MLXPL_HUMAN
ID MLXPL_HUMAN Reviewed; 852 AA.
AC Q9NP71; C5HU02; C5HU03; C5HU04; Q96E48; Q9BY03; Q9BY04; Q9BY05; Q9BY06;
AC Q9Y2P3;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 183.
DE RecName: Full=Carbohydrate-responsive element-binding protein;
DE Short=ChREBP;
DE AltName: Full=Class D basic helix-loop-helix protein 14;
DE Short=bHLHd14;
DE AltName: Full=MLX interactor;
DE AltName: Full=MLX-interacting protein-like;
DE AltName: Full=WS basic-helix-loop-helix leucine zipper protein;
DE Short=WS-bHLH;
DE AltName: Full=Williams-Beuren syndrome chromosomal region 14 protein;
GN Name=MLXIPL; Synonyms=BHLHD14, MIO, WBSCR14;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE (ISOFORM 1), AND INVOLVEMENT IN WBS.
RX PubMed=10780788; DOI=10.1038/sj.ejhg.5200435;
RA de Luis O., Valero M.C., Perez Jurado L.A.;
RT "WBSCR14, a putative transcription factor gene deleted in Williams-Beuren
RT syndrome: complete characterisation of the human gene and the mouse
RT ortholog.";
RL Eur. J. Hum. Genet. 8:215-222(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 5), AND SUBUNIT.
RX PubMed=11230181; DOI=10.1093/hmg/10.6.617;
RA Cairo S., Merla G., Urbinati F., Ballabio A., Reymond A.;
RT "WBSCR14, a gene mapping to the Williams-Beuren syndrome deleted region, is
RT a new member of the Mlx transcription factor network.";
RL Hum. Mol. Genet. 10:617-627(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG NHLBI resequencing and genotyping service (RS&G);
RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 620-852 (ISOFORM 4).
RX PubMed=9860302; DOI=10.1007/s004390050874;
RA Meng X., Lu X., Li Z., Green E.D., Massa H., Trask B.J., Morris C.A.,
RA Keating M.T.;
RT "Complete physical map of the common deletion region in Williams syndrome
RT and identification and characterization of three novel genes.";
RL Hum. Genet. 103:590-599(1998).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
RX PubMed=14759258; DOI=10.1186/gb-2004-5-2-r8;
RA Hillman R.T., Green R.E., Brenner S.E.;
RT "An unappreciated role for RNA surveillance.";
RL Genome Biol. 5:R8.1-R8.16(2004).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-196; SER-602 AND SER-614, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20; SER-23; SER-25; THR-27;
RP SER-29; SER-602 AND SER-631, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE
RP SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- FUNCTION: Transcriptional repressor. Binds to the canonical and non-
CC canonical E box sequences 5'-CACGTG-3' (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Binds DNA as a heterodimer with TCFL4/MLX.
CC {ECO:0000269|PubMed:11230181}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1; Synonyms=Alpha;
CC IsoId=Q9NP71-1; Sequence=Displayed;
CC Name=2; Synonyms=Beta;
CC IsoId=Q9NP71-2; Sequence=VSP_002171;
CC Name=3; Synonyms=Gamma;
CC IsoId=Q9NP71-3; Sequence=VSP_002170;
CC Name=4; Synonyms=Delta;
CC IsoId=Q9NP71-4; Sequence=VSP_002170, VSP_002171;
CC Name=5; Synonyms=Epsilon;
CC IsoId=Q9NP71-5; Sequence=VSP_002168, VSP_002169;
CC Name=6;
CC IsoId=Q9NP71-6; Sequence=VSP_002167, VSP_002172, VSP_002173;
CC -!- TISSUE SPECIFICITY: Expressed in liver, heart, kidney, cerebellum and
CC intestinal tissues.
CC -!- PTM: Phosphorylation at Ser-556 by AMPK inactivates the DNA-binding
CC activity. {ECO:0000250}.
