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MLRS_BOVIN
ID   MLRS_BOVIN              Reviewed;         170 AA.
AC   Q0P571;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Myosin regulatory light chain 2, skeletal muscle isoform;
DE   AltName: Full=Fast skeletal myosin light chain 2;
DE   AltName: Full=MLC2F;
GN   Name=MYLPF {ECO:0000250|UniProtKB:P97457};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1] {ECO:0000312|EMBL:AAI20432.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford {ECO:0000312|EMBL:AAI20432.1};
RC   TISSUE=Fetal muscle {ECO:0000312|EMBL:AAI20432.1};
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in muscle contraction.
CC       {ECO:0000250|UniProtKB:O93409}.
CC   -!- SUBUNIT: Myosin is a hexamer of 2 heavy chains and 4 light chains.
CC   -!- MISCELLANEOUS: This chain binds calcium. {ECO:0000305}.
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DR   EMBL; BC120431; AAI20432.1; -; mRNA.
DR   RefSeq; NP_001069115.1; NM_001075647.1.
DR   AlphaFoldDB; Q0P571; -.
DR   SMR; Q0P571; -.
DR   STRING; 9913.ENSBTAP00000028269; -.
DR   PaxDb; Q0P571; -.
DR   Ensembl; ENSBTAT00000084345; ENSBTAP00000065724; ENSBTAG00000021218.
DR   GeneID; 514106; -.
DR   KEGG; bta:514106; -.
DR   CTD; 29895; -.
DR   VEuPathDB; HostDB:ENSBTAG00000021218; -.
DR   VGNC; VGNC:31809; MYL11.
DR   eggNOG; KOG0031; Eukaryota.
DR   GeneTree; ENSGT00940000159038; -.
DR   HOGENOM; CLU_061288_9_0_1; -.
DR   InParanoid; Q0P571; -.
DR   OMA; EDVKNMW; -.
DR   OrthoDB; 1435392at2759; -.
DR   TreeFam; TF314218; -.
DR   Proteomes; UP000009136; Chromosome 25.
DR   Bgee; ENSBTAG00000021218; Expressed in biceps femoris and 87 other tissues.
DR   ExpressionAtlas; Q0P571; baseline.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0008307; F:structural constituent of muscle; IEA:Ensembl.
DR   GO; GO:0006936; P:muscle contraction; IEA:Ensembl.
DR   GO; GO:0007519; P:skeletal muscle tissue development; IBA:GO_Central.
DR   CDD; cd00051; EFh; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   Pfam; PF13405; EF-hand_6; 1.
DR   SMART; SM00054; EFh; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 3.
PE   2: Evidence at transcript level;
KW   Calcium; Metal-binding; Methylation; Motor protein; Muscle protein; Myosin;
KW   Phosphoprotein; Reference proteome; Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P02608"
FT   CHAIN           2..170
FT                   /note="Myosin regulatory light chain 2, skeletal muscle
FT                   isoform"
FT                   /evidence="ECO:0000250|UniProtKB:P02608"
FT                   /id="PRO_0000283745"
FT   DOMAIN          26..61
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          96..131
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          132..167
FT                   /note="EF-hand 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         39
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         41
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         43
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   BINDING         50
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   MOD_RES         2
FT                   /note="N,N,N-trimethylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:P02608"
FT   MOD_RES         16
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P97457"
FT   MOD_RES         17
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P97457"
FT   MOD_RES         26
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P04466"
FT   MOD_RES         36
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P04466"
FT   MOD_RES         76
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P04466"
FT   MOD_RES         102
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P04466"
SQ   SEQUENCE   170 AA;  19013 MW;  1B9DF66FD081D2E1 CRC64;
     MAPKKAKRRA AAEGGSSSVF SMFDQTQIQE FKEAFTVIDQ NRDGIIDKED LRDTFAAMGR
     LNVKNEELDA MMKEASGPIN FTVFLNMFGE KLKGADPEDV ITGAFKVLDP EGKGTIKKKF
     LEELLTTQCD RFSQEEIKNM WAAFPPDVGG NVDYKNICYV ITHGDAKDQE
 
 
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