ID   MMGT2_RAT               Reviewed;         124 AA.
AC   Q6P719;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Membrane magnesium transporter 2 {ECO:0000250|UniProtKB:Q8R3L0};
GN   Name=Mmgt2 {ECO:0000250|UniProtKB:Q8R3L0};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:AAH61881.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate {ECO:0000312|EMBL:AAH61881.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Mediates Mg(2+) transport. {ECO:0000250|UniProtKB:Q8R3L0}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q8R3L0}; Multi-pass membrane protein
CC       {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:Q8R3L0};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the membrane magnesium transporter (TC 1.A.67)
CC       family. {ECO:0000305}.
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DR   EMBL; BC061881; AAH61881.1; -; mRNA.
DR   RefSeq; NP_001013989.1; NM_001013967.1.
DR   AlphaFoldDB; Q6P719; -.
DR   SMR; Q6P719; -.
DR   PhosphoSitePlus; Q6P719; -.
DR   GeneID; 303211; -.
DR   KEGG; rno:303211; -.
DR   UCSC; RGD:1311260; rat.
DR   CTD; 216829; -.
DR   RGD; 1311260; Mmgt2.
DR   InParanoid; Q6P719; -.
DR   OrthoDB; 1558871at2759; -.
DR   PhylomeDB; Q6P719; -.
DR   PRO; PR:Q6P719; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005769; C:early endosome; ISS:UniProtKB.
DR   GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0072546; C:EMC complex; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0022890; F:inorganic cation transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; ISS:UniProtKB.
DR   GO; GO:0015693; P:magnesium ion transport; ISS:UniProtKB.
DR   InterPro; IPR018937; MMgT.
DR   Pfam; PF10270; MMgT; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Golgi apparatus; Magnesium; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..124
FT                   /note="Membrane magnesium transporter 2"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000365626"
FT   TOPO_DOM        1
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        23..44
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        66..124
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   124 AA;  13796 MW;  EAF024A5690447B8 CRC64;
     MVAWLWKVLV GVGLSALAHA AFSAAQHRSH TRLAEMKYEP LPTDIVLQTL LAFALTCYGV
     VHTAGDFRDR DATSELKNVT FDTLRNRPSF YVFQHSGSSL LQPSDTTRSS NLNVPSSDDI
     RLKF