ID   MLTG_HAEIN              Reviewed;         347 AA.
AC   P44720;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Endolytic murein transglycosylase {ECO:0000255|HAMAP-Rule:MF_02065};
DE            EC=4.2.2.- {ECO:0000255|HAMAP-Rule:MF_02065};
DE   AltName: Full=Peptidoglycan polymerization terminase {ECO:0000255|HAMAP-Rule:MF_02065};
GN   Name=mltG {ECO:0000255|HAMAP-Rule:MF_02065}; OrderedLocusNames=HI_0457;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Functions as a peptidoglycan terminase that cleaves nascent
CC       peptidoglycan strands endolytically to terminate their elongation.
CC       {ECO:0000255|HAMAP-Rule:MF_02065}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_02065}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_02065}.
CC   -!- SIMILARITY: Belongs to the transglycosylase MltG family.
CC       {ECO:0000255|HAMAP-Rule:MF_02065}.
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DR   EMBL; L42023; AAC22115.1; -; Genomic_DNA.
DR   PIR; E64069; E64069.
DR   RefSeq; NP_438618.1; NC_000907.1.
DR   RefSeq; WP_005693707.1; NC_000907.1.
DR   AlphaFoldDB; P44720; -.
DR   SMR; P44720; -.
DR   STRING; 71421.HI_0457; -.
DR   PRIDE; P44720; -.
DR   EnsemblBacteria; AAC22115; AAC22115; HI_0457.
DR   KEGG; hin:HI_0457; -.
DR   PATRIC; fig|71421.8.peg.477; -.
DR   eggNOG; COG1559; Bacteria.
DR   HOGENOM; CLU_025574_0_2_6; -.
DR   OMA; IAMPGKA; -.
DR   PhylomeDB; P44720; -.
DR   BioCyc; HINF71421:G1GJ1-473-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008932; F:lytic endotransglycosylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd08010; MltG_like; 1.
DR   HAMAP; MF_02065; MltG; 1.
DR   InterPro; IPR003770; MLTG-like.
DR   PANTHER; PTHR30518; PTHR30518; 1.
DR   Pfam; PF02618; YceG; 1.
DR   TIGRFAMs; TIGR00247; TIGR00247; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Cell wall biogenesis/degradation;
KW   Lyase; Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..347
FT                   /note="Endolytic murein transglycosylase"
FT                   /id="PRO_0000168818"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02065"
FT   SITE            224
FT                   /note="Important for catalytic activity"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02065"
SQ   SEQUENCE   347 AA;  39621 MW;  A21D559C66308F3D CRC64;
     MKKFLIAILL LILILAGVAS FSYYKMTEFV KTPVNVQADE LLTIERGTTS SKLATLFEQE
     KLIADGKLLP YLLKLKPELN KIKAGTYSLE NVKTVQDLLD LLNSGKEVQF NVKWIEGKTF
     KDWRKDLENA PHLVQTLKDK SNEEIFALLD LPDIGQNLEL KNVEGWLYPD TYNYTPKSTD
     LELLKRSAER MKKALNKAWN ERDEDLPLAN PYEMLILASI VEKETGIANE RAKVASVFIN
     RLKAKMKLQT DPTVIYGMGE NYNGNIRKKD LETKTPYNTY VIDGLPPTPI AMPSESSLQA
     VANPEKTDFY YFVADGSGGH KFTRNLNEHN KAVQEYLRWY RSQKNAK