNNKEYIS TLTDTNKYIK DENKKLNKTH VDDNELIINE YEFMNEKNIN KYINIHNIIK
FKLNFKIAIK KINILQDKIF INNNDNISSG ISFYSLIFKY NSNLINTLHT DIMKTTQNNN
MSIPNMTNYN NYLQVSKKDI DKLKGIYNKY VVLNNKPNVL KDMYILNSEI NTLLSVLYND
INYNNMMNNT YNNILGDTHI SAQNGGYLRA GSNNLSNNKM NNQGGNHINV KRVLTNNLNM
NNMNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNI YINEGGTINM KDLKLNLSKV
IGTNPDIQNE INNNSNHDKK SILKNSSTYS SIYDNNTPTI INKNNNNLKT SVGLNSPTSN
RNKKSVTTFD SKVTLSASYN SNEINNMNED SKLRRLSDQP LSAKSSKIVT PPGNNMNNNT
NNVINNTNNV PNNTNNIINN NVATNKYIKK SKFKRVYNKD IPYICNEGKT WMVIYKPAYY
HCSAYTSHNR YNFLVNINKY SDYFYNILEK ICMKCKIKTK FMCITCKDME NICSKCENIV
SKFCKKCNLL IKKNRDVLKI INSISLNDVV FSGRVESFHL FMMKSFPHLE TVKKWHKLEC
GLCHRIDLET SGSLIIAKTK EAREFLFDQF RKRNVYKEYI LLCHGRIKKK KGFINKSIQT
HEYNNFHSKS HFSLVVKTGG TDAYTEYNCV KVYKLKRKIE DIIQEVQDGK YNCNSTVKKD
INKEIYCNDY YKFLNNNKKN VNIIQRYVII TNILSNHDNI TKKKDTSNNL MTQEDYSSFV
QRKNSHIITN YFSDSQILED KKKIKKKISS THNNKTLNIK GINHILHDDT HYNLNGNINS
RGSYINKNDF TNNMNNNMNN MNNMNTSTLG IYTSGAPSIK KEVCHHLCFR CNSISEDYFL
TDPKEIENYT KEFTLCNVKI HTGRTHQIRV HMRHIGHPLV SDKKYLNPSL SNLDKFWCFR
MFLHSLILEF NNPDYYFFNL NDDMKKKKKM YSSNLYRMPD RTVKAICPLA GDLQTVLDNE
LEISESLEDE NSYINRILKM NINDKRNEAM KNARPIIEDD KFVKHASMDS SKIIHSAREE
TNDKEKISTQ AKIIEVGKKL TTKDEDMLHS KKTDVIQHGD EEEDDEEDDE EDDEEDEEEE
EEDEDEEDVE DVEDIEDVED VEDIEDNYVD DDQYEDNYDD DNDNDDDDEY DHDYDEHINE
EEQEDDDKKN NVNINDSYEE GEEEGDGKLN TKIKKDKKST ENNISVVEEK VKSIDINKEE
DFPDLLSNSK KKNHKDKRNA SKNKNKNKDI LKKNENNIND EKEKKSSNVI TKNNKEQNEI
IDNKNEHVDN KNEIIDNKNE IIVNKNEIIV NKNEIIVNKN EIIDNKNEHI DNKNLLNGSL
DEYNNFKEKN LLSKENLKIN DTTTITTSVE IPNDEHIKKI LLKKPTNKIL RKLNYDDFFT
NKKKKDMNKE NMKKTDEQKI KEEIKQTQDE EDTYLDLIDN EIKKRLRTNF NLLVKEAKIV
INNIIRNSFV FKILFYFFKL KKTLLYLLKC FGIEQIKKEK KVYVEMNILD EFVNNMNENK
ENMPIDFLYE LIHSITYFYK NMHVKKTRKK KEIIIYTLKK HLKNIKSNSN ISKTKRSLIF
QRFYNILFNL NYALNKYGLK TNENLKNQIM KKSKNVYLKI TNVFTIIMNI LNSKVYMKDI
HIKKLMENKA VFSLNTIEQF LLLHKINNET GGEGTNNDKE KKRQTKVSNT QGYNKDNINN
KEKETNKNEE QQQGEAEGKR EGEGEEGEGG EEEECNYLIE QINKIFFKVD KNNEHMLNGV
