MMAD_CHICK
ID MMAD_CHICK Reviewed; 296 AA.
AC Q5ZKP2;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Cobalamin trafficking protein CblD;
DE AltName: Full=CblD {ECO:0000250|UniProtKB:Q9H3L0};
DE AltName: Full=Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial;
DE Flags: Precursor;
GN Name=MMADHC; ORFNames=RCJMB04_9n6;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Involved in cobalamin metabolism and trafficking. Plays a
CC role in regulating the biosynthesis and the proportion of two
CC coenzymes, methylcob(III)alamin (MeCbl) and 5'-deoxyadenosylcobalamin
CC (AdoCbl). Promotes oxidation of cob(II)alamin bound to MMACHC. The
CC processing of cobalamin in the cytosol occurs in a multiprotein complex
CC composed of at least MMACHC, MMADHC, MTRR (methionine synthase
CC reductase) and MTR (methionine synthase) which may contribute to
CC shuttle safely and efficiently cobalamin towards MTR in order to
CC produce methionine. {ECO:0000250|UniProtKB:Q9H3L0}.
CC -!- SUBUNIT: Heterodimer with MMACHC. Forms a multiprotein complex with
CC MMACHC, MTR and MTRR. {ECO:0000250|UniProtKB:Q9H3L0}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H3L0}.
CC Mitochondrion {ECO:0000250|UniProtKB:Q9H3L0}.
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DR EMBL; AJ720042; CAG31701.1; -; mRNA.
DR RefSeq; NP_001008477.1; NM_001008477.1.
DR AlphaFoldDB; Q5ZKP2; -.
DR SMR; Q5ZKP2; -.
DR STRING; 9031.ENSGALP00000020355; -.
DR PaxDb; Q5ZKP2; -.
DR Ensembl; ENSGALT00000020382; ENSGALP00000020355; ENSGALG00000012473.
DR GeneID; 424311; -.
DR KEGG; gga:424311; -.
DR CTD; 27249; -.
DR VEuPathDB; HostDB:geneid_424311; -.
DR eggNOG; KOG3994; Eukaryota.
DR GeneTree; ENSGT00390000015050; -.
DR HOGENOM; CLU_066240_0_0_1; -.
DR InParanoid; Q5ZKP2; -.
DR OMA; IWPDETM; -.
DR OrthoDB; 1363001at2759; -.
DR PhylomeDB; Q5ZKP2; -.
DR TreeFam; TF314208; -.
DR Reactome; R-GGA-9759218; Cobalamin (Cbl) metabolism.
DR PRO; PR:Q5ZKP2; -.
DR Proteomes; UP000000539; Chromosome 7.
DR Bgee; ENSGALG00000012473; Expressed in liver and 13 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0009235; P:cobalamin metabolic process; ISS:UniProtKB.
DR InterPro; IPR019362; MMADHC.
DR PANTHER; PTHR13192; PTHR13192; 1.
DR Pfam; PF10229; MMADHC; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Mitochondrion; Reference proteome; Transit peptide.
FT TRANSIT 1..92
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 93..296
FT /note="Cobalamin trafficking protein CblD"
FT /id="PRO_0000019537"
SQ SEQUENCE 296 AA; 33131 MW; F2669248D96CFADC CRC64;
MANVLCNRAR LVTYLPGFYS LVKRVVNPKA FSTAGSSGSD EPHVAATPPD LCPRTVWPDE
VMGPFGPQDQ RFQLPGNIGF DCHLNGTAAQ RKSQASKSLP DILAEPSPNE RHEFVMAQYI
NEFQGSDVPQ KQQVNNAETY FENAKVECAV QACPELLRKD FESMFPEVNA NHLTVLTVTQ
KTKNDMTVWS QEVEDEREML LENFINGAKE ICYAICSEGY WADFIDPSSG LAFFGPYTNN
TLFETDERYR HFGFSVDDLG CCKVIRHNIW GTHVVVGSIF TNAEPDSPIM RKLSGN