CC -!- DISEASE: Note=WBSCR14 is located in the Williams-Beuren syndrome (WBS)
CC critical region. WBS results from a hemizygous deletion of several
CC genes on chromosome 7q11.23, thought to arise as a consequence of
CC unequal crossing over between highly homologous low-copy repeat
CC sequences flanking the deleted region. Haploinsufficiency of WBSCR14
CC may be the cause of certain cardiovascular and musculo-skeletal
CC abnormalities observed in the disease. {ECO:0000269|PubMed:10780788}.
CC -!- MISCELLANEOUS: [Isoform 5]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
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DR EMBL; AF156673; AAF68176.1; -; Genomic_DNA.
DR EMBL; AF156603; AAF68174.1; -; mRNA.
DR EMBL; AF245470; AAK20935.1; -; mRNA.
DR EMBL; AF245471; AAK20936.1; -; mRNA.
DR EMBL; AF245472; AAK20937.1; -; mRNA.
DR EMBL; AF245473; AAK20938.1; -; mRNA.
DR EMBL; AF245474; AAK20939.1; -; mRNA.
DR EMBL; FJ515858; ACS13745.1; -; Genomic_DNA.
DR EMBL; FJ515858; ACS13746.1; -; Genomic_DNA.
DR EMBL; FJ515858; ACS13748.1; -; Genomic_DNA.
DR EMBL; AF056184; AAD28084.1; -; mRNA.
DR EMBL; CH471200; EAW69660.1; -; Genomic_DNA.
DR EMBL; CH471200; EAW69661.1; -; Genomic_DNA.
DR EMBL; CH471200; EAW69662.1; -; Genomic_DNA.
DR EMBL; BC012925; AAH12925.1; -; mRNA.
DR CCDS; CCDS47605.1; -. [Q9NP71-2]
DR CCDS; CCDS47606.1; -. [Q9NP71-3]
DR CCDS; CCDS5553.1; -. [Q9NP71-1]
DR CCDS; CCDS5554.1; -. [Q9NP71-4]
DR RefSeq; NP_116569.1; NM_032951.2. [Q9NP71-1]
DR RefSeq; NP_116570.1; NM_032952.2. [Q9NP71-2]
DR RefSeq; NP_116571.1; NM_032953.2. [Q9NP71-3]
DR RefSeq; NP_116572.1; NM_032954.2. [Q9NP71-4]
DR PDB; 6MJL; X-ray; 2.50 A; A=168-176.
DR PDB; 6YGJ; X-ray; 2.07 A; B/I=117-137.
DR PDBsum; 6MJL; -.
DR PDBsum; 6YGJ; -.
DR AlphaFoldDB; Q9NP71; -.
DR SMR; Q9NP71; -.
DR BioGRID; 119275; 21.
DR IntAct; Q9NP71; 6.
DR STRING; 9606.ENSP00000320886; -.
DR iPTMnet; Q9NP71; -.
DR PhosphoSitePlus; Q9NP71; -.
DR BioMuta; MLXIPL; -.
DR DMDM; 20140871; -.
DR jPOST; Q9NP71; -.
DR MassIVE; Q9NP71; -.
DR MaxQB; Q9NP71; -.
DR PaxDb; Q9NP71; -.
DR PeptideAtlas; Q9NP71; -.
DR PRIDE; Q9NP71; -.
DR ProteomicsDB; 81900; -. [Q9NP71-1]
DR ProteomicsDB; 81901; -. [Q9NP71-2]
DR ProteomicsDB; 81902; -. [Q9NP71-3]
DR ProteomicsDB; 81903; -. [Q9NP71-4]
DR ProteomicsDB; 81904; -. [Q9NP71-5]
DR ProteomicsDB; 81905; -. [Q9NP71-6]
DR Antibodypedia; 14346; 354 antibodies from 30 providers.
DR DNASU; 51085; -.
DR Ensembl; ENST00000313375.8; ENSP00000320886.3; ENSG00000009950.16. [Q9NP71-1]
DR Ensembl; ENST00000345114.9; ENSP00000343767.5; ENSG00000009950.16. [Q9NP71-5]
DR Ensembl; ENST00000354613.5; ENSP00000346629.1; ENSG00000009950.16. [Q9NP71-4]
DR Ensembl; ENST00000414749.6; ENSP00000412330.2; ENSG00000009950.16. [Q9NP71-3]
DR Ensembl; ENST00000429400.6; ENSP00000406296.2; ENSG00000009950.16. [Q9NP71-2]
DR GeneID; 51085; -.
