MLRS_BOVIN
ID MLRS_BOVIN Reviewed; 170 AA.
AC Q0P571;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Myosin regulatory light chain 2, skeletal muscle isoform;
DE AltName: Full=Fast skeletal myosin light chain 2;
DE AltName: Full=MLC2F;
GN Name=MYLPF {ECO:0000250|UniProtKB:P97457};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1] {ECO:0000312|EMBL:AAI20432.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford {ECO:0000312|EMBL:AAI20432.1};
RC TISSUE=Fetal muscle {ECO:0000312|EMBL:AAI20432.1};
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in muscle contraction.
CC {ECO:0000250|UniProtKB:O93409}.
CC -!- SUBUNIT: Myosin is a hexamer of 2 heavy chains and 4 light chains.
CC -!- MISCELLANEOUS: This chain binds calcium. {ECO:0000305}.
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DR EMBL; BC120431; AAI20432.1; -; mRNA.
DR RefSeq; NP_001069115.1; NM_001075647.1.
DR AlphaFoldDB; Q0P571; -.
DR SMR; Q0P571; -.
DR STRING; 9913.ENSBTAP00000028269; -.
DR PaxDb; Q0P571; -.
DR Ensembl; ENSBTAT00000084345; ENSBTAP00000065724; ENSBTAG00000021218.
DR GeneID; 514106; -.
DR KEGG; bta:514106; -.
DR CTD; 29895; -.
DR VEuPathDB; HostDB:ENSBTAG00000021218; -.
DR VGNC; VGNC:31809; MYL11.
DR eggNOG; KOG0031; Eukaryota.
DR GeneTree; ENSGT00940000159038; -.
DR HOGENOM; CLU_061288_9_0_1; -.
DR InParanoid; Q0P571; -.
DR OMA; EDVKNMW; -.
DR OrthoDB; 1435392at2759; -.
DR TreeFam; TF314218; -.
DR Proteomes; UP000009136; Chromosome 25.
DR Bgee; ENSBTAG00000021218; Expressed in biceps femoris and 87 other tissues.
DR ExpressionAtlas; Q0P571; baseline.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0008307; F:structural constituent of muscle; IEA:Ensembl.
DR GO; GO:0006936; P:muscle contraction; IEA:Ensembl.
DR GO; GO:0007519; P:skeletal muscle tissue development; IBA:GO_Central.
DR CDD; cd00051; EFh; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR Pfam; PF13405; EF-hand_6; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 3.
PE 2: Evidence at transcript level;
KW Calcium; Metal-binding; Methylation; Motor protein; Muscle protein; Myosin;
KW Phosphoprotein; Reference proteome; Repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P02608"
FT CHAIN 2..170
FT /note="Myosin regulatory light chain 2, skeletal muscle
FT isoform"
FT /evidence="ECO:0000250|UniProtKB:P02608"
FT /id="PRO_0000283745"
FT DOMAIN 26..61
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 96..131
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 132..167
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 39
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 41
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 43
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 50
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT MOD_RES 2
FT /note="N,N,N-trimethylalanine"
FT /evidence="ECO:0000250|UniProtKB:P02608"
FT MOD_RES 16
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P97457"
FT MOD_RES 17
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P97457"
FT MOD_RES 26
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P04466"
FT MOD_RES 36
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P04466"
FT MOD_RES 76
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P04466"
FT MOD_RES 102
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:P04466"
SQ SEQUENCE 170 AA; 19013 MW; 1B9DF66FD081D2E1 CRC64;
MAPKKAKRRA AAEGGSSSVF SMFDQTQIQE FKEAFTVIDQ NRDGIIDKED LRDTFAAMGR
LNVKNEELDA MMKEASGPIN FTVFLNMFGE KLKGADPEDV ITGAFKVLDP EGKGTIKKKF
LEELLTTQCD RFSQEEIKNM WAAFPPDVGG NVDYKNICYV ITHGDAKDQE