ID   MMAA1_CAEBR             Reviewed;         412 AA.
AC   A8XGZ9;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Methylmalonic aciduria type A homolog, mitochondrial;
DE            EC=3.6.-.-;
DE   AltName: Full=Methylmalonic aciduria type A protein 1;
DE   Flags: Precursor;
GN   Name=mmaa-1 {ECO:0000312|EMBL:CAP31923.2}; ORFNames=CBG13064;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1] {ECO:0000312|EMBL:CAP31923.2}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16 {ECO:0000312|EMBL:CAP31923.2};
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: May have GTPase activity. May also bind and hydrolyze ATP.
CC       May function as chaperone. Likely to have a role in propionyl-CoA
CC       metabolism and adenosylcobalamin synthesis (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB
CC       subfamily. {ECO:0000305}.
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DR   EMBL; HE601401; CAP31923.2; -; Genomic_DNA.
DR   AlphaFoldDB; A8XGZ9; -.
DR   SMR; A8XGZ9; -.
DR   STRING; 6238.CBG13064; -.
DR   WormBase; CBG13064; CBP40019; WBGene00033893; Cbr-mmaa-1.
DR   eggNOG; ENOG502QR2W; Eukaryota.
DR   HOGENOM; CLU_043725_2_2_1; -.
DR   InParanoid; A8XGZ9; -.
DR   OMA; WMWERID; -.
DR   OrthoDB; 817699at2759; -.
DR   Proteomes; UP000008549; Chromosome II.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR005129; GTPase_ArgK.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR23408; PTHR23408; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00750; lao; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; GTP-binding; Hydrolase; Mitochondrion;
KW   Nucleotide-binding; Reference proteome; Transit peptide.
FT   TRANSIT         1..15
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000305"
FT   CHAIN           16..412
FT                   /note="Methylmalonic aciduria type A homolog,
FT                   mitochondrial"
FT                   /id="PRO_0000395431"
FT   BINDING         132..140
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         275
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         311..313
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   412 AA;  45794 MW;  34B55FEAA0FC9A15 CRC64;
     MVVRALVRAH PLSRISCRYS SLAASSFNPK PYIPSVSGVQ KSLPFDNLLE QYSRVHWDDT
     VTYDDPTVQR LFKNLMSGSR AALASAITLV ESRHPTKRAQ GNMLLKMVLD EEREKYKKYG
     RDSMIFRVGI SGSPGVGKSS FIEALGAELT ENRGKKVAVL TIDPTSAMTG GSVLGDLTRM
     QELSRNPRAY IRQSPTSGSL GGVTRGIHEA VILCEGAGYD IVIIETVGVG QSETSVSDMC
     DMMCLLLSPA HGDELQGVKR GIMEMSDLLV VTKDDGDLQA KAKMTQAEYI SALKFMRPRL
     DVWSPKVMRS SIMNKESVSA VCTSLYEFWD TIGESGDLER RRQDQMKKWM WNHVKDEIMA
     VFQKHPKIIH LKNHKIFINL LLQAPKLEKD ISSGKITPGL AAETMIRTFF GV