ID   MMPL2_MYCTU             Reviewed;         968 AA.
AC   P9WJV7; L0T5K7; Q11171;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 34.
DE   RecName: Full=Probable transport protein MmpL2 {ECO:0000305};
GN   Name=mmpL2; OrderedLocusNames=Rv0507; ORFNames=MTCY20G9.34;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
RN   [3]
RP   INDUCTION.
RC   STRAIN=H37Rv;
RX   PubMed=24737322; DOI=10.1074/jbc.m113.538959;
RA   Radhakrishnan A., Kumar N., Wright C.C., Chou T.H., Tringides M.L.,
RA   Bolla J.R., Lei H.T., Rajashankar K.R., Su C.C., Purdy G.E., Yu E.W.;
RT   "Crystal structure of the transcriptional regulator Rv0678 of Mycobacterium
RT   tuberculosis.";
RL   J. Biol. Chem. 289:16526-16540(2014).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Transcriptionally regulated by MmpR5.
CC       {ECO:0000269|PubMed:24737322}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000305}.
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DR   EMBL; AL123456; CCP43244.1; -; Genomic_DNA.
DR   PIR; F70746; F70746.
DR   RefSeq; NP_215021.1; NC_000962.3.
DR   RefSeq; WP_003911183.1; NZ_NVQJ01000002.1.
DR   AlphaFoldDB; P9WJV7; -.
DR   STRING; 83332.Rv0507; -.
DR   PaxDb; P9WJV7; -.
DR   DNASU; 887248; -.
DR   GeneID; 887248; -.
DR   KEGG; mtu:Rv0507; -.
DR   PATRIC; fig|83332.111.peg.559; -.
DR   TubercuList; Rv0507; -.
DR   eggNOG; COG1033; Bacteria.
DR   eggNOG; COG2409; Bacteria.
DR   OMA; PLYGFVF; -.
DR   PhylomeDB; P9WJV7; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0051701; P:biological process involved in interaction with host; IMP:MTBBASE.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR004707; MmpL_fam.
DR   Pfam; PF03176; MMPL; 2.
DR   TIGRFAMs; TIGR00833; actII; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..968
FT                   /note="Probable transport protein MmpL2"
FT                   /id="PRO_0000103563"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        245..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        297..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        328..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        763..783
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        787..807
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        815..835
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        866..886
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        890..910
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   968 AA;  106202 MW;  B68AE9B78164EDC0 CRC64;
     MSERHAALTS LPPILPRLIR RFAVVIVLLW LGFTAFVNLA VPQLEVVGKA HSVSMSPSDA
     ASIQAIKRVG QVFGEFDSDN AVTIVLEGDQ PLGGDAHRFY SDLMRKLSAD TRHVAHIQDF
     WGDPLTAAGS QSADDRAAYV VVYLVGNNET EAYDSVHAVR HMVDTTPPPH GVKAYVTGPA
     ALNADQAEAG DKSIAKVTAI TSMVIAAMLL VIYRSVITAV LVLIMVGIDL GAIRGFIALL
     ADHNIFSLST FATNLLVLMA IAASTDYAIF MLGRYHESRY AGEDRETAFY TMFHGTAHVI
     LGSGLTIAGA MYCLSFARLP YFETLGAPIA IGMLVAVLAA LTLGPAVLTV GSFFKLFDPK
     RRMNTRRWRR VGTAIVRWPG PVLAATCLVA SIGLLALPSY RTTYDLRKFM PASMPSNVGD
     AAAGRRFSRA RLNPEVLLIE TDHDMRNPVD MLVLDKVAKN IYHSPGIEQV KAITRPLGTT
     IKHTSIPFII SMQGVNSSEQ MEFMKDRIDD ILVQVAAMNT SIETMHRMYA LMGEVIDNTV
     DMDHLTHDMS DITATLRDHL ADFEDFFRPI RSYFYWEKHC FDVPLCWSIR SIFDMFDSVD
     QLSEKLEYLV KDMDILITLL PQMRAQMPPM ISAMTTMRDM MLIWHGTLGA FYKQQERNNK
     DPGAMGRVFD AAQIDDSFYL PQSAFENPDF KRGLKMFLSP DGKAARFVIA LEGDPATPEG
     ISRVEPIKRE AREAIKGTPL QGAAIYLGGT AATFKDIREG ARYDLLIAGV AAISLILIIM
     MIITRSVVAA VVIVGTVVLS MGASFGLSVL VWQDILGIEL YWMVLAMSVI LLLAVGSDYN
     LLLISRLKEE IGAGLNTGII RAMAGTGGVV TAAGMVFAVT MSLFVFSDLR IIGQIGTTIG
     LGLLFDTLVV RSFMTPSIAA LLGRWFWWPL RVRPRPASQM LRPFAPRRLV RALLLPSGQH
     PSATGAHE