LLENDDDYLD EEGKVSKKKM KKKKLLNDKE HEKDNEDNDE DNDEDDDDED DDEDDEDDDD
DDDDDDDDDD DDDYDEDYDE DYDEKLVENK KNERSNIIMS KENMNKLNMQ PKNTNNRSSS
SNTIDMKKKI YEKNCMKEKE YRTHDLITNE SIMYKNNEIY DKEKYRRNQE NINHMSSNYM
DKNINHHHEY DNMKKKNYSN NNIYNNNSSN KVSMDEEKRK NLDNNTYPYP MYENVKEIEK
NKVQQNLFHI SKENNNNNND STNNNSVYDY NMSNSNYGSK MGSNNINDST NYYNMREKNI
YNILCNNDSN NYVLFNSNEK YSMNNKISNS ILSNMIMNKQ DNNNININQN NNNNNNNNMN
EGGSETLYSS FTKEIEKLKK EVRKCEESYD KEMVEIQNTK KEIKYLRENN KNDELNNIFS
ELNLENISKY LLSAYEKYGL NVFIKVLVYK NDLGHINDHI KKQDDVNMEF FINISVDKIF
DYLLLKKNII TMVNIKKLKE KFIQGQKIYE LVKNETNKMI IENIKEYNFI FILWKHNNMN
DLYERKQVIF NFIIKIIDKI IPKYIINEYI IIRKNEIYEI MINSLNKKNE YEKKNKDISS
SQYLEKENTY NNLYKKIKDE KRIVDNYSIE MHAEKNITNP IYMSQREDNS TPNSKKNCSN
TNHIMSINHS NMNNTKNTNN HNNNNNNNNY VVNHTTHSTS FYYLHNEKPS NVNTDNQKEI
KDDNVHMKFQ SLPENIRIGV FKNDVNKFYE IYKMMNAGND LNSLMYKNSG HIKNKVNNEP
YSNNYKRNTF CTNDINFAAS AQQSFMNKNV INSMNNNMVS SNNMISSNNI ISNNNMISSN
NMISSNNMIN SNNMISSNNM ISNNMMNNKM NSSNVQIDTE KTRTMNNLQD QFLNLQKNGS
HIYLRNTKDS KNSDIFTFKN NVRSPSQHIT LNEGKENGID MKKKIEQEED KKKIINNNNN
NINSNNNINS NNNINSNNNM NDEDLIKKEI NMNTNDYEEN EKRSSQNKTN YFDNIINNSY
INNKMNNFMI EKKEELNNDM INTFTNKREI NIQTEKAKEQ NIKEPYEVKE TNHNKGIIHM
YYDNEKDINN ITSASGNRHN NIERDKNNIQ TNKTSNNFVK SFKNTISEMF YKKKLNKNTE
IKDEPNQNND TMIYNNLQDM SKKVDEYNEN KNYNHNIVHN NALKSNQMDN EEKKKIELPH
NNNNNNNNSN ERKDLLNNPM SVNMQNAQNV QNTNRSHEYL INSNISLPNF VDENTCSNLK
EKQFESFEKN QMDMTNPNMM MFNIMLGNNL DGIIPNYMEE KHNKNMNKNV NNKNSVSLSS
SMINNGNVIN NRMHTKTINN NSNTCVPNIK YPNFFINKNN IPYTNENNKS LSESNLMNLV
CELNNIEKVE NLSMQNNLNN NINNKRSTLS QMNLLNMENT KGNEQHMRTD LHHNINNNIF
LSNNLCDNKI VNQMFLKKYY NSNFVHYDEE NEEKNKLGTI PRHNTTTTNN NNNDNNNNSN
NNMHLFYNFN GNTPSDINNS YCQQKKIMSS SIIMNNKENN NLHFLNNTYD INGSYATSSI
INNNMNRNNS NSVNSNYLNK TFSIMDPRNN INEYEEKQKI IINRIKQQNI SNTSGNMKNS
SNIRSSSNIR SSNNIKSSSN IKSSSNINAN NNILYQLIDE NILKNTLSNN NPFNEIKNNT
QKTNMDFGLN QLSMYMQNNV TSNLKNNSIT NETHNNNDNM KTNHNNNNNN NNNNNNNNNN
NTSGYPINYL IFQQNQNHSD TNNNNNNNNK NNSNNNNNNI Y
