ID   MMPL1_MYCTU             Reviewed;         958 AA.
AC   P9WJV9; L0T6D0; P95211;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Probable transport protein MmpL1 {ECO:0000305};
GN   Name=mmpL1; OrderedLocusNames=Rv0402c; ORFNames=MTCY04D9.15c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000305}.
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DR   EMBL; AL123456; CCP43133.1; -; Genomic_DNA.
DR   PIR; A70634; A70634.
DR   RefSeq; NP_214916.1; NC_000962.3.
DR   RefSeq; WP_003898435.1; NZ_NVQJ01000002.1.
DR   AlphaFoldDB; P9WJV9; -.
DR   STRING; 83332.Rv0402c; -.
DR   PaxDb; P9WJV9; -.
DR   PRIDE; P9WJV9; -.
DR   DNASU; 886413; -.
DR   GeneID; 886413; -.
DR   KEGG; mtu:Rv0402c; -.
DR   TubercuList; Rv0402c; -.
DR   eggNOG; COG0642; Bacteria.
DR   eggNOG; COG2409; Bacteria.
DR   OMA; THKGDPA; -.
DR   PhylomeDB; P9WJV9; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR004707; MmpL_fam.
DR   Pfam; PF03176; MMPL; 2.
DR   TIGRFAMs; TIGR00833; actII; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..958
FT                   /note="Probable transport protein MmpL1"
FT                   /id="PRO_0000103562"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        192..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        295..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        329..349
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        762..782
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        791..811
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        814..834
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        868..888
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        906..927
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   958 AA;  104838 MW;  74FC0BC8F54C3A14 CRC64;
     MRSQRLAGHL SAAARTIHAL SLPIILFWVA LTIVVNVVAP QLQSVARTHS VALGPHDAPS
     LIAMKRIGKD FQQFDSDTTA MVLLEGQEKL GDEAHRFYDV LVTKLSQDTT HVQHIENFWG
     DPLTAAGSQS ADGKAAYVQL NLTGDQGGSQ ANESVAAVQR IVDSVPPPPG IKAYVTGPGP
     LGADRVVYGD RSLHTITGIS IAVIAIMLFI AYRSLSAALI MLLTVGLELL AVRGIISTFA
     VNDLMGLSTF TVNVLVALTI AASTDYIIFL VGRYQEARAT GQNREAAYYT MFGGTAHVVL
     ASGLTVAGAM YCLGFTRLPY FNTLASPCAI GLVTVMLASL TLAPAIIAVA SRFGLFDPKR
     ATTKRRWRRI GTVVVRWPGP VLAATLLIAL IGLLALPKYQ TNYNERYYIP SAAPSNIGYL
     ASDRHFPQAR MEPEVLMVEA DHDLRNPTDM LILDRIAKTV FHTPGIARVQ SITRPLGAPI
     DHSSIPFQLG MQSTMTIENL QNLKDRVADL STLTDQLQRM IDITQRTQEL TRQLTDATHD
     MNAHTRQMRD NANELRDRIA DFDDFWRPLR SFTYWERHCF DIPICWSMRS LLNSMDNVDK
     LTEDLANLTD DTERMDTTQR QLLAQLDPTI ATMQTVKDLA QTLTSAFSGL VTQMEDMTRN
     ATVMGRTFDA ANNDDSFYLP PEAFQNPDFQ RGLKLFLSPD GTCARFVITH RGDPASAEGI
     SHIDPIMQAA DEAVKGTPLQ AASIYLAGTS STYKDIHEGT LYDVMIAVVA SLCLIFIIML
     GITRSVVASA VIVGTVALSL GSAFGLSVLI WQHILHMPLH WLVLPMAIIV MLAVGSDYNL
     LLIARFQEEI GAGLKTGMIR AMAGTGRVVT IAGLVFAFTM GSMVASDLRV VGQIGTTIMI
     GLLFDTLVVR SYMTPALATL LGRWFWWPRR VDRLARQPQV LGPRRTTALS AERAALLQ