6PGL_CAEEL
ID 6PGL_CAEEL Reviewed; 269 AA.
AC O18229; Q2EEL9;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2001, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Putative 6-phosphogluconolactonase;
DE Short=6PGL;
DE EC=3.1.1.31;
GN ORFNames=Y57G11C.3 {ECO:0000312|WormBase:Y57G11C.3a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP SUBCELLULAR LOCATION.
RX PubMed=32338603; DOI=10.7554/elife.56731;
RA Manage K.I., Rogers A.K., Wallis D.C., Uebel C.J., Anderson D.C.,
RA Nguyen D.A.H., Arca K., Brown K.C., Cordeiro Rodrigues R.J.,
RA de Albuquerque B.F.M., Ketting R.F., Montgomery T.A., Phillips C.M.;
RT "A Tudor domain protein, SIMR-1, promotes siRNA production at piRNA-
RT targeted mRNAs in C. elegans.";
RL Elife 9:0-0(2020).
CC -!- FUNCTION: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
CC {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate
CC + H(+); Xref=Rhea:RHEA:12556, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57955, ChEBI:CHEBI:58759; EC=3.1.1.31;
CC -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC 2/3.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:32338603}.
CC Note=Localizes to the nucleus of germ cells.
CC {ECO:0000269|PubMed:32338603}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a {ECO:0000312|WormBase:Y57G11C.3a};
CC IsoId=O18229-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:Y57G11C.3b};
CC IsoId=O18229-2; Sequence=VSP_020096;
CC -!- SIMILARITY: Belongs to the glucosamine/galactosamine-6-phosphate
CC isomerase family. 6-phosphogluconolactonase subfamily. {ECO:0000305}.
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DR EMBL; BX284604; CAB16505.2; -; Genomic_DNA.
DR EMBL; BX284604; CAJ76962.1; -; Genomic_DNA.
DR PIR; F88904; F88904.
DR PIR; T27244; T27244.
DR RefSeq; NP_001041049.1; NM_001047584.3.
DR RefSeq; NP_001041050.1; NM_001047585.1.
DR AlphaFoldDB; O18229; -.
DR SMR; O18229; -.
DR BioGRID; 43481; 8.
DR DIP; DIP-26505N; -.
DR STRING; 6239.Y57G11C.3a; -.
DR EPD; O18229; -.
DR PaxDb; O18229; -.
DR PeptideAtlas; O18229; -.
DR PRIDE; O18229; -.
DR EnsemblMetazoa; Y57G11C.3a.1; Y57G11C.3a.1; WBGene00013301. [O18229-1]
DR EnsemblMetazoa; Y57G11C.3b.1; Y57G11C.3b.1; WBGene00013301. [O18229-2]
DR UCSC; Y57G11C.3a; c. elegans. [O18229-1]
DR WormBase; Y57G11C.3a; CE24473; WBGene00013301; -. [O18229-1]
DR WormBase; Y57G11C.3b; CE14930; WBGene00013301; -. [O18229-2]
DR eggNOG; KOG3147; Eukaryota.
DR GeneTree; ENSGT00550000075110; -.
DR HOGENOM; CLU_053947_0_0_1; -.
DR InParanoid; O18229; -.
DR OMA; IAMSQST; -.
DR OrthoDB; 1420529at2759; -.
DR PhylomeDB; O18229; -.
DR Reactome; R-CEL-71336; Pentose phosphate pathway.
DR UniPathway; UPA00115; UER00409.
DR PRO; PR:O18229; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00013301; Expressed in embryo and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:WormBase.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0030017; C:sarcomere; HDA:WormBase.
DR GO; GO:0055120; C:striated muscle dense body; HDA:WormBase.
DR GO; GO:0017057; F:6-phosphogluconolactonase activity; IBA:GO_Central.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0009051; P:pentose-phosphate shunt, oxidative branch; IBA:GO_Central.
DR CDD; cd01400; 6PGL; 1.
DR InterPro; IPR005900; 6-phosphogluconolactonase_DevB.
DR InterPro; IPR006148; Glc/Gal-6P_isomerase.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR InterPro; IPR039104; PGLS.
DR PANTHER; PTHR11054; PTHR11054; 1.
DR Pfam; PF01182; Glucosamine_iso; 1.
DR SUPFAM; SSF100950; SSF100950; 1.
DR TIGRFAMs; TIGR01198; pgl; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Hydrolase; Nucleus; Reference proteome.
FT CHAIN 1..269
FT /note="Putative 6-phosphogluconolactonase"
FT /id="PRO_0000090080"
FT REGION 248..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..12
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_020096"
SQ SEQUENCE 269 AA; 30414 MW; 8E79075016E5071A CRC64;
MCLVNEFVSN SNMKPALNVS GDEKELILQL RRYLEEKLTY LLDQNGTVSI GVSGGSMPRV
FSKAILSLPQ EQLNWKRIRI FMVDERNVDL DSEESNQGEY LRLFPNELRD VFVPMQIFKD
PCLTAQHYEI SLRKYLLPEQ LNNTARFDIL FLGVGPDGHT ASIFPGKERL EKITELNWVS
VITDSPKPPP SRITLTLQTL QHAKNVAFII CGKQKAEIVR GICDRDQKYP AAQARPFNDK
LTLFLDEDAA TGVPDRDSSD SDSPPPFDG
