ID   MMPL4_MYCLE             Reviewed;         959 AA.
AC   P54881;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=Probable transport protein MmpL4 {ECO:0000305};
GN   Name=mmpL4; OrderedLocusNames=ML2378; ORFNames=u1740v;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Smith D.R., Robison K.;
RL   Submitted (APR-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000305}.
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DR   EMBL; U15183; AAA63006.1; -; Genomic_DNA.
DR   EMBL; AL583925; CAC31894.1; -; Genomic_DNA.
DR   PIR; F87206; F87206.
DR   RefSeq; NP_302541.1; NC_002677.1.
DR   RefSeq; WP_010908861.1; NC_002677.1.
DR   AlphaFoldDB; P54881; -.
DR   STRING; 272631.ML2378; -.
DR   PRIDE; P54881; -.
DR   EnsemblBacteria; CAC31894; CAC31894; CAC31894.
DR   KEGG; mle:ML2378; -.
DR   PATRIC; fig|272631.5.peg.4575; -.
DR   Leproma; ML2378; -.
DR   eggNOG; COG1033; Bacteria.
DR   eggNOG; COG2409; Bacteria.
DR   HOGENOM; CLU_005108_3_2_11; -.
DR   OMA; PLYGFVF; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR004707; MmpL_fam.
DR   Pfam; PF03176; MMPL; 2.
DR   TIGRFAMs; TIGR00833; actII; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..959
FT                   /note="Probable transport protein MmpL4"
FT                   /id="PRO_0000103567"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        381..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        766..786
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        790..810
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        818..838
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        872..892
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        902..922
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   959 AA;  105249 MW;  0ECBEEF6E2D232B1 CRC64;
     MTVKCANDLD THTKPPFVAR MIHRFAVPII LVWLAIAVTV SVFIPSLEDV GQERSVSLSP
     KDAPSYIAMQ KMGQVFNEGN SDSVIMIVLE GDKPLGDDAH RFYDGLIRKL RADKHVQSVQ
     DFWGDPLTAP GAQSNDGKAA YVQLSLAGNQ GELLAQESID AVRKIVVQTP APPGITAWVT
     GASALIADMH HSGDKSMIRI TATSVIVILV TLLLVYRSFI TVILLLFTVG IESAVARGVV
     ALLGHTGLIG LSTFAVNLLT SLAIAAGTDY GIFITGRYQE ARQANENKEA AFYTMYRGTF
     HVILGSGLTI SGATFCLSFA RMPYFQTLGV PCAVGMLIAV AVALTLGPAV LTVGSRFGLF
     EPKRLIKVRG WRRIGTVVVR WPLPILITTC AIAMVGLLAL PGYRTNYKDR AYLPASIPAN
     QGFAAADRHF PQARMKPEIL MIESDHDMRN PADFLILDKL ARGIFRVPGI SRVQAITRPD
     GTAMDHTSIP FQISMQNAGQ VQTMKYQKDR MNDLLRQAEN MAETIASMRR MHQLMALLTE
     NTHHILNDTV EMQKTTSKLR DEIANFDDFW RPIRSYFYWE RHCFNIPICW SFRSIFDALD
     GVDQIDERLN SIVGDIKNMD LLMPQMLEQF PPMIESMESM RTIMLTMHST MSGIFDQMNE
     LSDNANTMGK AFDTAKNDDS FYLPPEVFKN TDFKRAMKSF LSSDGHAARF IILHRGDPAS
     VAGIASINAI RTAAEEALKG TPLEDTKIYL AGTAAVFKDI DEGANWDLVI AGISSLCLIF
     IIMLIITRAF VAAAVIVGTV ALSLGASFGL SVLLWQHILG IELHYLVLAM SVIVLLAVGS
     DYNLLLVSRF KQEIQAGLKT GIIRSMGGTG KVVTNAGLVF AFTMASMVVS DLRVIGQVGT
     TIGLGLLFDT LIVRSFMMPS IAALLGRWFW WPQQGRTRPL LTVAAPVGLP PDRSLVYSD