MMGT2_MOUSE
ID MMGT2_MOUSE Reviewed; 123 AA.
AC Q8R3L0;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Membrane magnesium transporter 2 {ECO:0000312|EMBL:ABS87352.1};
GN Name=Mmgt2 {ECO:0000303|PubMed:18057121};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:ABS87352.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AND INDUCTION.
RX PubMed=18057121; DOI=10.1152/ajpcell.00238.2007;
RA Goytain A., Quamme G.A.;
RT "Identification and characterization of a novel family of membrane
RT magnesium transporters, MMgT1 and MMgT2.";
RL Am. J. Physiol. 294:C495-C502(2008).
RN [2] {ECO:0000312|EMBL:BAE20417.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAE20417.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:BAE20417.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3] {ECO:0000312|EMBL:EDL10362.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000312|EMBL:AAH25076.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N {ECO:0000312|EMBL:AAH25076.1};
RC TISSUE=Mammary tumor {ECO:0000312|EMBL:AAH25076.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Mediates Mg(2+) transport. {ECO:0000269|PubMed:18057121}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000269|PubMed:18057121}; Multi-pass membrane protein
CC {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:18057121};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: High expression levels in brain and kidney with
CC lower levels in heart, colon and liver. Very low levels in intestine.
CC In kidney, highest levels in distal convoluted tubule.
CC {ECO:0000269|PubMed:18057121}.
CC -!- INDUCTION: Up-regulated by low extracellular Mg(2+).
CC {ECO:0000269|PubMed:18057121}.
CC -!- SIMILARITY: Belongs to the membrane magnesium transporter (TC 1.A.67)
CC family. {ECO:0000305}.
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DR EMBL; EU069462; ABS87352.1; -; mRNA.
DR EMBL; AK004099; BAE20417.1; -; mRNA.
DR EMBL; AK131977; BAE20917.1; -; mRNA.
DR EMBL; CH466601; EDL10362.1; -; Genomic_DNA.
DR EMBL; CH466601; EDL10364.1; -; Genomic_DNA.
DR EMBL; BC025076; AAH25076.1; -; mRNA.
DR EMBL; BC096583; AAH96583.1; -; mRNA.
DR CCDS; CCDS36179.1; -.
DR RefSeq; NP_778167.1; NM_175002.2.
DR RefSeq; XP_006532933.1; XM_006532870.2.
DR RefSeq; XP_011247211.1; XM_011248909.1.
DR RefSeq; XP_011247212.1; XM_011248910.1.
DR RefSeq; XP_011247213.1; XM_011248911.1.
DR RefSeq; XP_011247214.1; XM_011248912.1.
DR RefSeq; XP_011247215.1; XM_011248913.1.
DR RefSeq; XP_011247216.1; XM_011248914.1.
DR AlphaFoldDB; Q8R3L0; -.
DR SMR; Q8R3L0; -.
DR STRING; 10090.ENSMUSP00000128697; -.
DR TCDB; 1.A.67.1.2; the membrane mg(2+) transporter (mmgt) family.
DR iPTMnet; Q8R3L0; -.
DR PhosphoSitePlus; Q8R3L0; -.
DR MaxQB; Q8R3L0; -.
DR PaxDb; Q8R3L0; -.
DR PeptideAtlas; Q8R3L0; -.
DR PRIDE; Q8R3L0; -.
DR ProteomicsDB; 291473; -.
DR Ensembl; ENSMUST00000129162; ENSMUSP00000128669; ENSMUSG00000048497.
DR Ensembl; ENSMUST00000155759; ENSMUSP00000128697; ENSMUSG00000048497.
DR GeneID; 216829; -.
DR KEGG; mmu:216829; -.
DR UCSC; uc007jjr.1; mouse.
DR CTD; 216829; -.
DR MGI; MGI:2448491; Mmgt2.
DR VEuPathDB; HostDB:ENSMUSG00000048497; -.
DR eggNOG; KOG3918; Eukaryota.
DR GeneTree; ENSGT00510000047104; -.
DR HOGENOM; CLU_122437_1_0_1; -.
DR InParanoid; Q8R3L0; -.
DR OMA; TDQPFEG; -.
DR OrthoDB; 1558871at2759; -.
DR PhylomeDB; Q8R3L0; -.
DR TreeFam; TF323267; -.
DR BioGRID-ORCS; 216829; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Mmgt2; mouse.
DR PRO; PR:Q8R3L0; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8R3L0; protein.
DR Bgee; ENSMUSG00000048497; Expressed in ectoplacental cone and 176 other tissues.
DR ExpressionAtlas; Q8R3L0; baseline and differential.
DR Genevisible; Q8R3L0; MM.
DR GO; GO:0005769; C:early endosome; IDA:UniProtKB.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0072546; C:EMC complex; ISO:MGI.
DR GO; GO:0005794; C:Golgi apparatus; IDA:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; TAS:Reactome.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0015087; F:cobalt ion transmembrane transporter activity; IDA:MGI.
DR GO; GO:0005375; F:copper ion transmembrane transporter activity; IDA:MGI.
DR GO; GO:0022890; F:inorganic cation transmembrane transporter activity; IDA:MGI.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IDA:UniProtKB.
DR GO; GO:0005384; F:manganese ion transmembrane transporter activity; IDA:MGI.
DR GO; GO:0032977; F:membrane insertase activity; ISO:MGI.
DR GO; GO:0015099; F:nickel cation transmembrane transporter activity; IDA:MGI.
DR GO; GO:0006812; P:cation transport; IDA:MGI.
DR GO; GO:0006824; P:cobalt ion transport; IDA:MGI.
DR GO; GO:0006825; P:copper ion transport; IDA:MGI.
DR GO; GO:0015693; P:magnesium ion transport; IDA:UniProtKB.
DR GO; GO:0006828; P:manganese ion transport; IDA:MGI.
DR GO; GO:0015675; P:nickel cation transport; IDA:MGI.
DR GO; GO:0045050; P:protein insertion into ER membrane by stop-transfer membrane-anchor sequence; ISO:MGI.
DR GO; GO:0071816; P:tail-anchored membrane protein insertion into ER membrane; ISO:MGI.
DR InterPro; IPR018937; MMgT.
DR Pfam; PF10270; MMgT; 1.
PE 2: Evidence at transcript level;
KW Endosome; Golgi apparatus; Magnesium; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..123
FT /note="Membrane magnesium transporter 2"
FT /evidence="ECO:0000255"
FT /id="PRO_0000365625"
FT TOPO_DOM 1
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 23..40
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 62..123
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT REGION 102..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 123 AA; 13922 MW; 3FDDB29CA8FB506D CRC64;
MVAWLWKVLM GVGLFALTHA AFSAAQHRSH ARLTEKKYEP LPADIVLQTL LAFALTCYGV
VHTAGDFRDR DATSELKDMT FDTLRNRPSF YVFHRSGYRL FQRPDSTHSS NLSASSSDLP
LKF