DR KEGG; hsa:51085; -.
DR MANE-Select; ENST00000313375.8; ENSP00000320886.3; NM_032951.3; NP_116569.1.
DR UCSC; uc003tyk.1; human. [Q9NP71-1]
DR CTD; 51085; -.
DR DisGeNET; 51085; -.
DR GeneCards; MLXIPL; -.
DR HGNC; HGNC:12744; MLXIPL.
DR HPA; ENSG00000009950; Tissue enriched (liver).
DR MalaCards; MLXIPL; -.
DR MIM; 605678; gene.
DR neXtProt; NX_Q9NP71; -.
DR OpenTargets; ENSG00000009950; -.
DR Orphanet; 904; Williams syndrome.
DR PharmGKB; PA37353; -.
DR VEuPathDB; HostDB:ENSG00000009950; -.
DR eggNOG; KOG3582; Eukaryota.
DR GeneTree; ENSGT00940000159210; -.
DR HOGENOM; CLU_007471_1_1_1; -.
DR InParanoid; Q9NP71; -.
DR OMA; EYHTSSM; -.
DR OrthoDB; 388166at2759; -.
DR PhylomeDB; Q9NP71; -.
DR TreeFam; TF324749; -.
DR PathwayCommons; Q9NP71; -.
DR Reactome; R-HSA-163358; PKA-mediated phosphorylation of key metabolic factors.
DR Reactome; R-HSA-163680; AMPK inhibits chREBP transcriptional activation activity.
DR Reactome; R-HSA-163765; ChREBP activates metabolic gene expression.
DR Reactome; R-HSA-163767; PP2A-mediated dephosphorylation of key metabolic factors.
DR SignaLink; Q9NP71; -.
DR SIGNOR; Q9NP71; -.
DR BioGRID-ORCS; 51085; 10 hits in 1097 CRISPR screens.
DR ChiTaRS; MLXIPL; human.
DR GeneWiki; MLXIPL; -.
DR GenomeRNAi; 51085; -.
DR Pharos; Q9NP71; Tbio.
DR PRO; PR:Q9NP71; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q9NP71; protein.
DR Bgee; ENSG00000009950; Expressed in right lobe of liver and 140 other tissues.
DR ExpressionAtlas; Q9NP71; baseline and differential.
DR Genevisible; Q9NP71; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005737; C:cytoplasm; ISS:BHF-UCL.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; ISS:BHF-UCL.
DR GO; GO:0005667; C:transcription regulator complex; NAS:UniProtKB.
DR GO; GO:0035538; F:carbohydrate response element binding; TAS:BHF-UCL.
DR GO; GO:0003677; F:DNA binding; NAS:BHF-UCL.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:BHF-UCL.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IPI:BHF-UCL.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IPI:BHF-UCL.
DR GO; GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc.
DR GO; GO:0097009; P:energy homeostasis; ISS:UniProtKB.
DR GO; GO:0055089; P:fatty acid homeostasis; ISS:UniProtKB.
DR GO; GO:0042593; P:glucose homeostasis; ISS:BHF-UCL.
DR GO; GO:0010255; P:glucose mediated signaling pathway; ISS:BHF-UCL.
DR GO; GO:0090324; P:negative regulation of oxidative phosphorylation; IMP:BHF-UCL.
DR GO; GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IMP:BHF-UCL.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:BHF-UCL.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:BHF-UCL.
DR GO; GO:0045723; P:positive regulation of fatty acid biosynthetic process; ISS:BHF-UCL.
DR GO; GO:0045821; P:positive regulation of glycolytic process; IMP:BHF-UCL.
DR GO; GO:0046889; P:positive regulation of lipid biosynthetic process; IMP:BHF-UCL.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:BHF-UCL.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:BHF-UCL.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:BHF-UCL.
DR GO; GO:0070328; P:triglyceride homeostasis; NAS:BHF-UCL.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; DNA-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repressor; Transcription; Transcription regulation;
KW Williams-Beuren syndrome.
