ARLY_STRGG
ID ARLY_STRGG Reviewed; 475 AA.
AC B1W3B4;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Argininosuccinate lyase {ECO:0000255|HAMAP-Rule:MF_00006};
DE Short=ASAL {ECO:0000255|HAMAP-Rule:MF_00006};
DE EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE AltName: Full=Arginosuccinase {ECO:0000255|HAMAP-Rule:MF_00006};
GN Name=argH {ECO:0000255|HAMAP-Rule:MF_00006}; OrderedLocusNames=SGR_5967;
OS Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC Streptomyces.
OX NCBI_TaxID=455632;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 4626 / NBRC 13350;
RX PubMed=18375553; DOI=10.1128/jb.00204-08;
RA Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA Yamashita A., Hattori M., Horinouchi S.;
RT "Genome sequence of the streptomycin-producing microorganism Streptomyces
RT griseus IFO 13350.";
RL J. Bacteriol. 190:4050-4060(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00006};
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000255|HAMAP-
CC Rule:MF_00006}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
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DR EMBL; AP009493; BAG22796.1; -; Genomic_DNA.
DR RefSeq; WP_003970275.1; NC_010572.1.
DR AlphaFoldDB; B1W3B4; -.
DR SMR; B1W3B4; -.
DR STRING; 455632.SGR_5967; -.
DR EnsemblBacteria; BAG22796; BAG22796; SGR_5967.
DR GeneID; 6209496; -.
DR KEGG; sgr:SGR_5967; -.
DR eggNOG; COG0165; Bacteria.
DR HOGENOM; CLU_027272_2_3_11; -.
DR OMA; KKNPDVF; -.
DR OrthoDB; 751464at2; -.
DR UniPathway; UPA00068; UER00114.
DR Proteomes; UP000001685; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR CDD; cd01359; Argininosuccinate_lyase; 1.
DR Gene3D; 1.10.275.10; -; 1.
DR HAMAP; MF_00006; Arg_succ_lyase; 1.
DR InterPro; IPR029419; Arg_succ_lyase_C.
DR InterPro; IPR009049; Argininosuccinate_lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR PANTHER; PTHR43814; PTHR43814; 1.
DR Pfam; PF14698; ASL_C2; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; SSF48557; 1.
DR TIGRFAMs; TIGR00838; argH; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; Lyase.
FT CHAIN 1..475
FT /note="Argininosuccinate lyase"
FT /id="PRO_1000089119"
SQ SEQUENCE 475 AA; 51038 MW; B0441F4BECCF46D5 CRC64;
MSSNNGDVRL WGARFADGPA EALAKLSASV HFDWRLAPYD IAGSRAHARV LSKAGLLSED
ELTRMLAGLD QLEADVADGS FTGTIADEDV HTALERGLLE RLGADLGGKL RAGRSRNDQI
ATLFRMYLRD HARTIGGLIA DLQSALVGLA EAHADVAMPG RTHLQHAQPV LFAHHVLAHV
QSLSRDAERL RQWDERTAVS PYGSGALAGS SLGLDPQAVA ADLGFERGSV ANSIDGTASR
DFVAEFAFIT AMIGVNLSRI AEEVIIWNTK EFSFVTLHDA FSTGSSIMPQ KKNPDIAELA
RGKSGRLIGN LTGLLATLKA LPLAYNRDLQ EDKEPVFDSC DQLEVLLPAF TGMMATLTVN
RERMEELAPA GFSLATDIAE WLVKQGVPFR VAHEVAGACV KECERAGIEL DQLTDEQFAE
ISEHLTPEVR TVLNVRGALA SRDGRGGTAP SAVAVQLAEV KEDLAAQHAW ATARP
