ID   MMDD_PROMO              Reviewed;         137 AA.
AC   O54029;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Methylmalonyl-CoA decarboxylase subunit delta {ECO:0000305};
DE            EC=7.2.4.3 {ECO:0000269|PubMed:9428714};
GN   Name=mmdD {ECO:0000303|PubMed:9428714};
OS   Propionigenium modestum.
OC   Bacteria; Fusobacteria; Fusobacteriales; Fusobacteriaceae; Propionigenium.
OX   NCBI_TaxID=2333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CATALYTIC ACTIVITY, SUBUNIT,
RP   AND SUBCELLULAR LOCATION.
RC   STRAIN=DSM 2376 / Gra Succ2;
RX   PubMed=9428714; DOI=10.1111/j.1432-1033.1997.0590a.x;
RA   Bott M., Pfister K., Burda P., Kalbermatter O., Woehlke G., Dimroth P.;
RT   "Methylmalonyl-CoA decarboxylase from Propionigenium modestum--cloning and
RT   sequencing of the structural genes and purification of the enzyme
RT   complex.";
RL   Eur. J. Biochem. 250:590-599(1997).
CC   -!- FUNCTION: Subunit of the sodium ion pump methylmalonyl-CoA
CC       decarboxylase, which converts the chemical energy of a decarboxylation
CC       reaction into an electrochemical gradient of Na(+) ions across the
CC       cytoplasmic membrane, thereby creating a sodium ion motive force that
CC       is used for ATP synthesis (PubMed:9428714). The delta subunit is
CC       required for catalytic activity as well as for the proper assembly of
CC       the individual subunits to an enzyme complex (By similarity).
CC       {ECO:0000250|UniProtKB:Q56724, ECO:0000269|PubMed:9428714}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-methylmalonyl-CoA + H(+)(out) + Na(+)(in) = CO2 +
CC         Na(+)(out) + propanoyl-CoA; Xref=Rhea:RHEA:21396, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:29101, ChEBI:CHEBI:57327,
CC         ChEBI:CHEBI:57392; EC=7.2.4.3; Evidence={ECO:0000269|PubMed:9428714};
CC   -!- SUBUNIT: The methylmalonyl-CoA decarboxylase is composed of four
CC       subunits: the carboxyltransferase alpha subunit (MmdA), the tunnel beta
CC       subunit (MmdB), the biotin-containing gamma subunit (MmdC) and the
CC       delta subunit (MmdD). {ECO:0000269|PubMed:9428714}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9428714};
CC       Single-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the OadG family. {ECO:0000305}.
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DR   EMBL; AJ002015; CAA05138.1; -; Genomic_DNA.
DR   PIR; T44983; T44983.
DR   SMR; O54029; -.
DR   KEGG; ag:CAA05138; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015451; F:decarboxylation-driven active transmembrane transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0004492; F:methylmalonyl-CoA decarboxylase activity; IEA:RHEA.
DR   GO; GO:0015081; F:sodium ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0036376; P:sodium ion export across plasma membrane; IEA:InterPro.
DR   InterPro; IPR005899; Na_pump_deCOase.
DR   Pfam; PF04277; OAD_gamma; 1.
DR   TIGRFAMs; TIGR01195; oadG_fam; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Ion transport; Membrane; Sodium; Sodium transport;
KW   Translocase; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..137
FT                   /note="Methylmalonyl-CoA decarboxylase subunit delta"
FT                   /id="PRO_0000453538"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   137 AA;  14166 MW;  7613765AE78C96AD CRC64;
     MNITELMELF SNPETIKTLE TGDLMTGIGV TVVLGMGITV VALIFLMYII GGMAAIMAEK
     PKEVKETAAA APKPEAAAAP APAANNDEEL VAVIAAAVAA QLGTSASNLI IRNVTRSLDT
     TPAWGRAGIV DQMATRL