MMDC_PROMO
ID MMDC_PROMO Reviewed; 134 AA.
AC O54030;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Methylmalonyl-CoA decarboxylase subunit gamma {ECO:0000305};
DE EC=7.2.4.3 {ECO:0000269|PubMed:9428714};
GN Name=mmdC {ECO:0000303|PubMed:9428714};
OS Propionigenium modestum.
OC Bacteria; Fusobacteria; Fusobacteriales; Fusobacteriaceae; Propionigenium.
OX NCBI_TaxID=2333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CATALYTIC ACTIVITY, SUBUNIT,
RP AND SUBCELLULAR LOCATION.
RC STRAIN=DSM 2376 / Gra Succ2;
RX PubMed=9428714; DOI=10.1111/j.1432-1033.1997.0590a.x;
RA Bott M., Pfister K., Burda P., Kalbermatter O., Woehlke G., Dimroth P.;
RT "Methylmalonyl-CoA decarboxylase from Propionigenium modestum--cloning and
RT sequencing of the structural genes and purification of the enzyme
RT complex.";
RL Eur. J. Biochem. 250:590-599(1997).
CC -!- FUNCTION: Biotin-containing subunit of the sodium ion pump
CC methylmalonyl-CoA decarboxylase, which converts the chemical energy of
CC a decarboxylation reaction into an electrochemical gradient of Na(+)
CC ions across the cytoplasmic membrane, thereby creating a sodium ion
CC motive force that is used for ATP synthesis.
CC {ECO:0000269|PubMed:9428714}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in) = CO2 +
CC Na(+)(out) + propanoyl-CoA; Xref=Rhea:RHEA:21396, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:29101, ChEBI:CHEBI:57327,
CC ChEBI:CHEBI:57392; EC=7.2.4.3; Evidence={ECO:0000269|PubMed:9428714};
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU01066};
CC -!- SUBUNIT: The methylmalonyl-CoA decarboxylase is composed of four
CC subunits: the carboxyltransferase alpha subunit (MmdA), the tunnel beta
CC subunit (MmdB), the biotin-containing gamma subunit (MmdC) and the
CC delta subunit (MmdD). {ECO:0000269|PubMed:9428714}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9428714}.
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DR EMBL; AJ002015; CAA05139.1; -; Genomic_DNA.
DR PIR; T44984; T44984.
DR SMR; O54030; -.
DR KEGG; ag:CAA05139; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004492; F:methylmalonyl-CoA decarboxylase activity; IEA:RHEA.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR011053; Single_hybrid_motif.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR SUPFAM; SSF51230; SSF51230; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
PE 1: Evidence at protein level;
KW Biotin; Cell membrane; Ion transport; Membrane; Sodium; Sodium transport;
KW Translocase; Transport.
FT CHAIN 1..134
FT /note="Methylmalonyl-CoA decarboxylase subunit gamma"
FT /id="PRO_0000453534"
FT DOMAIN 58..134
FT /note="Biotinyl-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01066"
FT REGION 28..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..51
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 100
FT /note="N6-biotinyllysine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01066"
SQ SEQUENCE 134 AA; 13094 MW; 72CC813187273873 CRC64;
MKNFKVTVNG TEYDVAVEEM GGAAVASAPA ARPAAAPAPA APKPAAAPAP APAPKTTAAG
AGAGANTVTA PMPGTILNVG CHAGDKVSKG DTLVVLEAMK MENEIMAPHD GVVSEVRVQQ
GASVNAGDIL VVLS
