MMLH_CUPPJ
ID MMLH_CUPPJ Reviewed; 428 AA.
AC O51798; Q471R2;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 25-MAY-2022, entry version 125.
DE RecName: Full=Probable 4-methylmuconolactone transporter;
GN Name=mmlH; OrderedLocusNames=Reut_A1504;
OS Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Cupriavidus necator
OS (strain JMP 134)).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=264198;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9461415; DOI=10.1016/s0378-1119(97)00565-9;
RA Erb R.W., Timmis K.N., Pieper D.H.;
RT "Characterization of a gene cluster from Ralstonia eutropha JMP134 encoding
RT metabolism of 4-methylmuconolactone.";
RL Gene 206:53-62(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JMP134 / LMG 1197;
RX PubMed=20339589; DOI=10.1371/journal.pone.0009729;
RA Lykidis A., Perez-Pantoja D., Ledger T., Mavromatis K., Anderson I.J.,
RA Ivanova N.N., Hooper S.D., Lapidus A., Lucas S., Gonzalez B.,
RA Kyrpides N.C.;
RT "The complete multipartite genome sequence of Cupriavidus necator JMP134, a
RT versatile pollutant degrader.";
RL PLoS ONE 5:E9729-E9729(2010).
CC -!- FUNCTION: Probable uptake of 4-methylmuconolactone.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; X99639; CAA67957.1; -; Genomic_DNA.
DR EMBL; CP000090; AAZ60871.1; -; Genomic_DNA.
DR RefSeq; WP_011297670.1; NC_007347.1.
DR AlphaFoldDB; O51798; -.
DR SMR; O51798; -.
DR STRING; 264198.Reut_A1504; -.
DR TCDB; 2.A.1.15.9; the major facilitator superfamily (mfs).
DR EnsemblBacteria; AAZ60871; AAZ60871; Reut_A1504.
DR KEGG; reu:Reut_A1504; -.
DR eggNOG; COG2814; Bacteria.
DR HOGENOM; CLU_001265_46_6_4; -.
DR OMA; FWACYSG; -.
DR OrthoDB; 1121832at2; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..428
FT /note="Probable 4-methylmuconolactone transporter"
FT /id="PRO_0000050309"
FT TOPO_DOM 1..26
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..50
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..80
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 102..110
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 132..145
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 168..188
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 189..227
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 249..252
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 274..287
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..314
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 336..356
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..371
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 372..377
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 378..398
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 399..428
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 428 AA; 45804 MW; 7CC9096F6F7BE230 CRC64;
MFAWYKAGSP QQKKTFWACY SGWALDSFDM QMFSFLLPAL TLTWGLTKAE VGVLGTVALV
VTAIGGWGAG ILSDRYGRAR ILVLAIIWFT LFGVLAGFAQ SYQQLLIART LQGLGFGGEW
AVGAALMAEV IDSRHRGKAI GFVQSGFALG WALAVVVATL LLAWLPKEMA WRVAFWSGII
PALIVLFIRR HVKDSSMFER ARQSRAPRAS LSSVFNRKYA RTLALSSVLV IGLQAGCYAI
LVWLPSLLNQ RQVAAGSMIV TVFIMAFGSF CGFAVTADLS DRIGRRPTLI LLSVCAWIVT
VSYMLLPLNT TLTAILGFLV GFSAIGMFAA LGPFLSELFP TNVRTTCMGF AYNVGKSIGA
GSVVGVGVLS THIGLANAMG TFCLVAYAFA VFGIMLLPET RGIAIENIGE ADAHSPAAPL
AQPASARS