FT CHAIN 1..852
FT /note="Carbohydrate-responsive element-binding protein"
FT /id="PRO_0000127504"
FT DOMAIN 649..703
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 54..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..527
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 548..648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 703..724
FT /note="Leucine-zipper"
FT COMPBIAS 347..365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..505
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..589
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 20
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 23
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 25
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 27
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 29
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 196
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 556
FT /note="Phosphoserine; by AMPK"
FT /evidence="ECO:0000250|UniProtKB:Q8VIP2"
FT MOD_RES 602
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163,
FT ECO:0007744|PubMed:24275569"
FT MOD_RES 614
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 631
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT VAR_SEQ 176..268
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_002167"
FT VAR_SEQ 558..575
FT /note="QETVPEFPCTFLPPTPAP -> AVNGGCQGTSAPCQALGL (in isoform
FT 5)"
FT /evidence="ECO:0000303|PubMed:11230181"
FT /id="VSP_002168"
FT VAR_SEQ 576..852
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:11230181"
FT /id="VSP_002169"
FT VAR_SEQ 647..648
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:11230181,
FT ECO:0000303|PubMed:9860302"
FT /id="VSP_002170"
FT VAR_SEQ 687..705
FT /note="Missing (in isoform 2 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:11230181,
FT ECO:0000303|PubMed:9860302"
FT /id="VSP_002171"
FT VAR_SEQ 814..815
FT /note="TV -> ST (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_002172"
FT VAR_SEQ 816..852
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_002173"
FT VARIANT 241
FT /note="Q -> H (in dbSNP:rs3812316)"
FT /id="VAR_049556"
FT VARIANT 244
FT /note="D -> E (in dbSNP:rs34922362)"
FT /id="VAR_049557"
FT CONFLICT 558
FT /note="Missing (in Ref. 6; AAH12925)"
FT /evidence="ECO:0000305"
FT HELIX 120..134
FT /evidence="ECO:0007829|PDB:6YGJ"
SQ SEQUENCE 852 AA; 93073 MW; D49E5C3D7C0A72EC CRC64;
MAGALAGLAA GLQVPRVAPS PDSDSDTDSE DPSLRRSAGG LLRSQVIHSG HFMVSSPHSD
SLPRRRDQEG SVGPSDFGPR SIDPTLTRLF ECLSLAYSGK LVSPKWKNFK GLKLLCRDKI
RLNNAIWRAW YIQYVKRRKS PVCGFVTPLQ GPEADAHRKP EAVVLEGNYW KRRIEVVMRE
YHKWRIYYKK RLRKPSREDD LLAPKQAEGR WPPPEQWCKQ LFSSVVPVLL GDPEEEPGGR
QLLDLNCFLS DISDTLFTMT QSGPSPLQLP PEDAYVGNAD MIQPDLTPLQ PSLDDFMDIS
DFFTNSRLPQ PPMPSNFPEP PSFSPVVDSL FSSGTLGPEV PPASSAMTHL SGHSRLQARN
SCPGPLDSSA FLSSDFLLPE DPKPRLPPPP VPPPLLHYPP PAKVPGLEPC PPPPFPPMAP
PTALLQEEPL FSPRFPFPTV PPAPGVSPLP APAAFPPTPQ SVPSPAPTPF PIELLPLGYS
EPAFGPCFSM PRGKPPAPSP RGQKASPPTL APATASPPTT AGSNNPCLTQ LLTAAKPEQA
LEPPLVSSTL LRSPGSPQET VPEFPCTFLP PTPAPTPPRP PPGPATLAPS RPLLVPKAER
LSPPAPSGSE RRLSGDLSSM PGPGTLSVRV SPPQPILSRG RPDSNKTENR RITHISAEQK
RRFNIKLGFD TLHGLVSTLS AQPSLKVSKA TTLQKTAEYI LMLQQERAGL QEEAQQLRDE
IEELNAAINL CQQQLPATGV PITHQRFDQM RDMFDDYVRT RTLHNWKFWV FSILIRPLFE
SFNGMVSTAS VHTLRQTSLA WLDQYCSLPA LRPTVLNSLR QLGTSTSILT DPGRIPEQAT
RAVTEGTLGK PL
