MMGT_ARATH
ID MMGT_ARATH Reviewed; 104 AA.
AC Q2HIM5; A8MRD2; Q8LD56;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Membrane magnesium transporter;
DE AltName: Full=ER membrane protein complex subunit 5 homolog;
GN OrderedLocusNames=At5g03345; ORFNames=F12E4;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mediates Mg(2+) transport. {ECO:0000250|UniProtKB:Q8K273}.
CC -!- SUBUNIT: Component of the ER membrane protein complex (EMC).
CC {ECO:0000250|UniProtKB:Q8N4V1}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q8N4V1}; Multi-pass membrane protein
CC {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8K273};
CC Multi-pass membrane protein {ECO:0000255}. Early endosome membrane
CC {ECO:0000250|UniProtKB:Q8K273}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q2HIM5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q2HIM5-2; Sequence=VSP_042272;
CC -!- SIMILARITY: Belongs to the membrane magnesium transporter (TC 1.A.67)
CC family. {ECO:0000305}.
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DR EMBL; AL162751; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED90588.1; -; Genomic_DNA.
DR EMBL; BT024556; ABD38895.1; -; mRNA.
DR EMBL; AY086191; AAM64270.1; -; mRNA.
DR RefSeq; NP_568115.1; NM_120413.4. [Q2HIM5-1]
DR AlphaFoldDB; Q2HIM5; -.
DR SMR; Q2HIM5; -.
DR BioGRID; 17143; 91.
DR IntAct; Q2HIM5; 91.
DR STRING; 3702.AT5G03345.1; -.
DR PaxDb; Q2HIM5; -.
DR PRIDE; Q2HIM5; -.
DR ProteomicsDB; 238322; -. [Q2HIM5-1]
DR EnsemblPlants; AT5G03345.1; AT5G03345.1; AT5G03345. [Q2HIM5-1]
DR GeneID; 831867; -.
DR Gramene; AT5G03345.1; AT5G03345.1; AT5G03345. [Q2HIM5-1]
DR KEGG; ath:AT5G03345; -.
DR Araport; AT5G03345; -.
DR TAIR; locus:505006578; AT5G03345.
DR eggNOG; ENOG502S1Q8; Eukaryota.
DR HOGENOM; CLU_122437_4_0_1; -.
DR InParanoid; Q2HIM5; -.
DR OMA; YGVMYIA; -.
DR PhylomeDB; Q2HIM5; -.
DR PRO; PR:Q2HIM5; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q2HIM5; baseline and differential.
DR Genevisible; Q2HIM5; AT.
DR GO; GO:0005769; C:early endosome; IBA:GO_Central.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0072546; C:EMC complex; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:TAIR.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0022890; F:inorganic cation transmembrane transporter activity; IBA:GO_Central.
DR InterPro; IPR018937; MMgT.
DR Pfam; PF10270; MMgT; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Endoplasmic reticulum; Endosome; Golgi apparatus;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..104
FT /note="Membrane magnesium transporter"
FT /id="PRO_0000415520"
FT TOPO_DOM 1..2
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 24..40
FT /note="Lumenal"
FT /evidence="ECO:0000305"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 62..104
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT VAR_SEQ 25..26
FT /note="YR -> CI (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_042272"
FT CONFLICT 79
FT /note="F -> S (in Ref. 4; AAM64270)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 104 AA; 11828 MW; 7F06BDF0CF5C88C4 CRC64;
MNLGFLVGVF GVLILSHAAY STIQYRGLLK IMEEEFSRPP INVILELIIG LALCMWAALT
FPGKFLSIHP DSDENRAVFL PDNSDFMIFN HRGRLFPPQI DMKF
