ID   MMAD_RAT                Reviewed;         296 AA.
AC   Q6AYQ6;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Cobalamin trafficking protein CblD;
DE   AltName: Full=CblD {ECO:0000250|UniProtKB:Q9H3L0};
DE   AltName: Full=Methylmalonic aciduria and homocystinuria type D homolog, mitochondrial;
DE   Flags: Precursor;
GN   Name=Mmadhc;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Involved in cobalamin metabolism and trafficking. Plays a
CC       role in regulating the biosynthesis and the proportion of two
CC       coenzymes, methylcob(III)alamin (MeCbl) and 5'-deoxyadenosylcobalamin
CC       (AdoCbl). Promotes oxidation of cob(II)alamin bound to MMACHC. The
CC       processing of cobalamin in the cytosol occurs in a multiprotein complex
CC       composed of at least MMACHC, MMADHC, MTRR (methionine synthase
CC       reductase) and MTR (methionine synthase) which may contribute to
CC       shuttle safely and efficiently cobalamin towards MTR in order to
CC       produce methionine. {ECO:0000250|UniProtKB:Q9H3L0}.
CC   -!- SUBUNIT: Heterodimer with MMACHC. Forms a multiprotein complex with
CC       MMACHC, MTR and MTRR. {ECO:0000250|UniProtKB:Q9H3L0}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H3L0}.
CC       Mitochondrion {ECO:0000250|UniProtKB:Q9H3L0}.
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DR   EMBL; BC078953; AAH78953.1; -; mRNA.
DR   RefSeq; NP_001004280.1; NM_001004280.1.
DR   AlphaFoldDB; Q6AYQ6; -.
DR   SMR; Q6AYQ6; -.
DR   STRING; 10116.ENSRNOP00000058814; -.
DR   PaxDb; Q6AYQ6; -.
DR   GeneID; 362134; -.
DR   KEGG; rno:362134; -.
DR   UCSC; RGD:1303272; rat.
DR   CTD; 27249; -.
DR   RGD; 1303272; Mmadhc.
DR   VEuPathDB; HostDB:ENSRNOG00000004740; -.
DR   eggNOG; KOG3994; Eukaryota.
DR   HOGENOM; CLU_066240_0_0_1; -.
DR   InParanoid; Q6AYQ6; -.
DR   OMA; IWPDETM; -.
DR   OrthoDB; 1363001at2759; -.
DR   PhylomeDB; Q6AYQ6; -.
DR   TreeFam; TF314208; -.
DR   Reactome; R-RNO-9759218; Cobalamin (Cbl) metabolism.
DR   PRO; PR:Q6AYQ6; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000004740; Expressed in quadriceps femoris and 20 other tissues.
DR   ExpressionAtlas; Q6AYQ6; baseline and differential.
DR   Genevisible; Q6AYQ6; RN.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; ISO:RGD.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0009235; P:cobalamin metabolic process; ISS:UniProtKB.
DR   InterPro; IPR019362; MMADHC.
DR   PANTHER; PTHR13192; PTHR13192; 1.
DR   Pfam; PF10229; MMADHC; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..38
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           39..296
FT                   /note="Cobalamin trafficking protein CblD"
FT                   /id="PRO_0000019536"
FT   MOD_RES         203
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H3L0"
SQ   SEQUENCE   296 AA;  33052 MW;  18908A12413E842C CRC64;
     MAHVLCNRAR LVSYLPGFCS LVKRVINPRA FSTAGSSGSD ESHVATAPPD ICSRTVWPDE
     TMGPFGPQDQ RFQLPGNIGF DCHLNGTASQ KKSQAHKTLP DVLAEPLSTE RHEFVMAQYV
     NEFQDSNAPV EQEISSAETY FESARVECAI QTCPELLRRD FESLFPEVAN SKLMILTVTQ
     KTEHDMTVWS EEVEVEREAL LEKFINGAKE ICYALRAEGY WADFIDPSSG LAFFGPYTNN
     TLFETDERYR HLGFSVDDLG CCKVIRHGLW GTHVVVGSIF TNATADSHIM RKLSGD