ID   MMPL2_MYCTO             Reviewed;         968 AA.
AC   P9WJV6; L0T5K7; Q11171;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Probable transport protein MmpL2 {ECO:0000250|UniProtKB:P9WJV7};
GN   Name=mmpL2; OrderedLocusNames=MT0528;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000305}.
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DR   EMBL; AE000516; AAK44751.1; -; Genomic_DNA.
DR   PIR; F70746; F70746.
DR   RefSeq; WP_003898489.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WJV6; -.
DR   EnsemblBacteria; AAK44751; AAK44751; MT0528.
DR   KEGG; mtc:MT0528; -.
DR   PATRIC; fig|83331.31.peg.560; -.
DR   HOGENOM; CLU_005108_3_2_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR004707; MmpL_fam.
DR   Pfam; PF03176; MMPL; 2.
DR   TIGRFAMs; TIGR00833; actII; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..968
FT                   /note="Probable transport protein MmpL2"
FT                   /id="PRO_0000427763"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        245..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        297..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        328..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        763..783
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        787..807
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        815..835
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        866..886
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        890..910
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   968 AA;  106125 MW;  3876125696B22910 CRC64;
     MSERHAALTS LPPILPRLIR RFAVVIVLLW LGFTAFVNLA VPQLEVVGKA HSVSMSPSDA
     ASIQAIKRVG QVFGEFDSDN AVTIVLEGDQ PLGGDAHRFY SDLMRKLSAD TRHVAHIQDF
     WGDPLTAAGS QSADDRAAYV VVYLVGNNET EAYDSVHAVR HMVDTTPPPH GVKAYVTGPA
     ALNADQAEAG DKSIAKVTAI TSMVIAAMLL VIYRSVITAV LVLIMVGIDL GAIRGFIALL
     ADHNIFSLST FATNLLVLMA IAASTDYAIF MLGRYHESRY AGEDRETAFY TMFHGTAHVI
     LGSGLTIAGA MYCLSFARLP YFETLGAPIA IGMLVAVLAA LTLGPAVLTV GSFFKLFDPK
     RRMNTRRWRR VGTAIVRWPG PVLAATCLVA SIGLLALPSY RTTYDLRKFM PASMPSNVGD
     AAAGRHFSRA RLNPEVLLIE TDHDMRNPVD MLVLDKVAKN IYHSPGIEQV KAITRPLGTT
     IKHTSIPFII SMQGVNSSEQ MEFMKDRIDD ILVQVAAMNT SIETMHRMYA LMGEVIDNTV
     DMDHLTHDMS DITATLRDHL ADFEDFFRPI RSYFYWEKHC FDVPLCWSIR SIFDMFDSVD
     QLSEKLEYLV KDMDILITLL PQMRAQMPPM ISAMTTMRDM MLIWHGTLGA FYKQQARNNK
     DPGAMGRVFD AAQIDDSFYL PQSAFENPDF KRGLKMFLSP DGKAARFVIA LEGDPATPEG
     ISRVEPIKRE AREAIKGTPL QGAAIYLGGT AATFKDIREG ARYDLLIAGV AAISLILIIM
     MIITRSVVAA VVIVGTVVLS MGASFGLSVL VWQDILGIEL YWMVLAMSVI LLLAVGSDYN
     LLLISRLKEE IGAGLNTGII RAMAGTGGVV TAAGMVFAVT MSLFVFSDLR IIGQIGTTIG
     LGLLFDTLVV RSFMTPSIAA LLGRWFWWPL RVRPRPASQM LRPFAPRRLV RALLLPSGQH
     PSATGAHE